Dripping pills contg. (R)-3-[(S)-(5-oxyl-2-pyrrolidinyl)carbonyl]- thiazolidine-4-carboxyl, and its prepn. method

A technology of pyrrolidinyl and thiazolidine, which is applied in the field of medicine, can solve the problems of large size, inconvenient, and inconvenient to carry, and achieve the effects of high dissolution rate and dissolution rate, stable quality, and flexible dosage

Active Publication Date: 2006-01-25
SUZHOU SIXTH PHARMA PLANT OF JIANGSU WUZHONG PHARMA GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the commonly used dosage form is oral liquid, which is bulky and inconvenient to carry; granules and powders need to be ingested, and need to be dissolved when taking medicine, which is inconvenient

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0024] A preparation method of a drop pill dosage form containing (R)-3-[(S)-(5-oxo-2-pyrrolidinyl) carbonyl]-thiazolidine-4-carboxyl (pidotimod), which comprises Follow the steps below:

[0025] First take the substrate and heat it to a molten state, then add (R)-3-[(S)-(5-oxo-2-pyrrolidinyl)carbonyl]-thiazolidine containing 15 to 75% water to the molten substrate - 4-carboxy (pidotimod) suspension, stirred evenly, dripped into the cooling liquid under heat preservation conditions to condense into pellets, removed the cooling liquid, and dried to get the drop pill core; the cooling liquid includes simethicone , liquid paraffin, vegetable oil or a mixture thereof.

[0026] When heating, first take the substrate and heat it to a molten state, then add (R)-3-[(S)-(5-oxo-2-pyrrolidinyl)carbonyl]-thiazolidine-4-carboxyl to the molten substrate (pidotimod), heated to make it into a solution, stirred evenly, dripped into the cooling liquid under the condition of heat preservation,...

Embodiment 1

[0028] Pidotimod 10g

[0029] water 10g

[0030] Macrogol 6000 160g

[0031] Tween-80 1.5g

[0032] Proper amount of hypromellose

Embodiment 2

[0034] Pidotimod 10g

[0035] water 2g

[0036] Monostearic acid 200g

[0037] Appropriate amount of polyvinyl alcohol phthalate

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PUM

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Abstract

A dripping pill containing (R)-3-[(S)-(5-oxy-2-pyrrolidine) carboxyl]-thiazolidine-4-carboxyl (Piduomode) is prepared from (R)-3-[(S)-(5-oxy-2-pyrrolidine) carboxyl]-thiazolidine-4-carboxyl (Piduomode) and matrix through proportional mixing, dripping into cooling liquid and drying.

Description

technical field [0001] The invention belongs to the technical field of medicine, in particular to an immunostimulatory regulator (R)-3-[(S)-(5-oxo-2-pyrrolidinyl)carbonyl]-thiazolidine-4-carboxyl (Pidol Moder) drop pills for the treatment of patients with cellular immune dysfunction. Background technique [0002] (R)-3-[(S)-(5-oxo-2-pyrrolidinyl)carbonyl]-thiazolidine-4-carboxyl (pidotimod, pidotimod in English), is a fully synthetic immunostimulatory Modulators, which produce effects by stimulating and modulating cellular immunity. The adult preventive dose is 800mg each time, once a day. (R)-3-[(S)-(5-Oxo-2-pyrrolidinyl)carbonyl]-thiazolidine-4-carboxy (pidotimod) has been on the market in Europe since 1994, basic experiments and clinical results It shows that it is more prominent in improving the anti-infection immune function of the body than previous immune boosters. (R)-3-[(S)-(5-oxo-2-pyrrolidinyl)carbonyl]-thiazolidine-4-carboxy (pidot...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/427A61K9/20A61P37/02
Inventor 刘志祥米靖宇王金陵阎政戈冬眠杨南林
Owner SUZHOU SIXTH PHARMA PLANT OF JIANGSU WUZHONG PHARMA GROUP
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