32 results about "5alpha-reductase" patented technology

The invention relates to a plant polyphenol extract product extracted from Osmanthus fragrans, and a preparation method and uses thereof, and concretely discloses an Osmanthus fragrans polyphenol extract product preparation method. The method comprises the following steps: 1, mixing Osmanthus fragrans with an aqueous solution of an extracting agent according to a solid/liquid ratio of 1g/15-60ml, carrying out microwave extraction of the obtained mixture under a pressure of 200-500KPa and a power of 80-200W for 3-20min, and repeating the above extraction process; and 2, mixing obtained filtrates to obtain a filtrate mixture, and drying the filtrate mixture to obtain an Osmanthus fragrans polyphenol extract product. The Osmanthus fragrans polyphenol extract product can be used for preparing antitumor medicines or healthcare products, and can also be used for inhibiting the activities of 5alpha-reductase.

The invention relates to an oil control and acne removal composition and an application thereof. The oil control and acne removal composition comprises, by weight, 2-25 parts of water-soluble polyurethane, 5-25 parts of kaolin, 1-5 parts of titanium dioxide, 3-10 parts of dipropylene glycol, 0.1-1 part of zinc pyrrolidone carboxylate and 1-5 parts of an anti-acne active substance. A polyurethane-containing mud film is produced by adopting the aqueous polyurethane as a film forming component and selecting the dipropylene glycol as a film forming assistant, the kaolin controls oil through externally adsorbing the oil, and octanoylglycine, sarcosine, Cinnamomum zeylanicum bark extract and zinc salt of strong acid of pyrrolidone can inhibit the oil secretion through inhibiting 5alpha-reductase, so the composition can effectively inhibit acne propionibacteria of acne skins and effectively restore acnes on oily skins.

The invention relates to the field of urogenital system and lower urinary tract diseases. The invention provides a new medicinal composition. The composition comprises medicinal effective compositionof the following substances: I) a first compound selected from medicaments for treating bladder hyperactivity such as muscarinic receptor antagonist and medicaments for treating prostate hyperplasia such as 5alpha-reductase inhibitor and alpha-adrenergic receptor antagonist, precursors thereof and pharmacologically acceptable salts thereof, II) a second compound selected from PDE-5 enzyme antagonist, precursor thereof and pharmacologically acceptable salt thereof, and III) a second compound selected from antidiuretic, precursor thereof and pharmacologically acceptable salt thereof, and optional pharmacologically acceptable vector thereof or diluent. The three medicaments can be combined two by two (such as I + II, or I + III, or II + III), or combined together at the same time (such as I +II + III). The invention also provides a group of methods for treating urogenital system and lower urinary tract diseases of mammals comprising people, wherein the methods comprise applying treatmenteffective dose of the composition to the mammals comprising people needing the treatment.

A method of treating Alzheimer's disease, Parkinson's disease, sexual dysfunction or erectile dysfunction in a man by administration of a 5alpha reductase inhibitor together with a testosterone supplement is described. The method is also concerned with the use of the 5alpha reductase inhibiting compound and the testosterone supplement together with another agent useful for treating erectile dysfunction, including PDE V inhibitors; AGE (advanced glycation end-product) breakers; alpha 1 blockers; alpha 1A antagonists; alpha 2 antagonists; dopamine agonists; dopamine D4 agonists; melanocortin agonists; oxytocin agonists; prostaglandin; radical scavengers; rotamase inhibitors; aviptadil; nitroglycerine; and GPCR agonists for treating male sexual dysfunction or erectile dysfunction.

The invention discloses an urtica open-loop lignan glycoside D serving as a 5alpha-reductase inhibitor, a preparation method thereof and use thereof. The urtica open-loop lignan glycoside D is prepared by using the underground part of urtica triangularis as a raw material, extracting the raw material with alcohol, mixing an alcohol extract with hot water to obtain a suspension, extracting the extract with petroleum ether, ethyl acetate and water-saturated n-butyl alcohol, separating the extract from a raffinate water layer with macroporous resin, eluting the extract and separating and purifying the extract by silica gel column chromatography. The urtica open-loop lignan glycoside D can obviously inhibit the generation of DHT and has the potential to be used to prevent and treat prostate diseases like finasteride which is a masculine medicament. The open-loop lignan glycoside raw material is pure natural vegetable roots and safe and readily available. The method is simple and easy to operate and avoids introducing toxic materials. The urtica open-loop lignan glycoside D is low in cost, has a remarkable effect in spite of a vegetable source and has a great significance for the researches on and development of anti-benign prostatic hyperplasia medicaments.

