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Novel method for preparing a liver benefiting medicine and its preparation

A technology for the preparation of Feiliganning, which is applied in the direction of medical preparations containing active ingredients, pill delivery, antiviral agents, etc., can solve the problems of single dosage form, low drug quality standards, and no quantitative indicators, etc., and achieve the goal of taking and carrying Convenience, good curative effect, guarantee the effect of medication needs

Inactive Publication Date: 2005-01-26
毛友昌
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, the dosage form is single, and the application dosage form is only capsules, and the quality standard of the drug is low, and there is no quantitative index

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1: Preparation of Dangfei Liganning Capsules

[0029] Clean the two herbs separately, remove impurities, and pass the test for later use; crush the two herbs into coarse powder for later use; take milk thistle and break it, remove the oil, use 80% ethanol as a solvent, slowly infiltrate, and collect the Liquid, recover ethanol under reduced pressure, concentrate into a paste, and set aside; take appropriate amount of PEG6000 and heat and melt at 70°C, dissolve the above total flavonoids of milk thistle with Tween-80 and a small amount of absolute ethanol, mix with PEG6000 melt, cool, and solidify , pulverized, and passed through an 80-mesh sieve for subsequent use; 90% ethanol for medicinal use was heated and refluxed for 2 times, the extract was combined, filtered, and the filtrate recovered ethanol for subsequent use; The ethanol extracts after recovering ethanol are combined, concentrated to an appropriate amount, spray-dried, and the dry cream powder is coll...

Embodiment 2

[0030] Example 2: Preparation of Dangfei Liganning Capsules

[0031]Clean the two herbs separately, remove impurities, and pass the inspection for later use; crush the two herbs into coarse powder for later use; take milk thistle and crush them, remove the oil, and use 80% ethanol as a solvent to heat and reflux for three times to extract The liquids were combined, ultrafiltered, the filtrate was decompressed to recover ethanol, concentrated and dried to make a dry cream powder for later use; take an appropriate amount of PEG6000 and heat it at 70°C to melt, add Tween-80 and a small amount of absolute ethanol to dissolve the above dry cream powder, and melt it with PEG6000 Mix, cool, solidify, pulverize, pass through 80 mesh sieve for later use; for medicinal purposes, carry out gradient extraction with 95%, 75%, and 50% ethanol, ultrafilter the extract, combine the filtrates, recover ethanol, concentrate to an appropriate amount, spray dry, and collect The dry paste powder is...

Embodiment 3

[0032] Example 3: Preparation of Dangfei Liganning Tablets

[0033] Clean the two herbs separately, remove impurities, and pass the inspection for later use; crush the two herbs into coarse powder for later use; take milk thistle and crush them, remove the oil, and use 80% ethanol as a solvent to heat and reflux for three times to extract The liquids were combined, ultrafiltered, the filtrate was decompressed to recover ethanol, concentrated and dried to make a dry cream powder for later use; take an appropriate amount of sodium lauryl sulfate and heat and melt at 70 ° C, add the above dry cream powder and mix, cool, solidify, pulverize, pass 80-mesh sieve for later use; as medicine, 95%, 75%, and 50% ethanol are used for gradient extraction, the extract is ultrafiltered, the filtrate is combined, the ethanol is recovered, concentrated to an appropriate amount, spray-dried, and the dry paste powder is collected, and the above-mentioned milk thistle solid Mix the dispersion and...

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PUM

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Abstract

The invention discloses a novel method for preparing a liver benefiting medicine and its preparation, which overcomes the shortcoming of low biological availability of silymarin in the conventional preparation, the active constituents can be fully kept, and the preparation also has the advantages of good curative effect and easiness in carrying.

Description

technical field [0001] The invention relates to the technical field of Chinese patent medicine preparation technology, in particular to the preparation technology of Dangfei Liganning and its preparation. Background technique [0002] Dangfei Liganning Capsules are composed of milk thistle and traditional Chinese medicine. It has the functions of clearing damp heat, benefiting the liver and reducing jaundice. It is used for jaundice caused by steaming due to damp heat, acute icteric hepatitis, infectious hepatitis, chronic Hepatitis and see damp-heat syndrome. It has been clinically used by thousands of hospitals and has definite curative effect. It has been used for a long time without obvious toxic and side effects. It has been included in the seventeenth volume of Chinese medicine prescription preparations of the Ministry of Health of the People's Republic of China. It is a national essential medicine and a Chinese medicine variety that is promoted...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K9/22A61K9/48A61K9/52A61P1/16A61P31/12
Inventor 毛友昌毛小敏
Owner 毛友昌
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