429 results about "Methyl mandelic acid" patented technology

The invention provides a method for screening stereoselective alpha-hydroxy acid dehydrogenase, comprising the following steps: (1) dissolving a sample to be detected containing alpha-hydroxy acid dehydrogenase in a buffer with pH of 6-9, adding an alpha-hydroxy acid chiral monomer as a substrate, and carrying out conversion reaction in water-bath at 20-50 DEG C; and (2) after the conversion reaction, adding the conversion solution in an FeCl3 developer solution to conduct color development reaction for 5-30 min, when the color development reaction finishes, judging the result according to the color appeared in the reaction solution. The method has no need to carry out derivatization on the substrate which is intend to screen, can rapidly identify the dehydrogenase activity and optical selectivity of the selected microbe by using simple colourimetry, has the advantages of simple screening flow, fast speed, low request for devices, strong versatility and the like, and offers great conveniences to the obtainment of optically pure products by using racemic mandelic acid and related derivatives as substrates to carry out resolution through biological enzymatic method.

The invention relates to a preparation method of a titanium-complex-containing liquid fertilizer, which comprises the following steps: 1) dissolving titanyl sulfate or titanium sulfate in water; 2) adding a ligand A; 3) adding a ligand B; and 4) aging, wherein the ligand A and the ligand B are independently selected from tartaric acid, citric acid, malic acid, mandelic acid and lactic acid, and the ligand A and the ligand B are different; the ligand A, the ligand B and Ti (IV) meet the following relationship: 2 <= (the total mole number of the ligand A and the ligand B): the mole number of Ti (IV) <= 12. The invention also relates to the liquid fertilizer prepared by the method, and a solid fertilizer containing the liquid fertilizer. The titanium-complex-containing liquid fertilizer uses few ligands, has higher stability, and is still clear and transparent when being put for more than one year, and the concentration of titanium ion in a solution is almost unchanged, so the liquid fertilizer is of an excellent functional fertilizer.

A polishing composition includes fumed alumina, alumina other than fumed alumina, colloidal silica, a first organic acid, a second organic acid, an oxidizing agent, and water. When the second organic acid is citric acid, the first organic acid is preferably malic acid, while when the second organic acid is malic acid, the first organic acid is preferably citric acid. When the second organic acid is succinic acid, iminodiacetic acid, itaconic acid, maleic acid, malonic acid, crotonic acid, gluconic acid, glycolic acid, lactic acid, or mandelic acid, the first organic acid is preferably either citric acid or malic acid. The polishing composition can be suitably used for polishing the surface of a substrate for a magnetic disk.

The invention discloses a new green synthesizing process for a ketocoumaran compound. The synthesizing process comprises the following steps: in the absence of a solvent, performing condensation reaction of a mandelic acid compound and hydroquinol under the action of a little amount of acid catalyst to obtain a full condensed intermediate, wherein the acid catalyst is selected from one of 10 to 37 percent concentrated hydrochloric acid, 60 to 98 percent concentrated sulfuric acid, fuming sulfuric acid, 80 to 98 percent phosphoric acid, polyphosphoric acid, p-toluenesulfonic acid, trifloromethanesulfonic acid, benzoic acid, ammonium acetate, ammonium chloride, KF, TiC14, NiCl2, CuSO4, Cu(OAc)2, ZnCl2, AlCl3, Fe(NO3)3, FeCl3 and SnCl2; and performing oxidation reaction of full condensed intermediate under the action of an oxidant to obtain a final product ketocoumaran compound. The synthesizing process of the invention is simple, and has low energy consumption and little environmental pollution.

Methods and compositions for treating produce to control microorganisms are provided. The method treats produce by contacting the surface of the produce with an aqueous solution comprising i) an organic peracid of the formula RC(O)OOH wherein R is methyl, ethyl, n-propyl, or s-propyl; ii) a 2-hydroxy organic acid selected from tartaric acid, citric acid, malic acid, mandelic acid, and lactic acid; and (optionally) iii) an anionic surfactant; wherein the aqueous solution has a pH from 2.5 to 6.0.

