Method for preparing isosorbide mononitrate orally disintegrating tablets

A technology of isosorbide dinitrate and oral disintegrating tablets, which is applied in the directions of active ingredients of heterocyclic compounds, pill delivery, cardiovascular system diseases, etc., can solve the problems of inability to realize industrialized production, poor tablet compressibility, difference in tablet weight, etc. , to achieve the effect of cool and delicate taste, strong hardness, good compressibility, and small difference in tablet weight.

Inactive Publication Date: 2009-01-14
HONGYI SCI & TECH CO LTD NANCHANG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0019] In China, the preparation technology of orally disintegrating tablets started relatively late. At present, most of the orally disintegrating tablets are prepared by direct compression method. The degree of crushing, disintegration, and dissolution are difficult to control, and the compressibility of the tablet is poor, so industrial production cannot be realized

Method used

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  • Method for preparing isosorbide mononitrate orally disintegrating tablets

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0029] Isosorbide Mononitrate 10g

[0030] Mannitol 53g

[0031] Microcrystalline Cellulose 22g

[0032] Low-substituted hydroxypropyl cellulose 3g

[0033] Croscarmellose Sodium 3g

[0034] Cross-linked polyvinylpyrrolidone 3g

[0035] Micronized silica gel 3g

[0036] Magnesium Stearate 1g

[0037]

[0038] Makes 1000 pieces

[0039] Take isosorbide mononitrate and mannitol, microcrystalline cellulose, low-substituted hydroxypropyl cellulose, cross-linked carmellose sodium, cross-linked polyvinylpyrrolidone, micropowder silica gel, and magnesium stearate as auxiliary materials, and press The prescription weight ratio is mixed and sieved, and the total mixed fine powder is placed in a powder feeder for a new tablet press machine, and compressed into tablets to produce isosorbide mononitrate orally disintegrating tablets.

example 2

[0041] Isosorbide Mononitrate 10g

[0042] Mannitol 30g

[0043] Microcrystalline Cellulose 60g

[0044] Low-substituted hydroxypropyl cellulose 10g

[0045] Croscarmellose Sodium 5g

[0046] Cross-linked polyvinylpyrrolidone 5g

[0047] Micronized silica gel 5g

[0048] Magnesium Stearate 2g

[0049]

[0050] Makes 1000 pieces

[0051] Take isosorbide mononitrate and mannitol, microcrystalline cellulose, low-substituted hydroxypropyl cellulose, cross-linked carmellose sodium, cross-linked polyvinylpyrrolidone, micropowder silica gel, and magnesium stearate as auxiliary materials, and press The prescription weight ratio is mixed and sieved, and the total mixed fine powder is placed in a powder feeder for a new tablet press machine, and compressed into tablets to produce isosorbide mononitrate orally disintegrating tablets.

example 3

[0053] Isosorbide Mononitrate 10g

[0054] Lactose 55g

[0055] Microcrystalline Cellulose 23g

[0056] Croscarmellose Sodium 3g

[0057] Sodium carboxymethyl starch 6g

[0058] Cross-linked polyvinylpyrrolidone 3g

[0059] Stevia 5g

[0060] Micronized silica gel 0.2g

[0061] Magnesium stearate 0.2g

[0062]

[0063] Makes 1000 pieces

[0064] Take isosorbide mononitrate and lactose, microcrystalline cellulose, cross-linked sodium carboxymethyl cellulose, sodium carboxymethyl starch, cross-linked polyvinylpyrrolidone, stevioside, micropowder silica gel, magnesium stearate and other auxiliary materials, and press The prescription weight ratio is mixed and sieved, and the total mixed fine powder is placed in a powder feeder for a new tablet press machine, and compressed into tablets to produce isosorbide mononitrate orally disintegrating tablets.

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Abstract

The invention relates to a formula and a process of an isosorbide mononitrate orally disintegrating tablet produced with a direct powder tabletting method and a novel powder feed device for a tabletting machine. Compared with the conventional technology of the direct powder tabletting, the isosorbide mononitrate orally disintegrating tablet produced by the invention has cool and fine mouth feelings, small difference in tablet weight, favorable uniformity of content, fast disintegration and dissolution, high dissolution rate and dissolubility, strong rigidity and favorable compressibility.

Description

technical field [0001] The invention relates to a prescription and a process for producing isosorbide mononitrate orally disintegrating tablets by a direct powder compression method and a novel powder feeder for a tablet machine. Background technique [0002] Coronary heart disease angina pectoris is a common and frequently-occurring disease of the cardiovascular system. It is a clinical syndrome caused by temporary myocardial ischemia and hypoxia, with episodic chest pain or chest discomfort as the main manifestation. Angina pectoris often occurs when labor, emotional agitation or other factors increase myocardial oxygen consumption. The pain can often radiate to the left shoulder, neck pharynx or mandible, and can be relieved within a few minutes by rest or nitroglycerin. Heartbeat during angina pectoris picture Temporary ST-segment changes or T-wave changes are often seen, and coronary artery stenosis can be seen on coronary angiography. Coronary heart disease and angin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/34A61P9/10A61J3/10
Inventor 刘智钱进穆正义陶琳廖新华刘春阳熊水根陈晓华周治洋段建华颜锋刘孝乐
Owner HONGYI SCI & TECH CO LTD NANCHANG
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