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Dripping pills of perhexiline maleate and its preparation

A technology of perhexiline maleate and maleic acid, which is applied in the field of perhexiline maleate dripping pills and its preparation, can solve the problem of long disintegration time of perhexiline maleate tablets and the impact on maleic acid. The therapeutic effect of perhexiline acid and the large proportion of excipients are used to achieve good compliance, easy to carry and take, and the effect of reducing the amount of excipients

Inactive Publication Date: 2004-11-17
HONGYI SCI & TECH CO LTD NANCHANG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Perhexiline maleate tablets take a long time to disintegrate, have poor absorption, low bioavailability, and a large proportion of excipients. Children, the elderly, bedridden patients and patients with dysphagia are inconvenient to take and have poor compliance, which affects the perhexiline maleate tablets. The therapeutic effect of kexiline

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0022] prescription:

[0023] Perhexiline Maleate 5g

[0024] Macrogol 6000 15g

[0025] Makes 1000 capsules

[0026] Preparation method: take the fine powder of perhexiline maleate that has been superfinely pulverized and passed through a 200-mesh sieve, add it to the molten polyethylene glycol 6000 matrix, stir evenly, use dimethyl silicone oil as the coolant, and make pellets by the drop method. Dry and get it.

example 2

[0028] prescription:

[0029] Perhexiline Maleate 5g

[0030] Macrogol 4000 15g

[0031] Makes 1000 capsules

[0032] Preparation method: take the fine powder of perhexiline maleate that has been superfinely pulverized and passed through a 200-mesh sieve, add it to the molten polyethylene glycol 4000 matrix, stir evenly, use dimethyl silicone oil as the coolant, and make pellets by the drop method. Dry and get it.

example 3

[0034] prescription:

[0035] Perhexiline Maleate 5g

[0036] Polyethylene glycol 6000 5g

[0037] Macrogol 4000 10g

[0038] Makes 1000 capsules

[0039] Preparation method: take the fine powder of perhexiline maleate that has been superfinely pulverized and passed through a 200-mesh sieve, add it to the molten polyethylene glycol 4000 and polyethylene glycol 6000 mixed matrix, stir evenly, and use dimethyl silicone oil as cooling. Dosage, drop-making method to make pills, dry, and get it.

[0040] 4. Example 4

[0041] prescription:

[0042] Perhexiline Maleate 5g

[0043] Glyceryl Monostearate 15g

[0044] Makes 1000 capsules

[0045] Preparation method: take the fine powder of perhexiline maleate that has been superfinely pulverized and passed through a 200-mesh sieve, add it to the molten glycerol monostearate matrix, mix well, use ice water as the coolant, drop the method to make pills, and dry , tha...

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PUM

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Abstract

The invention relates to a maleic acid perhexiline drop pill prepared by utilizing ultramicro disintegration and drop pill manufacturing process, which has the advantages of improving collapse and dissolving speed, quick effect, increased medicament stability, reduced adjuvant consumption, lowered production costs, and easiness in carrying and use. It has good compliance, thus is especially suitable for children, the elderly, bedridden patients and dysphagia patients.

Description

technical field [0001] The invention relates to a pharmaceutical preparation and a preparation method thereof, in particular to perhexiline maleate dropping pills and a preparation method thereof. Background technique [0002] Perhexiline maleate can dilate coronary vessels, increase coronary flow, reduce left ventricular load, and reduce myocardial oxygen consumption. It has antiarrhythmic, diuretic and bronchodilatory effects. For patients with heart failure and bronchospasm, it can reduce the frequency of angina pectoris and reduce the dosage of nitroglycerin. [0003] Perhexiline maleate is absorbed from the gastrointestinal tract, slowly metabolized, and excreted in urine and feces. Half-life (t 1 / 2 ) in the range of 3 to 12 days. Clinically used for angina pectoris and arrhythmia. [0004] Perhexiline maleate tablets have a long disintegration time, poor absorption, low bioavailability, and a large proportion of excipients. Children, the elderly, bedridden patient...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/4458A61P7/10A61P9/06A61P9/08A61P9/10
Inventor 钱进许军彭红李平朱丹刘孝乐
Owner HONGYI SCI & TECH CO LTD NANCHANG
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