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Composition containing Saxifragaceae Chrysosplenium delavayi extract and application of composition

A technology of calyx saxifrage and composition, which is applied in the field of compositions containing the extract of calyx saxifrage, can solve the problems of few saxifrage and no active ingredients found, and improve the activity of lysozyme , improve the application field and pharmacological function, and facilitate the effect of large-scale expansion

Inactive Publication Date: 2019-09-27
嘉兴市爵拓科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there are few pharmacological studies on the extracts of Saxifragaceae, especially Calyx calyx, and no active ingredients have been found.

Method used

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  • Composition containing Saxifragaceae Chrysosplenium delavayi extract and application of composition
  • Composition containing Saxifragaceae Chrysosplenium delavayi extract and application of composition
  • Composition containing Saxifragaceae Chrysosplenium delavayi extract and application of composition

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Embodiment 1

[0096] This embodiment provides a composition containing the extract of Saxifrage nephrocalyx aureus, said composition comprising:

[0097] 1) Saxifrage Nephrocalyx Golden Waist Extract;

[0098] 2) Salmonella typhimurium extracellular vesicles; and

[0099] 3) 2-[(4-tert-butylthiazol-2-yl)imino]thiazolin-4-one.

[0100] The composition of the present invention containing the extract of Calyx saxifrage has different degrees of activity inhibitory effect on 5α-reductase, especially, the inhibitory effect of the composition on type I 5α-reductase is almost comparable to that of The traditional 5α-reductase inhibitor finasteride, therefore the composition can be and / or can constitute a potential 5α-reductase inhibitor, which may lead to the development of new natural medicines for the treatment of androgen-related diseases and by different 5α-reductase causes such as hair loss, hair thinning, alopecia areata, acne, female hirsutism, hair lightening and high levels of dihydrotes...

Embodiment 2

[0142] This preferred embodiment provides a kind of saxifrage kidney calyx aureus extract, its preparation method comprises the following steps:

[0143] a) The dried whole herb of Calyx chinensis is crushed and then extracted with 75% ethanol solution, n-butanol and ethyl acetate, and the filtrate is filtered through a pinhole filter membrane, and the filtrates are combined and concentrated until there is no alcohol or ester smell ;

[0144] b) The concentrated solution is sequentially extracted with petroleum ether, ethyl acetate, acetonitrile, methanol, and chloroform to obtain five components and concentrated;

[0145] c) The concentrated solution of step b) is completely dissolved in methanol, enters the YMC C18 column, uses acetonitrile-1.1% acetic acid aqueous solution as the mobile phase, collects the components for 10 to 45 minutes, mixes and concentrates;

[0146] d) Chromatographically separate the mixed components in step c) with a medium-pressure chromatographic ...

Embodiment 3

[0153] This preferred embodiment provides a kind of saxifrage kidney calyx aureus extract, its preparation method comprises the following steps:

[0154] a) The dried whole herb of Calyx chinensis is crushed and then extracted with 75% ethanol solution, n-butanol and ethyl acetate, and the filtrate is filtered through a pinhole filter membrane, and the filtrates are combined and concentrated until there is no alcohol or ester smell ;

[0155] b) The concentrated solution is sequentially extracted with petroleum ether, ethyl acetate, acetonitrile, methanol, and chloroform to obtain five components and concentrated;

[0156] c) The concentrated solution of step b) is completely dissolved in methanol, enters the YMC C18 column, uses acetonitrile-0.1% acetic acid aqueous solution as the mobile phase, collects the components for 10 to 45 minutes, mixes and concentrates;

[0157] d) Chromatographically separate the mixed components in step c) with a medium-pressure chromatographic ...

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Abstract

The invention provides composition containing Saxifragaceae Chrysosplenium delavayi extract. The composition comprises the Saxifragaceae Chrysosplenium delavayi extract, salmonella typhimurium extracellular vesicles and 2-[(4-tert-butylthiazole-2-yl)imido] thiazoline-4-one, wherein the grain size of the salmonella typhimurium extracellular vesicles is in a range of 50-300 nm. By means of mutual compatibility of the components of the composition, the composition can have an activity inhibiting effect on 5alpha-reductase to different degrees, can be used as a 5alpha-reductase inhibitor, and can be applied to prevention and / or treatment of body discomfort such as hair loss, brittleness and easy breaking of hair, alopecia areata, acne, hair color fading and combination of the symptoms caused by 5alpha-reductase or androgen dependent diseases such as androgenic alopecia, benign prostatic hyperplasia and prostatic cancer easily caused by high-level dihydrotestosterone.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a composition containing an extract of Saxifragaceae nephrocalyx and its application. Background technique [0002] Chrysosplenium delavayi (Chrysosplenium delavayi) belongs to the perennial herb of the genus Chrysosplenium in the family Saxifragaceae, 4.5-13cm high; the sterile branches come from the leaf axils at the lower part of the stem, and the leaves are opposite, nearly oblate, with blunt round apex, and glabrous on both sides. Flower stems glabrous. Stem leaves opposite, broadly ovate, nearly round to fan-shaped, 0.22-1.5cm long, 0.3-1.6cm wide, obtuse at the apex, 7-12 crenate at the margin, wide cuneate at the base; petiole 3-7mm long. Single flower; or cyme with 2-5 flowers; inflorescence branched glabrous; bracts usually broadly ovate, 2-5mm long, 2.4-5mm, apex obtuse, margin with 6-9 crenates; pedicels 2.5-5mm long 19mm, glabrous; yellow-green flower...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61P17/14A61P13/08A61P35/00A61K35/74A61K31/427
CPCA61K31/427A61K35/74A61K36/185A61P13/08A61P17/14A61P35/00A61K2300/00Y02A50/30
Inventor 孙金纲宋艳丽代素霞
Owner 嘉兴市爵拓科技有限公司
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