29 results about "Methyl mandelic acid" patented technology

The invention discloses a composition for relieving, repairing and promoting skin regeneration as well as a preparation method and application of the composition. The composition is prepared from the following raw materials in parts by weight: 0.1 to 5 parts of mandelic acid, 0.5 to 10 parts of a cynanchum atratum extract, 1 to 8 parts of a xylitol compound, 0.5 to 15 parts of regenerated silicon, 1 to 10 parts of a starfish regeneration repair factor, 0.3 to 1.5 parts of trimethylolpropane tri (3-mercaptopropionic acid) ester, 0.05 to 0.5 part of calcium chloride, 0.1 to 1 part of an additive, 0.2 to 2 parts of chitosan-polycaprolactone, 0.2 to 1 part of a pH regulator and 5 to 15 parts of a solvent. 0.3 to 0.8 part of an antioxidant and 3 to 10 parts of a humectant; the additive is hyaluronic acid or formylated hyaluronic acid. Through a multi-channel synergistic effect, the effects of relieving, repairing and promoting skin regeneration are improved.

The application belongs to the technical field of pharmaceutical chemistry, and particularly relates to clofazimine-organic acid co-crystals, a preparation method and application thereof. The clofazimine-organic acid co-crystal is one of clofazimine-ferulic acid monohydrate co-crystal, clofazimine-ferulic acid co-crystal, clofazimine-glutaric acid co-crystal, clofazimine-glycolic acid co-crystal (CFZ-GA 1:1), clofazimine-glycolic acid co-crystal (CFZ-GA 1:1.5), clofazimine-salicylic acid co-crystal, clofazimine-L-aspartic acid co-crystal, clofazimine-L-pyroglutamic acid co-crystal, clofazimine-gallic acid co-crystal, clofazimine-succinic acid co-crystal, clofazimine-tartaric acid co-crystal and clofazimine-DL-mandelic acid co-crystal. The clofazimine-organic acid co-crystal provided by the application significantly improves the solubility and fluidity of clofazimine, thereby improving the bioavailability of clofazimine, and has a broad medicinal prospect.

The invention provides a cosmetic composition and a preparation method thereof. In particular, the cosmetic composition comprises: a linear saturated dicarboxylic acid having 4 to 10 carbon atoms; mandelic acid or a derivative thereof; and polyaspartic acid or a derivative thereof. The cosmetic composition according to the technical scheme of the invention contains higher content of straight-chain saturated dicarboxylic acid with 4-10 carbon atoms, and has excellent cutin removal and acne inhibition effects when azelaic acid is used as the straight-chain saturated dicarboxylic acid with 4-10 carbon atoms.

The preparation of high-value-added aromatic carboxylic acids via CO2 carboxylation coupling through activation of the benzyl C-H bond in alcohols / amines is a green and sustainable pathway to achieve CO2 resource utilization and contribute to carbon neutrality. However, this field currently faces challenges such as poor catalyst selectivity, low CO2 activation efficiency, and a narrow substrate applicability range, making it difficult to meet practical application needs. To address this issue, this patent discovers that in a heterogeneous electrocatalytic system, cuprous selenide (V2), rich in selenium vacancies, can be used... Se -Cu 2‑x Using Se as the core catalyst, it can not only efficiently promote the synergistic activation of benzyl C-H bonds and CO2 carboxylation, significantly improving the overall catalytic activity of the reaction, but also achieve precise chemoselective carboxylation control for different types of substrates. Specifically, this V Se -Cu 2‑x Se electrocatalysts can efficiently and selectively activate the benzyl C-H bond in alcohols and subsequently induce CO2 carboxylation, exhibiting excellent chemoselectivity in the conversion of benzyl alcohol to mandelic acid and its derivatives. Simultaneously, they also demonstrate excellent catalytic performance for amines, selectively catalyzing the carboxylation of amine substrates such as benzylamine with CO2 to directionally generate phenylglycine and aromatic amine-derived carboxylates. Crucially, in addition to typical benzyl alcohol and benzylamine, the substrate applicability of this catalytic system can be extended to various alcohols and amine derivatives, realizing the carboxylation transformation from simple model substrates to diverse functional molecules, providing a new approach for the large-scale preparation of high-value-added aromatic carboxylates.

