41results about How to "Control proliferation" patented technology

The method relates to a method of modulating quorum sensing in bacteria. Quorum sensing is inhibited using peptide hydrolases. This inhibition is used to prevent biofilm formation or to break down established biofilms and may also be used to downregulate the production of virulence determinants by pathogenic bacteria. The invention also relates to the use of peptide hydrolase inhibitors for the upregulation of quorum sensing in bacteria, resulting in the overproduction of proteins and the use of this system as an expression system.

The invention relates to a probiotic fermented Chinese herbal medicine composition capable of preventing and controlling diabetes. The probiotic fermented Chinese herbal medicine composition capable of preventing and controlling diabetes mainly comprises following components, by mass, 100 parts of a probiotic fermented Chinese herbal medicine freeze-dried composition, 1 to 100 parts of a probiotic exopolysaccharide freeze-dried composition, 1 to 100 parts of a Chinese herbal medicine extract, 1 to 10 part of chitosan oligosaccharide , 1 to 10 parts of fructo-oligosaccharide, 1 to 10 parts of inulin, 1 to 10 parts of soluble dietary fiber, and 1 to 10 parts of insoluble dietary fiber. According to a preparation method, the above components are mixed to be uniform so as to obtain the probiotic fermented Chinese herbal medicine composition. The probiotic fermented Chinese herbal medicine composition is capable of preventing diabetes, and controlling and improving diabetes symptoms via changing intestinal flora, promoting intestinal activity, and improving immunity. Qualitative and quantitative representation of the change of in vivo immune factors can be realized via measuring related immune factor and endotoxin levels.

The invention discloses a medicinal liquor for treating cancer and process for preparation, wherein the main constituents include (by weight ratio) Phellinus igniarius 3-15 parts, ganoderma lucidum 3-20 parts, secretio bufonis 3-20 parts, pallas-pit viper spirit 5-50 parts, and yellow rice wine 3000-5000 parts.

The invention discloses new application of a 2-(4-fluorophenyl)-3-nitro-8-O-ethyl-2-hydro-benzopyran compound, in particular application of the compound serving as phosphatidylinositol-3-kinase (PI3K) inhibitor. The PI3K inhibitor can inhibit PI3K and disturb a PI3K / AKT signal channel, has good treatment effect on multiple tumors, particularly malignant hematological diseases, can effectively control the propagation of tumor cells and induce the apoptosis thereof, and has the effect of inhibiting and treating the tumors; and meanwhile, the PI3K has low toxicity.

The invention relates to the field of traditional Chinese medicine and natural medicine, in particular to an Aquilaria sinensis fruit and an extract thereof. The invention also discloses novel application of the Aquilaria sinensis fruit and the extract to preparation of antitumor drugs.

The invention relates to external medicinal liquor for treating cancer and a preparation method thereof. The preparation method of the external medicinal liquor comprises the following steps of: crushing three pure natural plant medicaments such as aizoon stonecrop herb, radix gynurae segeti and vietnamese sophora root; charging the medicaments and original juice liquor into a high temperature resisting glass bottle; fermenting the mixture; filtering out medicinal liquid; and adding a little musk. All the components of the external medicinal liquor are mutually matched, and have the effects of activating blood and dissolving stasis, freeing channels and dissipating binds, eliminating toxic materials and drawing out poison, dispersing swelling and relieving pain, strengthening body resistance and dispersing tumor together. The external medicinal liquor can control hyperplasia of cancer cells, prevent diffusion transfer of the cancer cells and make the cancer cells collapse, shed and disappear.

The invention relates to the medical technical field of repairing wounds, which can be used for repairing wounds, particularly for healing deep burn wounds. The invention provides mesenchymal stem cell suspension which contains human epidermal growth factor and bovine basophilic fibroblast growth factor. The mesenchymal stem cell provides the sources for human marrows or embryo. When in use, the stem cell suspension is directly injected or smeared on wounds which have been removed necrotic tissues. Animal experiments show that the stem cell suspension can obviously repair deep burn wounds; besides, the new skin does not tend to generate blister or ulceration. The stem cell suspension of the invention is simple in preparation and conveniently for use, obviously repairing the deep burn wounds, thus effectively controlling the hyperplasia of anaphase keloid.