Antimicrobial and contraceptive compositions and methods which prevent and/or reduce the risk of transmission of sexually transmitted diseases through sexual activity as well as prevent and/or reduce the risk of pregnancy are provided. The compositions contain (1) a matrix-forming agent, (2) a bio-adhesive agent, (3) a buffering agent, (4) optionally a humectant, (5) optionally a preservative, and (6) water; wherein the composition is suitable for application within the vagina; wherein the compositions form a semisolid matrix on contact with ejaculate (thereby trapping ejaculated microbes and spermatozoa); wherein the composition causes hardening of cervical mucus (thereby decreasing the probability of sperm entry); wherein the composition forms a bio-adhesive layer over vaginal surfaces (thereby preventing or reducing the risk of contact of STD-causing microbes with the vaginal surfaces); wherein the composition maintains an acidic vaginal pH of less than about 5 in the presence of semen ejaculated from the male; and wherein the composition does not significantly impair the natural microbiological balance within the vagina. The antimicrobial and contraceptive compositions may also contain additional antimicrobial and/or contraceptive agents (e.g., nonoxynol-9, octoxynol-9, benzalkonium chloride, phosphorylated hesperidins, sulfonated hesperidins, polystyrene sulfonates, substituted benzenesulfonic acid formaldehyde co-polymers, H2SO4-modified mandelic acids, povidone iodine, itraconazole, ketoconazole, metronidazole, clotrimazole, fluconazole, teraconazole, miconazole, tinidazole, iconazole, chloramphenicol, nystatin, cyclopiroxolamine, and the like).

The invention provides a nitrilase gene coding nitrilase, a recombinant vector containing the gene, a recombinant gene engineering bacteria obtained by converting the recombinant vector and application thereof in preparing recombinant nitrilase. The nitrilase gene can be connected with an expression vector for construction to obtain endoenzyme expression recombinant plasmid containing the gene or secretion expression recombinant plasmid, and then the endoenzyme expression recombinant plasmid containing the gene or the secretion expression recombinant plasmid is respectively and correspondingly converted to a colibacillus bacterial strain to obtain recombinant colibacillus; the recombinant colibacillus contains recombinant nitrilase and can recombine colibacillus into an enzyme resource for biological catalysis and conversion. The recombinant nitrilase serves as the enzyme for conversion, and racemisation mandelonitrile, acrylonitrile, iminodiacetonitrile or 2,2-dimethylcyclopropane carbonitrile and the like serve as a substrate for converting to react and prepare corresponding R-mandelic acid, crylic acid, iminodiacetic acid or chiral 2,2-dimethylcyclopropane formic acid and the like.

The invention discloses a method for preparing methoxyphenylacetic acid by natural anethole; the natural anethole is taken as a raw material and generated into the anisicaldehyde by oxidation reaction, then anisic mandelic acid (salt) is generated by the insertion reaction of carbine; finally the methoxyphenylacetic acid is obtained by reduction. The method has the advantages of reproducible raw material, simple operation and high yield, etc.; furthermore, the method can prepare the methoxyphenylacetic acid which can replace the source of petrochemical industry.

The invention relates to a preparation method of R-(-)-mandelic acid and the steps are that: mandelic acid ethyl ester is taken and added in a reactor, then a ionic liquid, a tris(hydroxymethyl)aminoethane-hydrochloric acid buffer solution and a lipase catalyst are added; each milliliter of the ionic liquid is added with 0.1g to 0.3g of the mandelic acid ethyl ester, the amount of lipase is 2.5 percent to 7.5 percent of the weight of the mandelic acid ethyl ester, the ionic liquid: the buffer solution is equal to 1: 1 to 8 accounted by volume ratio, the pH scope of the buffer solution is 6 to 8.5; then reaction is carried out for 5.0 to 10 hours in a constant temperature water bath shaker, filtration is carried out for enzyme removal and water removal, the solids of the mandelic acid and the mandelic acid ethyl ester are obtained by ethyl acetate extraction and rotation evaporation; then n-hexane is added and the R-(-)-mandelic acid is obtained by filtration. The preparation method of the R-(-)-mandelic acid of the invention has simple technique, mild reaction conditions and small environmental pollution; the ionic liquid is taken as a reaction medium, thereby greatly shortening reaction time, the obtained product has high stereoselectivity, the ee value of the product is 60 percent at most, and the yield can achieve 92 percent.

