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Medicinal composition and application thereof
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A technology of composition and medicine, which is applied in the field of pharmaceutical composition and its application, and can solve problems such as unsatisfactory therapeutic effect
Active Publication Date: 2010-11-10
JIANGSU KANION PHARMA CO LTD +1
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Prostatic hyperplasia is a group of diseases with multiple etiologies and requires long-term medication. If synthetic drugs such as α1-receptor blockers and 5α-reductase inhibitors that only target a specific target point have certain side effects during long-term use, such as Hypotension, impotence, sexual dysfunction, headache, etc., and the treatment effect is not satisfactory, thus limiting the application of these drugs in the treatment of benign prostatic hyperplasia
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[0192] Test sample: Example 29: The proportion of plant extracts of fatty acid compounds 45%, flavonoids plant extracts 35% and alkaloids plant extracts 20% by mass percentage, combined with fatty acids, flavonoids Compounds and alkaloids, namely the anti-prostatic hyperplasia pharmaceutical composition of the present invention (wherein the active ingredients are about mass percentage: 40% of fatty acid compounds, 30% of flavonoids and 10% of alkaloids) .
[0194] Qianliekang (Pulean Tablets), the maximum clinical dosage of 60 kg adults is 12 tablets / d.
[0195] Determination of rat dose: According to the conversion relationship between the effective doses of humans and animals, the rat dose is calculated as 6 times the clinical dose of 60 kg adults, that is, 1.2 tablets / kg. Preparation method: Take 36 Qianliekang tablets, use distilled water as a solvent, add Tween-80 as a co-solvent, and prepare a suspension of 300ml.
[0196] Chenetone (General...
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Abstract
The invention discloses a medicinal composition, which comprises two or three of a, b and c, wherein a is long-chain fatty acid compounds of a formula I or plant extract containing the same; b is flavonoid compounds of a formula II or plant extract containing the same; and c is the following alkaloid compounds or plant extract containing the same: N1,N5,N10-tri-(E / Z)-coumaroyl spermidine, 1-O-(beta-D-glucose)-(2S, 3S, 4R)-2N-[(2'R)-2'-hydroxytetracosenoicacid]-octadecylene-3,4-diol, putrescine and indol-3-acetic acid. The medicinal composition of the invention can be used for preparing aromatizing enzyme inhibitor, 5alpha reductase inhibitor, alpha1-adrenergicreceptorantagonist, cyclooxygenase-2 inhibitor, prostate-specific antigen (PSA) secretion inhibitor, anti-inflammation medicamentor medicament for resisting prostatic hyperplasia, prostatitis or prostatic cancer.
Description
technical field [0001] The invention belongs to the field of pharmaceutical compositions, in particular to a pharmaceutical composition and its application. Background technique [0002] Benign prostatic hyperplasia (BPH) is a common physiological disease in elderly men. When the disease causes a series of symptoms such as urinary obstruction, it is called benign prostatic hyperplasia. The autopsy reports of 1075 cases abroad show that: at the age of 25 to 30, 10% of men can see early benign prostatic hyperplasia lesions under the microscope; with the increase of age, the incidence of histologically diagnosed prostatic hyperplasia also increases accordingly; To 51 to 60 years old, the incidence rate increased to 75%; to 85 years old, about 90% of men had histological benign prostatic hyperplasia lesions. It can be seen from the above that with the acceleration of the aging of the population in my country, the incidence of benign prostatic hyperplasia caused by aging continu...
Claims
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Application Information
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