The invention discloses a bio-based nonionic dispersant and a preparation method thereof, and belongs to the field of chemical engineering. According to the preparation method, mandelic acid and fatty alcohol which are biologically sourced are adopted as raw materials, bio-based mandelic acid ester containing a mandelic acid structure is obtained through a simple esterification reaction, then the bio-based mandelic acid ester and ethylene oxide are subjected to a ring-opening polymerization reaction, and the bio-based dispersing agent with a novel structure is obtained. And pigment color paste prepared by using the polycarboxylate superplasticizer as a dispersing agent has the characteristics of small pigment particle size, narrow distribution and good stability, and the polycarboxylate superplasticizer is low in price, easy to obtain, low in potential toxicity and biodegradable.

Methods and compositions suitable for treating acne, disrupting biofilms, and / or killing bacteria contained in biofilms are provided. [Solution] A particular method involves contacting skin requiring such treatment with a composition comprising two α-hydroxy acids and a polyhydroxy acid. Another particular method involves applying a composition comprising a first α-hydroxy acid, a second α-hydroxy acid, and a polyhydroxy acid to a surface having a biofilm. A particular composition is a. Glycolic acid in an amount of approximately 0.1% to 7.5% by weight, b. Approximately 0.1% to 5% by weight of gluconolactone, c. Approximately 0.1% to 5% by weight of mandelic acid, d. Glycol and, e. Salt-resistant thickening polymer, It contains, and the total amount of glycolic acid, gluconolactone, and mandelic acid is less than about 15% by weight of the total composition.

The invention relates to the technical field of oilfield chemistry, in particular to an environment-friendly biological blocking remover for oil extraction and a processing technology of the environment-friendly biological blocking remover. The environment-friendly biological blocking remover is prepared from the following components in percentage by weight: 4 to 6 percent of alkyl glycoside, 4 to 6 percent of sophorolipid, 3 to 5 percent of methylglycine diacetic acid, 5 to 8 percent of rhamnolipid, 6 to 8 percent of compound microorganism fermentation liquor, 5 to 8 percent of lipase, 5 to 8 percent of protease, 6 to 8 percent of polymer degrading enzyme, 2 to 4 percent of citric acid, 2 to 4 percent of mandelic acid, 1 to 2 percent of glycerol, 1 to 2 percent of trehalose and 31 to 57 percent of deionized water. The biological enzyme, the biological surfactant, the organic acid and the chelating agent cooperate to fundamentally disintegrate blockages, meanwhile, the microcapsule technology and the nano-bubble technology are used, the action period is greatly prolonged, blockages of deeper parts can be treated, and the treatment effect is good. And corrosion and damage of strong acid and strong alkali to underground pipe columns, tools and stratum rocks are avoided, and secondary damage caused by plug removal operation is prevented.

The invention relates to the technical field of cosmetics, in particular to a preparation method of a supramolecular oleic acid control enzyme composition and application of the supramolecular oleic acid control enzyme composition in cosmetics. The invention relates to a preparation method of a supramolecular controlled oleic enzyme composition. The preparation method comprises the following steps: preparation of a supramolecular NaDES solvent: carrying out a reaction on mandelic acid, betaine and capryloyl glycine to obtain the supramolecular NaDES solvent; preparation of a supramolecular acid enzyme composition: reacting the papain and bromelain compound with a supramolecular NaDES solvent to obtain the supramolecular acid enzyme composition; mandelic acid, betaine and capryloyl glycine are prepared into a supramolecular deep eutectic solvent and a protease compound, and the protease compound is immobilized in the supramolecular deep eutectic solvent, so that the method has the characteristics of simplicity in operation, good solubility, good stability and the like; the finally obtained supramolecular oleate-controlling enzyme composition can realize the combination of acid, amino acid derivatives and enzyme, and achieves the effects of synergistically removing waste cutin and blocked pores of skin, controlling oil, quickly improving the texture and appearance of skin and promoting metabolism of skin.

The application discloses a preparation method of (2R, 5S)-4-Boc-2, 5-dimethyl piperazine. Trans-2, 5-dimethyl piperazine is used as raw material, reacts with di-tert-butyl dicarbonate to generate N-Boc-2, 5-dimethyl piperazine, then is subjected to splitting by L-(+)-mandelic acid to obtain (2R, 5S)-4-Boc-2, 5-dimethyl piperazine mandelic acid salt, and then is separated to obtain 2R, 5S)-4-Boc-2, 5-dimethyl piperazine. The raw material used in the application is cheap and easy to obtain, the reaction condition is mild, the operation is simple, the total reaction yield is high, and the application is suitable for industrial production.