The invention discloses a traditional Chinese medicine capable of benefiting qi, activating blood circulation, softening hardness, dissipating stagnation, realizing detoxification and relieving pain. The traditional Chinese medicine is prepared from raw materials in parts by weight as follows: 2-6 parts of pseudo-ginseng, 1-4 parts of American ginseng, 5-15 parts of spreading hedyotis herb, 5-15 parts of barbed skullcap herb, 5-10 parts of white peony roots, 2-6 parts of Chinese angelica, 5-15 parts of common selfheal fruit-spike, 2-6 parts of Chinese thorowax roots, 2-6 parts of fructus aurantii and 2-6 parts of liquorice roots. The invention further discloses a preparation method of the traditional Chinese medicine. The traditional Chinese medicine has functions of benefiting the qi, activating the blood circulation, softening the hardness, dissipating the stagnation, realizing detoxification and relieving the pain and can control the growth of tumors and obviously improve clinical symptoms of tumor patients, total effective rates are higher than 65% for treatment of lung cancer, liver cancer, esophageal cancer, breast cancer and gastric cancer, besides, the traditional Chinese medicine also has the characteristics of small taking dosage, convenience in taking, storage and carrying, high compliance and the like.

The invention provides a medicine for treating cancer. The medicine is made from lentinus edodes polysaccharide, hericium erinaceus polysaccharides, glutamic acid, aspartic acid, tuckahoe, soybean oligosaccharide and fructo-oligosaccharide. The medicine can control cancer cell hyperplasia and prevent diffusion and metastasis of cancer cells so as to result in withering, falling off and disappearance of the caner cells.

The invention relates to a method of using carbonated water for preserving raw milk. The method is performed in a system and includes the specific steps of (1) carbonation of water by mixing CO2 gas subjected to purification treatment with water subjected to sterile cooling, so that carbonated water saturated solution is obtained; (2) raw milk pretreatment by means of raw milk degasification, centrifugal raw milk purification and pre-pasteurization; and (3) spraying of the carbonated water to raw milk by spraying the carbonated water in the step (1) into the raw milk in the step (2), and uniformly mixing so that the raw milk prepared by the carbonated water preserving method is obtained. By the method of using the carbonated water for preserving the raw milk, the used carbonated water which is liquid is extremely easily mixed with the raw milk and can be well and uniformly mixed with the raw milk, and the addition quantity of the carbonated water can be flexibly adjusted according to different processing products, so that waste caused by escape of the CO2 gas can be avoided. The method is simple and easy to operate, preserving and processing costs are saved, and production efficiency of enterprises is improved. Additionally, the method is not high in requirements on cooling pressurization and spraying equipment and suitable for popularization of large-scale production of the enterprises.

The invention discloses a method for inducing differentiation of sweat gland cells by epidermal stem cells, wherein the method comprises the following steps: 1) separating epidermal stem cells from isolated skin tissues, and subculturing with an epidermal stem cell culture medium; 2) subculturing the epidermal stem cells obtained in the step 1), adding a sweat gland cell induced culture medium, and carrying out induced differentiation; and 3) subculturing and proliferating by the sweat gland cell culture medium. The invention also provides a corresponding culture medium group. In the method, the cell source effectively avoids the ethical controversy. The preparation method is helpful to preparation of the sweat gland cells with homogeneous cell directional differentiation and proliferationconditions.

A polyhydroxy binaphthylaldehyde-fatty acid product used as a novel broad-spectrum antiviral agricultural chemical for agricultural crops, fruit tree, vegetables, flower, forest and medicinal herbs is prepared from polyhydroxy binaphthylaldehyde and fatty acid. Its advantages are high treating and preventing effect and safety, and low dependency.

