32 results about "Perhexiline" patented technology

The invention discloses a preparation method of a perhexiline pharmaceutical preparation, comprising the following steps of: (a) preparing pharmaceutical components salvia and szechuan lovage rhizome, wherein the weight ratio of salvia to szechuan lovage rhizome 1-3: 1-3 by weight; (b) decocting the salvia, injecting concentrated liquor in a macroporous absorption resin column, and concentrating and drying eluent to obtain salvia extractive; (c) decocting the szechuan lovage rhizome, injecting concentrated liquor in a macroporous absorption resin column, and concentrating and drying eluent to obtain szechuan lovage rhizome extractive; and (d) adding pharmacologically allowed pharmaceutical carriers in the prepared extractives uses as active ingredients to prepare various forms of pharmaceutical preparation. The perhexiline pharmaceutical preparation prepared by the method disclosed in the invention has effect superior to that of the perhexiline pharmaceuticals prepared according to the prior art.

A method and composition are provided for the treatment of an anorectal disorder and for controlling the pain associated therewith. The method comprises administering to a subject in need of such treatment therapeutically effective amounts of a calcium channel blocker either alone or together with a nitric oxide donor. Amlodipine, anipamil, barnidipine, benidipine, bepridil, darodipine, diltiazem, efonidipine, felodipine, isradipine, lacidipine, lercanidipine, lidoflazine, manidipine, mepirodipine, nicardipine, nifedipine, niludipine, nilvadipine, nimodipine, nisoldipine, nitrendipine, perhexiline, tiapamil, verapamil and pharmaceutically acceptable salts thereof, are suitable calcium channel blockers.

The invention discloses a perhexiline injection liquid and a preparation method thereof, wherein the perhexiline injection liquid is prepared from radix salviae miltiorrhizae, ligusticum chuanxiong, sodium metabisulfite, sodium calcium edetate, HS-15 and water for injection. The preparation method of the perhexiline injection liquid comprises the steps: adding water to radix salviae miltiorrhizae and ligusticum chuanxiong, decocting, filtering the decoction, concentrating, carrying out precipitation treatment for 2 times with ethanol, filtering, concentrating the filtrate, diluting with water for injection, regulating the pH value with dilute hydrochloric acid, refrigerating, filtering, regulating the pH value with a sodium hydroxide solution, concentrating the filtrate, refrigerating, and filtering to obtain a solution 1; taking 100 ml of water for injection, adding sodium calcium edetate and sodium metabisulfite, stirring until being dissolved, and filtering with activated carbon to obtain a solution 2; adding the HS-15 into 100 ml of water for injection, evenly stirring to obtain a solution 3; and merging the three solutions, filtering, regulating the pH value, adding water for injection to the full amount, filling and sealing, and thus obtaining the product. With adopting of the new prescription and process, the perhexiline injection liquid has an outstanding advantage of greatly enhancing the medication security of the perhexiline injection liquid.

The invention discloses application of perhexiline/oxaliplatin drug combination in the aspect of treatment of stomach cancer and colorectal cancer. The research shows that the perhexiline is capable of obviously inhibiting the growth, proliferation and clone formation capacities of the stomach cancer and colorectal cancer cells, inducing the apoptosis of the stomach cancer and colorectal cancer cells and inhibiting the invasion and transfer capacities of the stomach cancer and colorectal cancer cells, has obvious treatment effects on stomach cancer and colorectal cancer, and therefore, can be used in drugs for treating stomach cancer and intestinal cancer. The invention provides new application of perhexiline, thereby widening the clinical application fields of perhexiline; and the invention also provides a new scheme of perhexiline/oxaliplatin drug combination in treating stomach cancer and colorectal cancer, thereby increasing the options for chemotherapeutic schemes of stomach cancer and colorectal cancer, and having favorable clinical application prospects.

The invention discloses a method for detecting macromolecular substances in a perhexiline injection. The method after being subjected to a series of investigation, testing and verification of specificity and linearity investigation, degree of precision, stability and the like, can detect the macromolecular substances in the perhexiline injection easily, conveniently and quickly. From an HPLC (High Performance Liquid Chromatography) spectrum, macromolecular substances with molecular weight greater than 2500 are not detected in five batches of detected perhexiline injection samples.

The invention relates to a peltate leaf perhexiline oral cavity disintegrating tablet which is prepared by the following raw materials in parts by weight: 100-800 peltate leaf dioscorea rhizome extract, 50-300 filling agent, 20-150 disintegrating agent, 1-15 glidant and 1-8 flavoring agent. A preparation method of the peltate leaf perhexiline oral cavity disintegrating tablet comprises the following steps: respectively pulverizing the peltate leaf dioscorea rhizome extract, the filling agent, the disintegrating agent, the glidant and the flavoring agent and screening by a sieve in 50-100 meshes; then mixing all raw material powders; tabletting and preparing a finished product. The peltate leaf perhexiline oral cavity disintegrating tablet has the advantages of rapid disintegration and absorption, good taste, high bioavailability, quite convenient taking and simple and convenient preparation process and more rapid disintegration and dissolution of main medicine components, is more suitable for the emergency treatment of an acute patient, such as an angina patient and enters the gastrointestinal tract to rapidly disperse and widely cover the gastrointestinal mucosal after being disintegrated.