The invention discloses a chitosan / sodium carboxymethyl cellulose / calcium ion antibacterial composite hydrogel self-supporting membrane as well as a preparation method and application thereof. The composite hydrogel membrane takes nano-hydroxyapatite as a multifunctional calcium source and an adsorption enhancing component, and chitosan and sodium carboxymethyl cellulose are crosslinked through mandelic acid steam to form a dual-network matrix. The hydrogel film prepared by the method has the advantages of large metal ion adsorption capacity, excellent antibacterial property, good mechanical property and the like, and can realize the targets of high-efficiency removal of heavy metal ions in industrial wastewater and low-consumption pollution degradation.

This invention provides a method for producing safinamide and its salts that have high optical purity with reduced enantiomerity. [Solution] A method for producing a salt of safinamide having high optical purity is provided, by contacting a mixture containing safinamide and its enantiomers with an acid selected from the group consisting of L-tartaric acid, L-glutamic acid, and D-mandelic acid in a reaction solvent.

The invention relates to the technical field of high polymer materials, in particular to a one-step sequence-controlled hydroxy acid block copolyester preparation method, which comprises: carrying out amine catalysis on mandelic acid and bromoacetyl bromide in acetonitrile to form ester, cyclizing with sodium bicarbonate in N, N-dimethylformamide, and recrystallizing to obtain PDD; the preparation method comprises the following steps: carrying out Mannich reaction on 2, 4-di-tert-butylphenol to obtain a ligand H3L, complexing the ligand H3L with zirconium alkoxide, and carrying out methyl lactate treatment to obtain [ONOO]-Zr; pDD and epsilon-caprolactone are heated and polymerized in the presence of a [ONOO]-Zr catalyst, benzoic acid is terminated, and precipitation and purification are performed to obtain sequence-controlled block copolyester P (PDD-b-CL). Compared with other sequence-controlled block copolymer synthesis methods, the one-step sequence-controlled hydroxy acid block copolyester preparation method provided by the invention has the advantages of mild reaction conditions and simplicity and convenience in operation.

The invention relates to a composite gel composition with synergistic blackhead removal and barrier repair functions. The composite gel composition comprises the following components: 1-2 parts of mandelic acid; 2-3 parts of tea tree essential oil; and 3-5 parts of carboxymethyl yeast glucan, wherein the substitution degree of the carboxymethyl yeast glucan is 65-70%. The mandelic acid is used for dissolving the blackheads, the tea tree essential oil is used for resisting bacteria and inflammation, the carboxymethyl yeast glucan, the purslane extract and the D-panthenol are used for synergistically promoting barrier repair, a'clearing-anti-inflammatory repair 'closed loop is formed, and the problem that the mandelic acid permeates and dissolves the blackheads is solved; the tea tree essential oil is antibacterial and anti-inflammatory; the carboxymethyl yeast glucan and the purslane extract synergistically resist inflammation, relieve and promote repair.

The invention discloses a preparation method of crocodile skin collagen peptide and application of a composition of the crocodile skin collagen peptide in antisepsis, anti-inflammation and skin repair. The crocodile skin collagen peptide provided by the invention is composed of 17 peptide fragments with the molecular weight of 700-1800 Da. The composition obtained by compounding crocodile skin collagen peptide, mandelic acid, lactobionic acid, asiaticoside and nicotinamide has multiple functions of antisepsis, anti-inflammation, skin repair and the like through multi-target point synergism, and the crocodile skin collagen peptide dominates oxidation resistance and skin repair and delays skin aging; mandelic acid is used for mildly conditioning cutin, effectively dredging pores and inhibiting growth and reproduction of acne-related flora; lactobionic acid promotes epidermis renewal, makes the skin moist and delicate, and reduces fine wrinkles; the asiaticoside is used for relieving, diminishing inflammation and relieving irritation reactions such as skin redness and swelling; nicotinamide can regulate sebum secretion, block melanin migration and brighten the skin color. The composition can effectively deal with acnes and complications, and solves the problems that an existing product is high in irritation, easy to leave marks and the like.

The present disclosure relates to fungicidal combinations and fungicidal compositions. The present disclosure provides a fungicidal combination and a fungicidal composition comprising fluazinam and at least a second fungicide selected from the group consisting of a mandelamide fungicide, a phthalimide fungicide, and a benzamide fungicide. The present disclosure also provides fungicidal combinations and fungicidal compositions for controlling or preventing resistant fungal diseases.