The present invention provides a kind of slow released epristeride preparation as 5alpha-reductase inhibiter for treating benign hyperplasia of prostate. The slow released epristeride preparation consists of epristeride 10-30 wt%, slow releasing supplementary material 30-60 wt%, and other supplementary material for the rest. The slow releasing supplementary material is hydropropyl methyl cellulose, ethyl cellulose, polyacrylate resin and/or polyhydroxy ethylene. The other supplementary material includes pore creating agent, filler, adhesive, lubricant, wetting agent, solvent and/or filming agent. The slow released epristeride preparation can maintain the blood medicine level for 24 hr and high curative effect.

The present invention relates to new medicinal use of Chinese medicine nutmeg and its extract. Specifically, nutmeg and its extract is used in preparing 5alpha-reductase inhibitor and prostatic hyperplasia treating medicine with obvious curative effect, low cost and convenient use.

The invention discloses a traditional Chinese medicine composition capable of inhibiting the activity of 5alpha-reductase and an application of the traditional Chinese medicine composition to hair loss prevention cosmetics. The traditional Chinese medicine composition consists of cuscuta chinensis, herba siegesbeckiae, blackberry lily, semen allii tuberose, radix scrophulariae, scutellaria baicalensis, subprostrate sophora root and artemisia capillaries. Extracts of the traditional Chinese medicine composition can inhibit the activity of the 5alpha-reductase so that the synthesis of androgen of DHT (double hydrogen testosterone) is inhabited, the excellent function of preventing the sebrrheic alopecia is realized, and the traditional Chinese medicine composition can be used for preparing the hair loss prevention cosmetics.

The invention discloses a traditional Chinese medicine enzyme for balancing male 5alpha-reductase and relates to an alopecia prevention agent, in particular to a biological enzyme prevention alopecia agent. The traditional Chinese medicine enzyme is characterized in that a microbial enzyme is added to a traditional Chinese medicine extract in the ratio being 2:8, and the traditional Chinese medicine enzyme is prepared after mixing; the microbial enzyme is prepared from water, brown sugar, poria cocos, evergreen, tea seeds, rice vinegar, hericium erinaceus, seaweed powder and pine juice through fermentation; the traditional Chinese medicine extract is prepared from water extracts of lotus seeds, fresh ginger, hawthorn fruits, malt, red peony roots, twotoothed achyranthes roots, hiraute shiny bugleweed herbs, motherwort herbs, arnebia roots and Chinese angelica through mixing in weight ratio. Traditional Chinese medicines and the enzyme regulate spleen, stomach, liver and renal functions and balance androgen secretion of human bodies, so that 5alpha-reductase is balanced, and the problem of sebrrheic alopecia is solved basically.

A method of safely and specifically treating the combined metabolic disturbances of insulin resistance and visceral adiposity in male subject with visceral adiposity, metabolic syndrome (also known as the ‘insulin resistance syndrome’, and ‘syndrome X’), type II diabetes, or insulin resistance by administering a 5-alpha reductase inhibiting compound of structural formula I, II, III, or IV is disclosed. The method is also concerned with the use of the 5alpha reductase inhibiting compound together with antidiabetic agents, lipid lowering agents, antihypertensive agents, antiobesity agents, testosterone, testosterone precursors, testosterone prodrugs, testosterone analogs, and other androgen receptor agonists for treating visceral adiposity, metabolic syndrome, type II diabetes and insulin resistance in men.

The invention belongs to the technical field of hair growth and particularly relates to a composition and product for preventing and treating alopecia and a preparation method of the product. The composition is prepared from rape pollens, rye pollens and pygeum africanum. In the composition, the rape pollens have an estrogen-like effect, reduce dandruff and prevent alopecia/promote hair growth, and the rye pollens and pygeum africanum can effectively inhibit the activity of 5alpha-reductase and reduce the excessive secretion of androgen. Experimental results show that the provided compositioncontaining specific components in a proportion for preventing and treating alopecia can achieve the effect of preventing and treating alopecia under the synergistic action, and the composition for preventing and treating alopecia has an obvious effect on alopecia prevention/promotion of hair growth and has no irritation to the skin.

The invention relates generally to the use of anti-sense oligonucleotides, small interfering RNA, and ribozymes to modulate expression of the human steroid 5α-reductase gene and thereby modulate levels of dihydrotestosterone (DHT). Elevated levels of DHT are associated with various disorders including, but not limited to, skin diseases, hair loss, hirsuitism, and benign prostatic hyperplasia. The invention specifically relates to formulations of these anti-sense oligonucleotides, small interfering RNA, and ribozymes for administration to treat and prevent disorders

The invention discloses an anti-hair-loss hair-care composition and application thereof, and aims to provide a composition capable of effectively inhibiting the activity of 5alpha-reductase, reducingthe proliferation of malassezia fufur, and promoting the proliferation of dermal papilla cells. The composition is applied to toiletries, has a remarkable improvement effect on seborrheic alopecia, and is prepared from, by weight, 1-6 parts of a spiraea ulmaria extract, 3-9 parts of a guava fruit extract, 2.5-7 parts of a turmeric root extract, 2-5 parts of a magnolia bark extract and 5-10 parts of a tea extract. The invention belongs to the technical field of daily necessities.

