The invention relates to multi-vitamin effervescent tablet, which comprises, by weight, 0.05-0.1% of vitamin A, 0.01-0.1% of vitamin B1, 0.01-0.1% of vitamin B2, 0.01-0.1% of vitamin B6, 0.0001-0.0005% of vitamin B12, 1.0-2.0% of vitamin C, 0.3-0.6% of vitamin E, 0.1-0.4% of nicotinic acid, 0.05-0.1% of calcium pantothenate, 0.005-0.01% of folic acid, 50-60% of citric acid, 20-30% of sodium carbonate, 10-15% of lactose, 1.0-1.5% of orange flavor, 1-5% of orange fruit powder, 1-3% of sorbitol, 0.5-0.8% of sucralose, 0.01-0.03% of acesulfame potassium, and 0.01-0.03% of sunset yellow pigment. The prepared multi-vitamin effervescent tablet has characteristics of rapid disintegration and stable quality.