The invention relates to a maleic acid perhexiline drop pill prepared by utilizing ultramicro disintegration and drop pill manufacturing process, which has the advantages of improving collapse and dissolving speed, quick effect, increased medicament stability, reduced adjuvant consumption, lowered production costs, and easiness in carrying and use. It has good compliance, thus is especially suitable for children, the elderly, bedridden patients and dysphagia patients.

The invention discloses a perhexiline injection which is prepared from the following raw materials in parts by weight: 1900-2100 parts of radix salviae miltiorrhizae, 1900-2100 parts of hemlock parsley, 0.4-3.8 parts of cosolvent, 0.3-1.8 parts of stabilizer and 4000-6000 parts of water for injection. The perhexiline injection has the effects of activating blood circulation to dissipate blood stasis, promoting circulation of qi and nourishing the heart, is used for coronary heart disease and angina pectoris, has favorable stability, and thus, has favorable application prospects.

The invention belongs to the field of traditional Chinese medicine preparations and specifically discloses a detection method for content of a peltate leaf perhexiline preparation. The method is a content detection method established on the basis of taking zingiberensis newsaponin as an index component. The peltate leaf perhexiline preparation is a traditional Chinese medicine preparation taking peltate yam rhizome extract as a prescription and has the effects of promoting circulation and removing stasis, promoting qi circulation to relieve pain and nourishing the blood and soothing the nerves. The peltate leaf perhexiline preparation is used for treating patients suffering the symptoms of thoracic obstruction, cardiodynia Qi depression blood stasis, hyperlipemia, coronary heart disease and stenocardia. According to the content detection method disclosed by the invention, an evaporation light scattering detector is used for detecting and a high performance liquid chromatography is used for detecting the content of zingiberensis newsaponin. The method is accurate, the stability is high, the quality controllability of the peltate leaf perhexiline preparation is increased, the effectiveness of the medicine is ensured, and standardized production of the medicine can be conveniently realized.

A synthesis method of a perhexiline drug intermediate alpha-(2,2-diphenyl vinyl) pyridine includes the following steps that 1.56 mol of 1,1-diphenyl-2-(alpha-pyridyl) ethylamine, 1.8-2.1 mol of a hypochlorous phenyl ester solution and 300 ml of nitromethane are added into a reaction vessel provided with a stirrer, a reflux condenser, a thermometer and a dropping funnel, the stirring speed is controlled to be 150-190 rpm, the solution temperature is raised to 80-85 DEG C, reaction is performed for 3-5 hours, the solution temperature is reduced to 45-50 DEG C, a potassium carbonate solution is added to regulate the pH to 9-10, continuous stirring is performed for reaction for 5-7 hours, the solution temperature is reduced to 10-15 DEG C, solid precipitation, suction filtration, washing with a saline solution, washing with chlorobenzene and decoloration with a molecular sieve are performed, stirring reflux is performed for 3-4 hours, a dehydrating agent is adopted fordehydration, and recrystallization is performed in p-xylene to obtain the crystal alpha-(2,2-diphenyl vinyl) pyridine.

Methods are provided for preventing, reducing, and/or treating contrast-induced acute kidney injury which include administering an inhibitor of fatty acid oxidation to a patient in need thereof. Also provided are methods involving use of trimetazidine or pharmaceutically acceptable salts thereof for the prevention and/or treatment of contrast-induced acute kidney injury. Methods are also provided for preventing and/or treating contrast-induced acute kidney injury which include administration of one or more of trimetazidine, etomoxir, oxfenicine, perhexiline, mildronate, or ranolazine, or pharmaceutically acceptable salts of any of the preceding.

The present invention discloses a Guanxinning injection for effectively curing coronary heart disease and ischemic cerebrovascular disease. It is characterized by that said injection is basically formed from tanshinone, salvia phenol acid matter, liguistrazine and ligusticum pherol acid ester matter. Besides, said invention also provides its preparation method by utilizing fresh salvia root and ligusticum root and its concrete steps. It is characterized by that the invented injection not only contains tanshinone II A and ligustrazine, but also contains cryptotanshinone, tanshinone I, salvia phenol acid matter and ligusticum phenol acid ester matter.

The invention discloses a perhexiline capsule and a preparation method thereof. The perhexiline capsule is characterized in that 155 g of nutmeg, 77.5 g of eupatorium, 1080 g of pubescent holly roots, 540 g of ginkgo leaves, 330 g of motherwort and 330 g of herba siegesbeckiae are taken, a carbon dioxide supercritical extraction method is adopted for extraction, drying is performed under reduced pressure, the materials are smashed into nano dry paste through a high-energy nano impacting mill, functional auxiliaries are added, the perhexiline capsule is prepared, the disintegrating time is remarkably shortened, the curative effect is remarkably superior to that of perhexiline capsules sold on the market, and a positive effect is achieved.