Disclosed herein are topical compositions comprising Centella asiatica (Centella asiatica) extract and mandelic acid, wherein the composition has a pH of less than 5, and methods of using the compositions to reduce cellular senescence in the skin and treat dermatoporosis. The topical composition comprising Centella asiatica extract and mandelic acid is effective in reducing the number of senescent cells in mammalian dermis, reducing the senescence-associated secretory phenotype (SASP), downregulating at least one SASP-related gene, increasing the expression of at least one cell cycle-related gene in dermal fibroblasts, downregulating at least one gene associated with skin inflammation, and increasing fibroblast turnover.

The invention discloses a method for extracting and removing a nitrogen-containing compound in fuel oil by using an acidic natural eutectic solvent. The method comprises the following steps: forming the acidic natural eutectic solvent from L-proline, mandelic acid and water, forming L-proline, ascorbic acid and water, and forming L-proline and glycollic acid / lactic acid; the method comprises the following steps: adding nitrogen-containing fuel oil and an acidic natural eutectic solvent into a reactor according to a certain mass ratio, and stirring at a certain temperature; standing and layering to obtain an upper-layer low-nitrogen oil product phase and a lower-layer nitrogen-rich eutectic solvent phase; and performing back extraction on the lower nitrogen-rich eutectic solvent phase to obtain a nitride-containing organic phase and a eutectic solvent phase, and performing reduced pressure distillation after liquid separation to obtain a nitrogen-containing compound and a regenerated eutectic solvent. The acidic natural eutectic solvent disclosed by the invention is simple in preparation process, easily available in raw materials, low in price, green and non-toxic, capable of efficiently removing alkaline and neutral nitrogen compounds in fuel oil at the same time, and excellent in cycle performance.

This invention relates to the preparation of high-purity levetiracetam (S)-2-(2-oxo-1-pyrrolidine)butyramide. The preparation of the high-purity levetiracetam begins with 2-(2-oxopyrrolidine-1-yl)butyric acid as the starting material. Through esterification and ammonolysis, a racemic levetiracetam is obtained, which is then resolved by R-mandelic acid to yield high-purity levetiracetam with a chiral content of over 99.9%, a chiral isomer content of less than 0.05%, and no chloride detected. The chiral isomer (R)-2-(2-oxo-1-pyrrolidine)butyramide recovered after resolution can be racemed and further resolved by R-mandelic acid for the preparation of levetiracetam, achieving a total yield of over 90%. The recovered R-mandelic acid can be reused repeatedly, significantly reducing the consumption of resolving agent. This reaction has a short procedure, is easy to operate, and has a stable yield, which significantly reduces the cost of preparing levetiracetam. In addition, it has a very high chiral content, making it suitable for large-scale industrial production.

The present application belongs to the technical field of analytical chemistry, and particularly relates to a method for determining the content of hafnium in hafnium carbide. The method comprises the steps of sample weighing, high-temperature melting, dissolution and leaching, primary precipitation separation, precipitation dissolution, secondary precipitation separation and constant weight calculation, and uses mandelic acid as a secondary precipitant and a mixture of alkali salt and boric acid as a high-temperature flux. The method provided by the present application is simple in equipment, scientific, fast, reasonable and reliable in determination, and effectively fills the gap in the field of chemical composition detection of internal hafnium carbide materials.

This invention discloses a chiral covalent organic framework composite membrane prepared by in-situ growth and its applications. This invention uses [NALC] as a reference. X -TAPB-DVA COF S As a functionalized material, a chiral covalent organic framework composite membrane was prepared by a secondary in-situ growth method using terephthalaldehyde (PAD) as the linker and 1,3,5-tris(4-aminophenyl)benzene (TAPB) as the nucleation site. This chiral covalent organic framework composite membrane can resolve enantiomers of mandelic acid, warfarin, naproxen, and ibuprofen, exhibiting a wide resolution range and stable resolution performance.

The present invention relates to a mandelic acid addition salt of palmitoyl lysylvalyl-lysine and to cosmetic formulations containing said salt. Furthermore, the present invention relates to the use of mandelic acid for preparing a mandelic acid addition salt of palmitoyl lysylvalyl-lysine, which increases the storage stability of palmitoyl lysylvalyl-lysine.

The application discloses a kind of amygdalin / liquorice acid self-assembled hydrogel and its preparation method and application, preparation method includes the following steps: amygdalin solution and liquorice acid are mixed and dispersed uniformly, stationary, obtain amygdalin / liquorice acid self-assembled hydrogel;The concentration of the amygdalin solution is 0.015~0.040g / mL, and the concentration of liquorice acid in amygdalin / liquorice acid self-assembled hydrogel is 0.015~0.040g / mL.Amygdalin / liquorice acid self-assembled hydrogel microstructure presents three-dimensional porous network structure, can be used to prepare drug for reducing or treating inflammatory encephalopathy, neuron damage encephalopathy, blood-brain barrier destruction disease, complement activation disease, the preparation of the application is simple, safe and aimed at complement activation inhibition.

