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New medicinal use of Chinese medicine nutmeg and its extract

A technology of nutmeg and extract, applied in the field of traditional Chinese medicine, can solve the problems of inhibition, prevention or treatment of benign prostatic hyperplasia, etc., and achieve the effect of significant curative effect, low price, and inhibition of 5α-reductase activity

Active Publication Date: 2006-10-18
CHENGDU DIAO PHARMA GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far there has been no report that nutmeg inhibits 5α-reductase, prevents or treats benign prostatic hyperplasia and related diseases

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] The preparation of the capsule of the original powder of nutmeg of embodiment 1

[0022] The dry mature seed kernel of the traditional Chinese medicine Myristica fragrans Houtt is taken, crushed according to a conventional method, and sieved to make a fine powder of nutmeg with a particle size of 60-80 meshes. The fine powder is packed into capsules, sterilized, and packaged separately.

Embodiment 2

[0023] The preparation of embodiment 2 nutmeg extract

[0024] Weigh 1000g of nutmeg, extract three times with 90% ethanol under reflux, the amount of solvent is 8 times, 6 times, 6 times respectively, and the extraction time is 2 hours, 1 hour, 1 hour respectively. Combine the extracts and recover until there is no alcohol smell. Dry under reduced pressure at 50°C to obtain sample A. Weigh 50g of sample A and dissolve it with 150ml of distilled water. The aqueous solution was extracted with petroleum ether, diethyl ether, ethyl acetate, and n-butanol respectively with 3 times the volume, and the solvent was recovered under reduced pressure to obtain samples B (petroleum ether phase), C (ether phase), D (ethyl acetate phase), and E ( Butanol phase), F (water phase).

Embodiment 3

[0025] The preparation of embodiment 3 tablet

[0026] Composition of the tablet: Nutmeg extract A 0.5g

[0027] HPMC LV100 30g

[0028] Lactose 69g

[0029] Magnesium stearate 0.5g

[0030] Total 100g

[0031] Nutmeg extract A, HPMC LV100 , lactose, mixed with 75% ethanol as a binder to make wet granules, passed through a 22-mesh sieve, dried at 50°C for 3 hours, granulated with a 22-mesh sieve, added magnesium stearate, mixed evenly and pressed into tablets, and made into 1000 tablets, each Tablet 0.1g. Take orally, 3 times a day, 2 tablets each time.

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Abstract

The present invention relates to new medicinal use of Chinese medicine nutmeg and its extract. Specifically, nutmeg and its extract is used in preparing 5alpha-reductase inhibitor and prostatic hyperplasia treating medicine with obvious curative effect, low cost and convenient use.

Description

technical field [0001] The invention relates to a new application of the traditional Chinese medicine nutmeg, in particular to the application in the preparation of 5α-reductase inhibitors and drugs for treating benign prostatic hyperplasia, and belongs to the field of traditional Chinese medicines. Background technique [0002] Benign prostatic hyperplasia (BPH), namely prostatic hypertrophy, is a common disease in elderly men. It is characterized by static obstruction caused by benign prostatic hyperplasia and dynamic obstruction caused by increased prostate smooth muscle tension. The clinical manifestations are bladder urine outflow obstruction, Urinary urgency, frequent urination, and residual urine often lead to urinary tract infection and even induce nephritis. The incidence increases with age, and the number of incidences has also increased significantly in recent years, seriously affecting patients' physical activities and social skills, thereby affecting their qualit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9064A61P13/08
Inventor 高小平邹文俊刘忠荣李伯刚
Owner CHENGDU DIAO PHARMA GROUP
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