A traditional Chinese medicine for replenishing qi and activating blood, softening hard masses and resolving stagnation, detoxifying and relieving pain and preparation method thereof
A technology for softening and dissipating stagnation, invigorating qi and activating blood, applied in traditional Chinese medicine for replenishing qi and activating blood, detoxifying and relieving pain and its preparation, in the field of Ruanjian and Sanjie, which can solve the problems of inconvenience for patients, increase the pain of patients, take large doses, etc., and achieve medication compliance. High, excellent curative effect, less dosage effect
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Embodiment 1
[0029] A traditional Chinese medicine for invigorating qi and activating blood circulation, softening and resolving hard masses, detoxifying and relieving pain, which is made from the following raw materials:
[0030] Panax notoginseng 4Kg, American ginseng 2Kg, Hedyotis diffusa 10Kg, Banzhilian 10Kg, Radix Paeoniae Alba 8Kg, Angelica 4Kg, Prunella vulgaris 10Kg, Bupleurum 4Kg, Citrus aurantium 4Kg, Licorice 4Kg.
[0031] The preparation method is:
[0032] 1) American ginseng and Panax notoginseng are pulverized into a fine powder with a particle size of 120 mesh (referring to fine powder that can pass through a 120 mesh sieve);
[0033] 2) Add Hedyotis diffusa and Scutellaria barbata with 5 times (weight) 60% ethanol for reflux extraction twice, combine the ethanol extracts, recover ethanol and condense it into a thick paste with a relative density of 1.3-1.35;
[0034] 3) Extract the volatile oil of Bupleurum, Citrus aurantii, and Angelica with steam distillation, decoct t...
Embodiment 2
[0075] Embodiment 2 clinical trials
[0076] 1. General information: A total of 53 patients, including 29 males and 24 females, aged between 28 and 56.
[0077] 2. Medication method: Take the capsules of Example 1, 3 times a day, 5 capsules each time, 30 days as a course of treatment.
[0078] 3. Criteria for judging curative effect:
[0079] Significant effect: cancer cells are reduced, tumors are shrunk by more than 50%, immunity is improved, energy is full, and there is no pain;
[0080] Effective: cancer cells are basically inhibited, tumors shrink by more than 30%, immunity is improved, mental health is poor, and pain is relieved;
[0081] Invalid: The cancer cells remain unchanged, the mental state is poor, there is still pain, and the symptoms are obvious.
[0082] 4. Treatment results (the observation period is 3 months):
[0083] Table 3 Clinical trial results
[0084]
[0085] The traditional Chinese medicine preparation of the present invention can be...
Embodiment 3
[0086] Embodiment 3 acute toxicity test
[0087] 1. Purpose of the experiment
[0088] 1. LD 50 Determination: Observe the toxic reaction and death situation after the capsule of Example 1 is given to animals once.
[0089] 2. MTD determination: When the toxicity of the test substance is low, LD cannot be detected 50 When the drug is used, the maximum tolerated dose can be determined once or a day, and it can also reflect the toxicity of the drug.
[0090] 2. Experimental materials
[0091] 1. 40 clean-grade Kunming mice, weighing 19-21 g, half male and half male, were provided by Hubei Experimental Animal Research Center, animal license number SCXK (E) 2008-0005. The experimental animals were kept in plastic feeding boxes, and the feed was full-price pure pellet feed provided by the Hubei Experimental Animal Research Center, and the drinking water was clean tap water.
[0092] The laboratory temperature is 19-21°C and the relative humidity is 40-60%.
[0093] 2. Drugs a...
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