The present invention provides compositions and methods suitable for delivering RNAi agents against genetic targets in stem cells so as to direct cell growth and differentiation.

A Chinese patent medicine for treating cancer is prepared from 11 Chinese medicinal materials including human placenta, borax , ox gallstone, musk, etc.. It can prevent cancer cells from hyperplasia and transferring, and make them wither and die. Its advantages are high curative effect and no toxic by-effect.

The present invention discloses applications of human SAMD9L gene and a protein product encoded by the human SAMD9L gene, wherein the SAMD9L gene sequence, especially the open reading frame sequence of the protein encoded by the human SAMD9L gene, generates missense mutation, nonsense mutation, frameshift mutation and other gene structure variations with different forms in tumors so as to be adopted as the specific marker gene for liver cancer diagnosis, such that liver cancer diagnosis is accurate and rapid. According to the present invention, the human SAMD9L protein can be applied on tumor patients so as to treat or alleviate related diseases caused by SAMD9L protein deletion, nonfunction or abnormality; and the human SAMD9L gene can be over-expressed in cancer cells through the transgenic technology, or the SAMD9L protein can be supplied through the in vitro supply manner to control cancer cell proliferation and metastasis so as to achieve the tumor treatment purpose.

The present disclosure relates to a method for producing pulp-containing juice, which may produce pulp-containing juice without loss of nutrients while maintaining the flavor and color of a raw material. The method includes squeezing raw material for juice to obtain juice and sterilizing the juice by non-thermal high-pressure processing. Thus, the method may inactivate microorganisms or enzymes, maintain the quality of the juice in a fresh state, and prevent the flavor and nutrients of the raw material from being lost by high-temperature sterilization. In addition, through a quick freezing process, it is possible to prevent the layer separation phenomenon from occurring, prevent the nutrients from being destroyed by temperature changes, and maintain the uniform color of the pulp-containing juice even without using a colorant. A user can conveniently drink the pulp-containing juice produced by this method while feeling the flavor of the fruit thereof without loss of nutrients.

The invention relates to a method for preserving raw milk by introducing nitrogen to the raw milk. The method concretely comprises the following steps: preparing nitrogen by using air, and carrying out purifying treatment on the prepared nitrogen; carrying out centrifuge purifying treatment on the raw milk, and pre-pasteurizing; and introducing nitrogen to discharge oxygen dissolved in the raw cow milk in order to nitrogen filled cow milk. Nitrogen used in the preservation number of the raw milk accounts for 78% of the volume of air, exists in air in a single substance form, is inexhaustible, is a colorless, nontoxic and tasteless inert gas, is highly safe, and can be well and uniformly mixed with the raw milk, and the introduction amount of nitrogen can be flexibly adjusted according to the difference of processing products. The method has the advantages of simplicity, easy operation, preservation and processing cost saving, improvement of the production efficiency of an enterprises, and low requirements on equipment, and is suitable for the large scale production popularization of the enterprise.

The invention relates to a method for enriching vibrio phage and biologically preventing host bacteria. Due to splitting specificity of the phage, the phage of the specific host strains in the specific environment and a certain state cannot be obtained easily. According to the facts that the vibrio strains and the phage of culture zones and sea areas coexist with the environment ecologically and evolutionally, a long-term culture pool of the host bacteria and the phage is built in a specific area, lytic phage of specific pathogenic bacteria hosts in the area can be continuously enriched and separated, the lytic phage can be placed in the area after augmentation, proliferation of pathogenic bacteria of a cultivation water body can be controlled in a short time, concentration of the pathogenic bacteria of the water body can be restrained in a long term, and the effect of ecological defense is achieved. The method utilizes the phage in the cultivation sea water body to prevent diseases caused by the pathogenic bacteria and has the advantages of being efficient, ecological, safe, safe and lasting.