The invention discloses a preparation method for high-purity esomeprazole sodium. The preparation method comprises the steps of: including and splitting esomeprazole sodium and D-(-)-diethyl tartrate, titanium iso-propylate, triethylamine and L-(+)-mandelic acid in the presence of a proper amount of water, and separating to obtain an inclusion complex; dissolving the inclusion complex with ethyl acetate, washing inclusion complex with sodium carbonate water solution, carrying out ammonia hydroxide eluting on an ethyl acetate layer, slowly regulating the pH value to 6-7 with glacial acetic acid, then extracting with dichloromethane, and concentrating to obtain crude esomeprazole free alkali product; carrying out silica gel adsorption and elution on the crude product to obtain a pure esomeprazole free alkali product; and enabling the pure product and the methanol-ethanol-acetonitrile solution of sodium hydroxide to form salt, and then crystallizing with isopropyl ether to obtain the high-purity esomeprazole sodium. According to the preparation method, the difficulties that when inclusion and splitting are carried out, the titanium complex suspension body are difficult to split and the ammonia complex of titanium is difficult to remove can be solved, the industrialization production can be realized, the industrialized production cost is low, the product purity is high, the yield is high, and no harmful gas is generated.

The invention provides a biological preparation method for (1R, 2S)-2-(3,4-difluorophenyl) cyclopropylamine D-mandelate (I). Specifically, the method disclosed by the invention comprises the following steps: (a) taking a compound of a formula VI as a substrate in a liquid reaction system, and carrying out an asymmetric addition reaction in the presence of coenzymes under catalysis of carbonyl reductase so as to form a compound of a formula V; (b) enabling the compound of the formula V to react with triethyl phosphonoacetate so as to obtain a compound of a formula IV; and (c) performing ammonolysis and Hofmann degradation on the compound of the formula IV and salifying with D-mandelic acid, thereby obtaining the compound of the formula VI. The invention further provides a reaction system which comprises (i) an aqueous solvent; (ii) a substrate which is the compound of the formula IV; (iii) coenzymes; (iv) carbonyl reductase; (v) a cosubstrate; and (vi) enzymes used for coenzymes regeneration. The structural formula is as shown in the specification.

Disclosed is a process for commercial preparation of 3-(methylamino)-1-(2-thienyl)propan-1-ol (hereinafter abbreviated as “MMAA”) of the formula below:

The process is carried out by the diastereomeric salt formation method using optically active mandelic acid or its derivatives, or an optically active tartaric acid derivative as the resolving agent. The product compound, diastereomeric satls, is useful as the intermediate for producing pharmaceuticals, such as duloxetine.

A method for preparing 3-methoxy-4-hydroxy mandelic acid adopts guaiacol and glyoxylic acid as raw materials, and comprises the following steps: slowly adding a 30 wt% sodium hydroxide solution into the glyoxylic acid solution with stirring, allowing the mixed solution to react at a reaction temperature of 0-50 DEG C and a pH value of 1-7 to obtain a sodium glyoxylate solution; adding the guaiacol into water with stirring and under the protection of nitrogen gas, slowly adding the 30 wt% sodium hydroxide solution, allowing the mixed solution to react at a reaction temperature of 0-50 DEG C and a pH value of 11-12 to obtain guaiacol sodium; slowly and dropwisely adding the sodium glyoxylate solution into the guaiacol sodium solution with stirring and under the protection of nitrogen gas, with the mole ratio of the sodium glyoxylate and the guaiacol sodium being 1:1.2-2, allowing the mixed solution to react at a reaction temperature of 0-20 DEG C and a pH value of 11-12, 30-90 min afterthe dropwise addition, stirring the mixed solution for 1-3 hours, stopping the reaction at the reaction temperature for 24-36 hours, then acidifying the reaction solution by a 50 wt% sulfuric acid solution to control the pH value to be 4-5. The yield of the reaction is above 95 wt%.

The invention discloses a method for preparing (Z)-3'-hydroxy radical -3,4,4',5-tetra- methoxyl diphenyl ethylene by the material of renewable natural plant resource. Naturally sourced 3,4,5-tri-methoxybenzaldehyde (a derivative extracted from Chinese gall) is taken as the raw material; and 3,4,5-tri-methoyl mandelic acid is obtained through a dichlorocarbene insertion reaction and is reduced to obtain 3,4,5-tri-methoyl phenylacetic acid. The compound can have a Perkin reaction with naturally sourced isovanillin to construct a cis-form diphenyl ethylene backbone, and the (Z)-3'-hydroxy radical -3,4,4',5-tetra- methoxyl diphenyl ethylene is obtained after a decarboxylic reaction. The method adopts the renewable resource-isovanillin and the 3,4,5-tri-methoxybenzaldehyde rich in China to replace increasingly exhausted petrochemical materials, thereby having a good sustainable development capability and remarkable economic, environmental and ecological benefits.

