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Anti-hair-loss Chinese herbal medicine compound for inhibiting activity of 5alpha-reductase, and preparation method of compound

A Chinese herbal medicine, anti-hair loss technology, applied in medical formula, hair care, drug combination, etc., can solve the problems of high irritation and side effects of western medicine ingredients, increase scalp blood microcirculation, low production cost, and inhibit anti-inflammatory effect Effect

Active Publication Date: 2013-12-18
GUANGZHOU TIANWEN JIAOYAN COSMETICS
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Problems solved by technology

However, the ingredients of western medicine are highly irritating and have great side effects, so the development of natural 5α-reductase inhibitors has been paid more and more attention

Method used

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  • Anti-hair-loss Chinese herbal medicine compound for inhibiting activity of 5alpha-reductase, and preparation method of compound
  • Anti-hair-loss Chinese herbal medicine compound for inhibiting activity of 5alpha-reductase, and preparation method of compound
  • Anti-hair-loss Chinese herbal medicine compound for inhibiting activity of 5alpha-reductase, and preparation method of compound

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preparation example Construction

[0031] The preparation method of the anti-hair loss Chinese herbal medicine compound of Examples 9 to 11 in Table 2 that inhibits the activity of 5α-reductase is specifically: extracting saw palmetto extract, bayberry bark extract, arborvitae extract, Angelica sinensis extract, Anemarrhena anemarrhena Extract, Prunella vulgaris extract, Ginger extract, Sophora flavescens extract, Pineapple extract, Schisandra fruit extract, Kaempfera extract are mixed according to the consumption of corresponding embodiment in Table 2, can obtain corresponding anti-hair loss Chinese herbal medicine compound; The preparation steps of each Chinese herbal medicine extract are as follows: pulverize the corresponding Chinese herbal medicine, soak the pulverized Chinese herbal medicine in pure water under normal pressure for 15 days, and the soaking extraction temperature is 35°C; filter the mixed solution obtained after soaking, and filter the obtained filtrate Concentrate at 60°C to obtain the corr...

Embodiment 23

[0043] The preparation steps of each Chinese herbal medicine extract in Example 23 and Example 24 include: pulverizing the corresponding Chinese herbal medicine, soaking the pulverized Chinese herbal medicine in 70% (mass percentage) ethanol under negative pressure for 7 days, and the soaking extraction temperature is 20 °C; filter the mixed solution obtained after soaking, and concentrate the obtained filtrate at 40 °C to obtain the corresponding Chinese herbal medicine extract.

Embodiment 25

[0044] The preparation steps of each Chinese herbal medicine extract in Example 25 and Example 26 are as follows: pulverize the corresponding Chinese herbal medicine, soak the pulverized Chinese herbal medicine in pure water under normal pressure for 15 days, and the soaking extraction temperature is 35° C.; filter and soak to obtain Concentrate the obtained filtrate at 60°C to obtain the corresponding Chinese herbal medicine extract.

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Abstract

The invention discloses an anti-hair-loss Chinese herbal medicine compound for inhibiting activity of 5alpha-reductase, and belongs to a pharmaceutical composition. The anti-hair-loss Chinese herbal medicine compound comprises a serenoa repens extract, a bayberry bark extract, a platycladus orientalis extract, an angelica sinensis extract, a rhizome anemarrhenae extract, a common selfheal fruit-spike extract, a ginger extract, a sophora flavescens extract, a jackfruit extract, a fructus schizandrae extract and a rhizome kaempferiae extract, wherein the percentage weight of all the extracts is 0.1-99% of the total amount of the anti-hair-loss Chinese herbal medicine compound. The anti-hair-loss Chinese herbal medicine compound is used for treating alopecia seborrheica symptom caused due to male androgenetic alopecia.

Description

technical field [0001] The invention relates to a pharmaceutical composition for preventing hair loss, in particular to a Chinese herbal medicine compound for preventing hair loss which inhibits the activity of 5α-reductase; the invention also relates to a preparation method of the Chinese herbal medicine compound for preventing hair loss. Background technique [0002] Seborrheic alopecia (SA), also known as male pattern alopecia (MPA), androgenetic alopecia (AGA), mostly occurs in middle-aged and young men, aged 25 to 40 About 1 / 3 of adult males suffer from hair loss in various degrees. Although the patient had no obvious symptoms, he urgently required treatment because of the impact on the appearance. [0003] Head hair is strictly affected by androgen. The main androgen in men is testosterone, which can be metabolized into dihydrotestosterone (DHT) under the action of 5α-reductase (5α-R). This change is irreversible of. DHT is the main cause of hair loss. It can bind t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9068A61K8/97A61P17/14A61Q5/12A61Q5/02
Inventor 吴培诚欧春凤梁高卫邹宏图刘伟成周磊姚中华
Owner GUANGZHOU TIANWEN JIAOYAN COSMETICS
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