The invention discloses a Chinese medicinal composition and application thereof. The Chinese medicinal composition is prepared from Chinese herbal medicaments, namely, rhizoma anemarrhenae and fructus forsythiae. The Chinese medicinal composition has higher action of inhibiting 5alpha-reductase compared with a single Chinese medicinal extract and can be applied to transdermal administration preparations, cosmetics or health-care food to achieve effects of treating diseases such as acne, benign prostatic hyperplasia, alopecia and the like.

The invention relates to a method of using carbonated water for preserving raw milk. The method is performed in a system and includes the specific steps of (1) carbonation of water by mixing CO2 gas subjected to purification treatment with water subjected to sterile cooling, so that carbonated water saturated solution is obtained; (2) raw milk pretreatment by means of raw milk degasification, centrifugal raw milk purification and pre-pasteurization; and (3) spraying of the carbonated water to raw milk by spraying the carbonated water in the step (1) into the raw milk in the step (2), and uniformly mixing so that the raw milk prepared by the carbonated water preserving method is obtained. By the method of using the carbonated water for preserving the raw milk, the used carbonated water which is liquid is extremely easily mixed with the raw milk and can be well and uniformly mixed with the raw milk, and the addition quantity of the carbonated water can be flexibly adjusted according to different processing products, so that waste caused by escape of the CO2 gas can be avoided. The method is simple and easy to operate, preserving and processing costs are saved, and production efficiency of enterprises is improved. Additionally, the method is not high in requirements on cooling pressurization and spraying equipment and suitable for popularization of large-scale production of the enterprises.

The invention relates to an environment-friendly pomacea canaliculata prevention and control agent and applications thereof. The invention belongs to the field of preventing and controlling foreign invasive species, and discloses an environment-friendly pomacea canaliculata prevention and control agent and applications thereof, wherein the environment-friendly pomacea canaliculata prevention and control agent comprises a routine pomacea canaliculata control agent, an emergency pomacea canaliculata control agent and a pomacea canaliculata oviposition inhibitor. The environment-friendly pomacea canaliculata prevention and control agent comprises a series of formulas of NaCl, KCl, CaCl2, MgCl2, MgSO4 and NaHCO3. In use, three reagents are applied respectively or together by combining the size of a water body according to the population density of the pomacea canaliculata in the water body; the routine pomacea canaliculata control agent is used for low density occurrence situation of pomacea canaliculata; the emergency pomacea canaliculata control agent is used for large population density of pomacea canaliculata, especially the situation of large outburst of the pomacea canaliculata; the pomacea canaliculata oviposition inhibitor is used for controlling the pomacea canaliculata oviposition. The components of the environment-friendly pomacea canaliculata prevention and control agent are common in the environment and are all inorganic substances, so that the environment-friendly pomacea canaliculata prevention and control agent is environmentally friendly and pollution-free. The invention successfully summarizes a set of serial technology for controlling and killing pomacea canaliculata and pomacea canaliculata oviposition according to the class and the damage degree, thus having important significance on guarantee of grain safety and an ecological environment safety.

A Chinese patent medicine for treating cancers is characterized in that the Chinese patent medicine for oral administration is prepared from, by weight, 27-33 parts of human placenta, 27-33 parts of rhizoma paridis, 27-33 parts of pseudobulbus cremastrae seu pleiones, 27-33 parts of sal ammoniac, 27-33 parts of borax, 27-33 parts of anhydrous sodium sulphate, 3-5 parts of calculus bovis, 3-5 parts of musk, 2-4 parts of venenum bufonis, 3-5 parts of cantharides and 13-17 parts of rhizoma coptidis.