The invention relates to a synthetic method of an azabicyclo [3.2. 1] octyl-2-ene derivative, and belongs to the technical field of organic synthesis. The synthetic method of the azabicyclo [3.2. 1] octyl-2-ene derivative comprises the following steps: S1, in an inert atmosphere and at a low temperature, carrying out an addition reaction on N-Boc-nortropinone as a raw material and an aryl lithium reagent to obtain an intermediate IM1; s2, removing a Boc protecting group under an acidic condition to obtain an intermediate IM2; and S3, salifying the intermediate IM2 and chiral mandelic acid, performing fractional crystallization and alkali dissociation to obtain a target enantiomer with high optical purity, culturing an S-mandelate single crystal of a compound (1S, 5R)-(+)-3-(4-chlorphenyl)-8-azabicyclo [3.2. 1] oct-2-ene, and determining the absolute configuration of the compound through single crystal diffraction. The synthesis method disclosed by the invention has the characteristics of simple reaction operation in each step, mild conditions, high yield, good repeatability and suitability for industrial large-scale production.

The invention belongs to the technical field of cosmetics, and particularly relates to a mandelic acid-containing ternary supramolecular eutectic composition as well as a preparation method and application thereof. The mandelic acid-containing ternary supramolecular eutectic composition is prepared from mandelic acid, succinic acid and dimethyl sulfone in a mass ratio of (1-4): 1: 1. The preparation method comprises the following steps: respectively taking mandelic acid, succinic acid and dimethyl sulfone, carrying out vacuum drying to remove moisture and impurities so as to obtain pretreated raw materials, adding the pretreated raw materials into a ball mill, adding absolute ethyl alcohol accounting for 10-20% of the total mass of the raw materials as a grinding aid solvent, carrying out grinding so as to obtain a mixture, and finally, carrying out drying to remove an ethanol solvent so as to obtain the mandelic acid-succinic acid composite grinding aid. The mandelic acid-containing ternary supramolecular eutectic composition is obtained. According to the ternary supramolecular eutectic prepared by adopting a specific raw material ratio and a specific process, a stable crystal structure is formed through a hydrogen bond network, the stability, the exfoliating effect and the acne removing effect of the ternary supramolecular eutectic in cosmetic application can be remarkably improved, and meanwhile, the irritation to inflammatory skin is lower.

Provided is a cosmetic composition and the preparation method thereof. Specifically, the cosmetic composition comprises: a linear saturated dicarboxylic acid having 4 to 10 carbon atoms; mandelic acid or a derivative thereof; and a polyaspartic acid or a derivative thereof. The cosmetic composition according to the technical solution comprises a higher content of the linear saturated dicarboxylic acid having 4 to 10 carbon atoms, and when azelaic acid is used as the linear saturated dicarboxylic acid having 4 to 10 carbon atoms, this cosmetic composition has excellent exfoliating and acne-inhibiting effects.

Pharmaceutical compositions including R-MDMA salts O-Methyl Mandelate Form A, Nitrate Form A, and Mandelate Form B exhibit properties that are favorable for a pharmaceutical active ingredient. Methods of treating disorders, including neurological disorders, by administration of these compositions are described.

The invention discloses a preparation method and application of bioactive substance composite gel, and belongs to the technical field of analytical chemistry. The preparation method comprises the following steps: taking sodium 4-carboxyl-2-dodecane amido butyrate, glutathione and luminol as raw materials, and preparing at room temperature; the method comprises the following steps: partially or completely breaking gel through specific action of to-be-detected chiral amino acid or S-mandelic acid, polar groups such as sulfydryl (-SH), amino (-NH2) and carboxyl (-COOH) in chiral peptide glutathione molecules and achiral ECL luminescent material luminol; eCL recognition and quantitative analysis of L-histidine and other series of chiral amino acids and S-mandelic acid are successfully realized. The preparation and detection technology of the gel is low in cost, simple and convenient to operate, high in specificity and good in stability, can meet the trace detection requirement, and has a good industrial prospect.

The present invention relates to a complex comprising mandelic acid and carnitine, and a cosmetic composition comprising same. The cosmetic composition of the present invention comprises a deep eutectic solvent complex, thereby having high skin permeability and exfoliation effects under pH conditions that cause low skin irritation, and excellent low-temperature stability.