The invention discloses a structure of steroid class compound that has 5alpha-reductase to restrain activity that belongs to medicine chemical field. R₁ is hydrogen, alkyl and benzyl of C₁-C₅; R₂ is alkyl of C₁-C₈, alkanoyl of C₁-C₈, one from benzyl, substituted benzyl, benzoyl, and phenylacetyl and substituted benzoyl. It uses androstenedione as raw material, oxidizing open loop to form 5, 17-carbonyl-A-decarbonization-3, 5-cracking-androstane-3-carboxylic acid and taking reaction with oximation to form intermediate that would react with halogenated hydrocarbon or acyl chloride to gain the product. The advantages of the invention are that it uses common raw material, simple technology, has the activity restraining function to 5alpha-reductase.

The invention discloses a hair-care loss-preventing composition and application thereof. The hair-care loss-preventing composition is prepared from the following components in parts by weight: 0.1-10parts of linfa leaves and 0.1-10 parts of walnut. The hair-care loss-preventing composition is obtained through a lot of experiments and researches by an inventor, the linfa leaves and the walnut arecarefully selected, and the optimal proportion of the linfa leaves and the walnut is obtained, so the obtained composition is safe and non-toxic, has the very strong effect of inhibiting the 5Alpha-reductase activity, and is capable of promoting the metabolism of scalp cells, increasing the scalp blood microcirculation, thereby inhibiting the synthesis of special male sex hormone DHT, and effectively treating a alopecia seborrhoeica symptom caused by an androgen source character. Rhizoma anemarrhenae and flos carthami are compounded, and can penetrate into a hair follicle so as to form a screen-type protective film, so the secretion of oil contamination of the hair follicle is controlled, and the loss of the grown hairs is prevented. Especially, the linfa leaves and the walnut are compounded, the hair follicle is conveniently stimulated, the scalp cells are activated, the blood circulation is reinforced, and the regeneration of the hairs is promoted.

The invention discloses a medicine for treating sebrrheic alopecia. The medicine is prepared from the following Chinese herbal medicines in parts by weight: 10 to 15 parts of semen myristicae, 23 to 27 parts of nettle, 10 to 17 parts of lotus plumule, 3 to 7 parts of raspberry fruit, 4 to 6 parts of spica prunellae, 6 to 8 parts of fructus mori albae, 3 to 5 parts of herba cistanches, 3 to 5 parts of semen cuscutae, 3 to 5 parts of corn stigma, 4 to 7 parts of lepidium meyenii walp, 7 to 9 parts of taro, 2 to 4 parts of Chinese teasel root, 6 to 9 parts of tetrapanax papyrifer, 2 to 5 parts of fructus aurantii, 1 to 3 parts of rhizoma alpiniae officinarum, 5 to 7 parts of edible tree fungus, 6 to 8 parts of cicada slough, 4 to 6 parts of whitish honey, 8 to 10 parts of polycarpaea corymbosa and 6 to 8 parts of narrow leaf spicebush. The medicine can be used for effectively inhibiting 5alpha-reductase so that testosterone is prevented from being converted into dihydrotestosterone and the sebrrheic alopecia is further treated.

The invention provides composition containing Saxifragaceae Chrysosplenium delavayi extract. The composition comprises the Saxifragaceae Chrysosplenium delavayi extract, salmonella typhimurium extracellular vesicles and 2-[(4-tert-butylthiazole-2-yl)imido] thiazoline-4-one, wherein the grain size of the salmonella typhimurium extracellular vesicles is in a range of 50-300 nm. By means of mutual compatibility of the components of the composition, the composition can have an activity inhibiting effect on 5alpha-reductase to different degrees, can be used as a 5alpha-reductase inhibitor, and can be applied to prevention and/or treatment of body discomfort such as hair loss, brittleness and easy breaking of hair, alopecia areata, acne, hair color fading and combination of the symptoms caused by 5alpha-reductase or androgen dependent diseases such as androgenic alopecia, benign prostatic hyperplasia and prostatic cancer easily caused by high-level dihydrotestosterone.

A method of treating Alzheimer's disease, Parkinson's disease, sexual dysfunction or erectile dysfunction in a man by administration of a 5alpha reductase inhibitor together with a testosterone supplement is described. The method is also concerned with the use of the 5alpha reductase inhibiting compound and the testosterone supplement together with another agent useful for treating erectile dysfunction, including PDE V inhibitors; AGE (advanced glycation end-product) breakers; alpha 1 blockers; alpha 1A antagonists; alpha 2 antagonists; dopamine agonists; dopamine D4 agonists; melanocortin agonists; oxytocin agonists; prostaglandin; radical scavengers; rotamase inhibitors; aviptadil; nitroglycerine; and GPCR agonists for treating male sexual dysfunction or erectile dysfunction.