The invention discloses a phenyl modified material, a preparation method and an application thereof. The phenyl modified material is prepared according to the following steps: 1) adopting mercaptan containing phenyl as a solute and adopting anhydrous ethanol as a solvent to prepare a mercaptan solution with a mass concentration of 0.8-1.5%, and standing the solution for 12-24 hours at a temperature of 3-8 DEG C, wherein the molecular formula of the mercaptan containing phenyl is C6H6(CH2)nSH, and n is a positive integer; 2) growing a titanium (Ti) transition layer on a surface of a single crystal silicon wafer, and growing a gold layer on the Ti transition layer to obtain a gold-plated silicon wafer; 3) under a dark condition, adding the gold-plated silicon wafer from the step 2) to the prepared mercaptan solution from the step 1), and standing for 12-24 hours to obtain the phenyl modified material. The phenyl modified material of the present invention can inhibit adhesion, migration and proliferation of breast cancer cells.

The invention provides a culture medium and a method for inducing fibroblasts to be differentiated into sweat gland cells. The culture medium is prepared by adding keratinocyte growth factor (KGF) with a final concentration of 12-55mug / mL, hepatocyte growth factor (HGF) with a final concentration of 5-70ng / mL, insulin with a final concentration of 1-10ng / mL, epidermal growth factor (EGF) with a final concentration of 1-20mug / mL, nerve growth factor (NGF) with a final concentration of 18-55mug / mL, triiodothyronine with a final concentration of 1-7.5*10<-7>mol / L, and adenine with a final concentration of 2-5*10<-4>mol / L into a basic cell culture medium. By adopting the culture medium with specific components and concentrations, the single type of fibroblasts can be directly induced to be differentiated into the sweat gland cells; the method is quick and efficient, and overcomes the defect that in the traditional technology, the sweat gland cells need to be co-cultured with cells such asstem cells, so that the yield of the sweat gland cells is limited.

The invention discloses a phenyl modified material, a preparation method and an application thereof. The phenyl modified material is prepared according to the following steps: 1) adopting mercaptan containing phenyl as a solute and adopting anhydrous ethanol as a solvent to prepare a mercaptan solution with a mass concentration of 0.8-1.5%, and standing the solution for 12-24 hours at a temperature of 3-8 DEG C, wherein the molecular formula of the mercaptan containing phenyl is C6H6(CH2)nSH, and n is a positive integer; 2) growing a titanium (Ti) transition layer on a surface of a single crystal silicon wafer, and growing a gold layer on the Ti transition layer to obtain a gold-plated silicon wafer; 3) under a dark condition, adding the gold-plated silicon wafer from the step 2) to the prepared mercaptan solution from the step 1), and standing for 12-24 hours to obtain the phenyl modified material. The phenyl modified material of the present invention can inhibit adhesion, migration and proliferation of breast cancer cells.

The invention discloses a Chinese medicinal composition and application thereof. The Chinese medicinal composition is prepared from Chinese herbal medicaments, namely, rhizoma anemarrhenae and fructus forsythiae. The Chinese medicinal composition has higher action of inhibiting 5alpha-reductase compared with a single Chinese medicinal extract and can be applied to transdermal administration preparations, cosmetics or health-care food to achieve effects of treating diseases such as acne, benign prostatic hyperplasia, alopecia and the like.

The invention relates to a pet compound Shuanghuanglian granule preparation and a preparation method thereof. The pet compound Shuanghuanglian granule preparation is prepared from traditional Chinese medicine compositions such as honeysuckle, scutellaria baicalensis, forsythia, woody fragrance, citrus aurantium, magnolia officinalis, rhubarb, etc., pet palatable flavoring agents and auxiliary materials. The efficacy of stomach stagnation, especially for feline distemper has a good clinical prevention and treatment effect.

The invention discloses a medicinal liquor for treating cancer and process for preparation, wherein the main constituents include (by weight ratio) Phellinus igniarius 3-15 parts, ganoderma lucidum 3-20 parts, secretio bufonis 3-20 parts, pallas-pit viper spirit 5-50 parts, and yellow rice wine 3000-5000 parts.