The invention discloses a preparation method of a poly-a-hydroxy acid modified CdTe quantum dot. The preparation method comprises the following steps: preparing a CdTe quantum dot with a mercaptoethanol modified surface by taking the mercaptoethanol as a ligand and adopting a water-phase method; generating a-hydroxy acid oxygen acid anhydride polymerization by adopting hydroxy contained in the surface of the CdTe quantum dot; and introducing poly-a-hydroxy acid, namely polylactic acid, polyglycolic acid, poly (mandelic acid) and the like, to the surface of the CdTe quantum dot so as to realize the polymer modification on the CdTe quantum dot. The poly-a-hydroxy acid modified CdTe quantum dot has the advantages of good hydrophilicity and stability, excellent fluorescence property, good biocompatibility and the like and can be widely applied to the field of biomedicine as a novel fluorescent nanoprobe.

This invention discloses a method for producing optical pure chiral mandelic acid. Use methyl benzoyl formate or the derivative of phenylglyoxylic acid as the bottom thing, the microorganism's cell of yeasts or mould whitlying etc. as catalyst, alternatively reduces the carbonyl in the bottom thing to the hydroxyl to get the chiral mandelic acid relying mainly on a kind of type (usually as R a type). This invention adopts chemistry-biology combination craft , with low cost, the chiral purity is high, easy to realize production for industrialization, it is easy to popularize and apply.

The invention relates to a method for determining content of silicon and zirconium in silicozirconium alloy, and belongs to the technical field of material chemical analysis. The method comprises the following steps: decomposing a sample with nitric acid and hydrofluoric acid to convert the silicon into fluosilicic acid; adding potassium fluoride to generate potassium fluosilicate precipitation; filtering, washing and adding hot water to decompose the potassium fluosilicate precipitation to release hydrofluoric acid; using bromothymol blue or phenolphthalein as indicator to carry out titration with a sodium hydroxide standard solution until the solution turns to blue or light red as an end point; calculating the content of silicon; dissolving the sample with nitric acid and hydrofluoric acid, carrying out perchloric acid smoking, reacting zirconium with mandelic acid in a hot hydrochloric acid medium to generate an insoluble mandelic acid white precipitation; calcining the precipitation at 850-900 DEG C; weighing in the form of oxide; and conducting conversion to obtain the content of zirconium. The method for determining silicon and zirconium content in silicozirconium alloy has not been reported so far, and the method provided by the invention solves the problem, has the advanategs of simpleness, fastness, high accuracy and good repeatability, and is favorable for popularization and application.

The invention discloses a preparation method for (Z)-3'-hydroxyl-3,4,4',5-tetramethoxyl diphenyl ethylene. A diphenyl ethylene framework structure is built by the Perkin reaction method, and natural aniseed fat-soluble components and propenyl anisole (anethole) are taken as raw materials, and oxidized to obtain anisaldehyde; dichlorocarbene insertion reaction is carried out on the anisaldehyde to obtain p-methoxyl-mandelic acid which is reduced to obtain methoxyl-phenylacetic acid, the methoxyl-phenylacetic acid is brominized to obtain 3-bromo-4-methoxyl-phenylacetic acid. The compound and the natural 3,4,5-trimethoxybenzaldehyde (nutgall extract derivative) carry out Perkin reaction to build a cis-form diphenyl ethylene framework which is further converted and decarboxylated by functional groups to obtain the (Z)-3'-hydroxyl-3,4,4',5-tetramethoxyl diphenyl ethylene. The raw materials of the invention are reproducible natural resources-anethole which are rich in China and 3,4,5-trimethoxybenzaldehyde, and replace non-renewable petrochemical materials which are used by the prior art and become less and less so that the method has the advantages of good sustainable development capability as well as remarkable economic, environmental and ecological benefits.

A polishing composition for a substrate to be used for a memory hard disk, which comprises the following components (a) to (d):(a) water,(b) at least one compound selected from the group consisting of a polyoxyethylene polyoxypropylene alkyl ether and a polyoxyethylene polyoxypropylene copolymer,(c) at least one compound selected from the group consisting of nitric acid, nitrous acid, sulfuric acid, hydrochloric acid, molybdic acid, sulfamic acid, glycine, glyceric acid, mandelic acid, malonic acid, ascorbic acid, glutamic acid, glyoxylic acid, malic acid, glycolic acid, lactic acid, gluconic acid, succinic acid, tartaric acid, maleic acid and citric acid, and their salts, and(d) at least one abrasive selected from the group consisting of aluminum oxide, silicon dioxide, cerium oxide, zirconium oxide, titanium oxide, silicon nitride and silicon carbide.

