Chinese medicinal composition and application thereof

Abstract

The invention discloses a Chinese medicinal composition and application thereof. The Chinese medicinal composition is prepared from Chinese herbal medicaments, namely, rhizoma anemarrhenae and fructus forsythiae. The Chinese medicinal composition has higher action of inhibiting 5alpha-reductase compared with a single Chinese medicinal extract and can be applied to transdermal administration preparations, cosmetics or health-care food to achieve effects of treating diseases such as acne, benign prostatic hyperplasia, alopecia and the like.

Description

technical field

[0001] The invention relates to a composition and its application, in particular to a traditional Chinese medicine composition and its application. Background technique

[0002] Human 5α-reductase is a protease that relies on reduced coenzyme I (NADPH) to catalyze testosterone (T) to dihydrotestosterone (DHT). As a hydrogen donor, NADPH participates in the catalysis of 5α-reductase, and the catalytic reaction reduces NADPH to NADP + , the hydrogen ions are transferred to the α-face with less steric hindrance of the substrate, so that T is converted into DHT to form a more active androgen. If the level of DHT in the human body is too high, it will cause diseases such as acne, benign prostatic hyperplasia and hair loss. To reduce DHT levels, inhibition of 5α-reductase activity is very important.

[0003] Acne is a complex, chronic and universal sebaceous gland dysfunction disease, which generally occurs in adolescence and is closely related to the level of a...