Medicinal composition and application thereof

A kind of composition and medicine technology, applied in the pharmaceutical composition and its application field, can solve the problems such as the treatment effect is not ideal enough

Active Publication Date: 2013-01-30
JIANGSU KANION PHARMA CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Prostatic hyperplasia is a group of diseases with multiple etiologies and requires long-term medication. If synthetic drugs such as α1-receptor blockers and 5α-reductase inhibitors that only target a specific target point have certain side effects during long-term use, such as Hypotension, impotence, sexual dysfunction, headache, etc., and the treatment effect is not satisfactory, thus limiting the application of these drugs in the treatment of benign prostatic hyperplasia

Method used

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  • Medicinal composition and application thereof
  • Medicinal composition and application thereof
  • Medicinal composition and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1～31

[0113] Linolenic acid, palmitic acid, N-(2-hydroxyethyl), 9,12,15-octadecatrienamide, glyceryl linolenate, 15 , 16-dihydroxylinoleic acid, ethyl linolenate, glyceryl palmitate, 24-methylenecholesteryl palmitate, 1,3-dipalmitic acid-2-linolenic acid triglyceride, 1,3- Dilinolenic acid-2-palmitic acid triglyceride, 24-methylene cholesteryl linolenate, cycloalkenyl eucalyptol linolenate, pollen alkanol sterol linoleate, 1,3-dipalmitic acid diglyceride, 1-palmitic acid-2-heptadecanoic acid diglyceride, kaempferol, quercetin, isorhamnetin, gossin, kaempferol 7-O-(6'-rhamnosyl) glucoside, N 1 , N 5 , N 10 -Three-(E)-coumaroylpermidine, N 1 , N 5 , N 10-Tris-(Z)-coumaroylperamidine, 1-O-(β-D-glucose)-(2S,3S,4R)-2N-[(2′R)-2′-Hydroxytetradecanoyl Acenoic acid]-octadecene-3,4-diol, putrescine and indole-3-acetic acid are mixed according to the components and contents described in Table 1 to obtain the pharmaceutical composition of the present invention.

[0114] Wherein, the pre...

Embodiment 29

[0194] Test product: Example 29: by mass percentage, the plant extract of fatty acid compounds is 45%, the proportioning of plant extract of flavonoid compounds is 35% and the plant extract of alkaloid compounds is 20%, and fatty acids, flavonoids are combined These three types of compounds of flavonoids and alkaloids obtain the anti-prostatic hyperplasia pharmaceutical composition of the present invention (wherein the active ingredients are about mass percent: 40% of fatty acid compounds, 30% of flavonoids and 10% of alkaloids) .

[0195] Positive control substance:

[0196] For Qianliekang (Pulean Tablets), the maximum clinical dosage for a 60 kg adult is 12 tablets / d.

[0197] Rat dose determination: According to the conversion relationship between human and animal effective doses, the rat dose is calculated as 6 times the clinical dose of a 60 kg adult, that is, 1.2 tablets / kg. Preparation method: Take 36 Qianliekang tablets, use distilled water as solvent, add Tween-80 ...

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Abstract

The invention discloses a medicinal composition, which comprises two or three of a, b and c, wherein a is long-chain fatty acid compounds of a formula I or plant extract containing the same; b is flavonoid compounds of a formula II or plant extract containing the same; and c is the following alkaloid compounds or plant extract containing the same: N1,N5,N10-tri-(E / Z)-coumaroyl spermidine, 1-O-(beta-D-glucose)-(2S, 3S, 4R)-2N-[(2'R)-2'-hydroxytetracosenoicacid]-octadecylene-3,4-diol, putrescine and indol-3-acetic acid. The medicinal composition of the invention can be used for preparing aromatizing enzyme inhibitor, 5alpha reductase inhibitor, alpha1-adrenergic receptor antagonist, cyclooxygenase-2 inhibitor, prostate-specific antigen (PSA) secretion inhibitor, anti-inflammation medicamentor medicament for resisting prostatic hyperplasia, prostatitis or prostatic cancer.

Description

technical field [0001] The invention belongs to the field of pharmaceutical compositions, in particular to a pharmaceutical composition and its application. Background technique [0002] Benign prostatic hyperplasia (BPH) is a common physiological lesion in elderly men. When the lesion causes a series of symptoms such as urinary obstruction, it is called benign prostatic hyperplasia. Autopsy reports of 1075 cases abroad showed that: at the age of 25 to 30, 10% of men could see early benign prostatic hyperplasia lesions under the microscope; as the age increases, the incidence of benign prostatic hyperplasia diagnosed by histology also increases accordingly; By the age of 51 to 60, the incidence rate increases to 75%; by the age of 85, about 90% of men have histological BPH. It can be seen from the above that with the acceleration of population aging in my country, the incidence of benign prostatic hyperplasia caused by old age continues to rise, and benign prostatic hyperpl...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/352A61K31/202A61K31/232A61K31/20A61K31/201A61K31/164A61K31/7032A61K31/405A61K31/23A61K31/575A61K31/132A61K31/165A61P43/00A61P29/00A61P13/08A61P35/00
Inventor 杨义芳李坤杨必成金丽丽
Owner JIANGSU KANION PHARMA CO LTD
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