The invention discloses a preparation method of dimethylmorphinan phosphate used as a cough medicine. The method comprises the following steps: removing L-mandelic acid from (S)-l-(4-methylbenzyl)-1,2,3,4,5,6,7,8-octahydroisoquinoline-L-mandelate to obtain (S)-l-(4-methylbenzyl)-1,2,3,4,5,6,7,8-octahydroisoquinoline, performing methylation by using the (S)-l-(4-methylbenzyl)-1,2,3,4,5,6,7,8-octahydroisoquinoline chiral material as a raw material, and then performing cyclization reaction together with phosphoric acid under the conditions of heating and decompression to obtain (9S,13S,14S)-3,17-dimethylmorphinan monophosphate with three chiral centers, namely dimethylmorphinan phosphate; and desalting, rectifying, crystallizing, salifying, drying, and packaging to obtain the refined dimethylmorphinan phosphate product. The method has the characteristics of simple process, low cost, high yield, high product purity, short production cycle and the like, thereby being a synthetic route suitable for industrial mass production.

The invention discloses a reaction treatment method of heliotropin intermediate 3,4- dioxymethylene mandelic acid. The method comprises the following reaction treatment steps: firstly, adding glyoxylic acid in a reaction kettle, adding 1,3-benzodioxole under stirring action, and cooling the glyoxylic acid and 1,3-benzodioxole mixed liquid with brine ice; adding a catalyst, namely concentrated sulfuric acid; then dripping a water-insoluble inert solvent, namely dichloromethane, into a head tank, carrying sampling detection on a reaction mixture, and stopping reaction when the content of 1,3-benzodioxole in the reaction mixture is not reduced any more; and finally, adding water into the reaction kettle, uniformly stirring, discharging and filtering by suction to obtain the solid material, namely 3,4- dioxymethylene mandelic acid. According to the reaction treatment method, the feeding sequence is regulated in the early stage to improve the mixing effect and increase the reaction speed, and the water-insoluble inert solvent is added to dilute the reaction mixture, so that the stirring effect is not influenced, the reaction time is shortened, and the problem of hard stirring in the late reaction stage can be solved.

The invention discloses a bioactive peptide skin activating, ageing preventing and whitening elite liquid and a preparation method thereof, which relates to the technical field of cosmetic. The elite liquid comprises the following ingredients: polyglutamic acid, betaine, hydroxyethylurea, elegant jessamine extract product, vanilla tahitensis fruit extract product, mandelic acid, acetyl hexapeptide-8, soluble proteoglycan, hydrolyzed collagen, tranexamic acid, sodium hyaluronate, alpha-arbutin, a yeast extract product, glycerin and butylene glycol. The preparation method is characterized in that one ingredient is added for fully stirring until a mixture is completely dissolved, and then the next ingredient is added. The raw materials have the advantages of no toxicity, no side effect, safety and reliability; the elite liquid is the multipurpose product which can be directly smeared or used for immersing a wet wipe, and the elite liquid is capable of improving skin metabolism, conditioning skin microcirculation, conditioning qi and blood of face, increasing moisture degree of skin, recovering elasticity, regenerating and activating skin, and has the efficacy of fining, whitening, preventing ageing and antioxidation.

The invention belongs to the field of organic synthesis, particularly relates to an (R)-3-amino piperidine hydrochloride preparation method, and aims to solve the technical problems about high cost, relatively low yield and difficulty in industrialization in an existing synthesis method. The technical scheme to solve the technical problems by the invention is to provide the (R)-3-amino piperidine hydrochloride preparation method. The preparation method comprises the following steps: a, enabling D-mandelic acid and racemic 3-piperidine amide to react in an organic solvent to generate D-mandelic acid organic salt of (R)-3-piperidine amide; b, regulating the pH of the product prepared in the step a to 10-11 and enabling the product to react with pivaloyl chloride to prepare (R)-N-valeryl-3-piperidine amide; c, enabling the (R)-N-valeryl-3-piperidine amide to react in a sodium hypochlorite solution to prepare the product (R)-N-valeryl-3-amino piperidine; d, enabling the (R)-N-valeryl-3-amino piperidine to react in a mixed solution of hydrochloric acid and alcohol to prepare the (R)-3-amino piperidine hydrochloride. The invention provides the novel method with low cost and high yield for preparing the (R)-3-amino piperidine hydrochloride.