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Perhexiline injection

A technology of injection and Guanxinning, which is applied in the fields of cardiovascular system diseases, plant raw materials, inorganic inactive ingredients, etc., can solve the problems of difficult storage for a long time and poor stability, and achieves good application prospects and good stability.

Inactive Publication Date: 2017-02-01
上海辰松新材料科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the Guanxinning injection prepared by the prior art has poor stability and is not easy to store for a long time

Method used

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  • Perhexiline injection
  • Perhexiline injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Guanxinning injection raw materials: Salvia miltiorrhiza 2000g, Chuanxiong 2000g, co-solvent 0.48g, stabilizer 0.39g, water for injection 4200g.

[0026] The co-solvent is obtained by uniformly stirring and mixing glycine, 1,2-propanediol and mannitol in a mass ratio of 1:1:1.

[0027] The stabilizer is obtained by stirring and uniformly mixing sodium sulfite, sodium lactate and sodium metabisulfite in a mass ratio of 1:1:1.

[0028] The preparation method of above-mentioned Guanxinning injection comprises the following steps:

[0029] (1) Take 2000g of Salvia miltiorrhiza, crush it to 10 mesh, add 10000g of water to decoct 3 times each time, 2 hours for the first time, 1.5 hours for the second and third times, combine the decoction, filter with 180 mesh filter cloth, reduce Press back the water to one-tenth of the original volume (that is, one-tenth of the total volume of the decoction for 3 times) to obtain a concentrated solution, and inject the obtained concentrate...

Embodiment 2

[0033] It is basically the same as in Example 1, except that the co-solvent is obtained by stirring and mixing uniformly glycine and 1,2-propanediol at a mass ratio of 1:1. Obtain the Guanxinning injection of embodiment 2.

Embodiment 3

[0035] It is basically the same as in Example 1, except that the co-solvent is obtained by stirring and mixing uniformly 1,2-propanediol and mannitol at a mass ratio of 1:1. Obtain the Guanxinning injection of embodiment 3.

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PUM

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Abstract

The invention discloses a perhexiline injection which is prepared from the following raw materials in parts by weight: 1900-2100 parts of radix salviae miltiorrhizae, 1900-2100 parts of hemlock parsley, 0.4-3.8 parts of cosolvent, 0.3-1.8 parts of stabilizer and 4000-6000 parts of water for injection. The perhexiline injection has the effects of activating blood circulation to dissipate blood stasis, promoting circulation of qi and nourishing the heart, is used for coronary heart disease and angina pectoris, has favorable stability, and thus, has favorable application prospects.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to Guanxinning injection. Background technique [0002] Guanxinning Injection is a brownish-red clear liquid, which is obtained by mixing and extracting Danshen and Chuanxiong. It has the functions of promoting blood circulation and removing blood stasis, dilating coronary arteries, increasing coronary blood volume, accelerating the repair of ischemic myocardium, promoting regeneration of infarcted myocardium, and improving microcirculation. Clinically, it is mainly used for the treatment of coronary heart disease, angina pectoris, cerebral thrombosis and other cardiovascular and cerebrovascular diseases, as well as liver and kidney diseases. Phenolic acids, such as danshensu (DSS), protocatechuic acid (PA), caffeic acid (CA), ferulic acid (FA), rosmarinic acid (RA), shikonian acid (LA), salvianolic acid B (SaB) and salvianolic acid A (SaA) are co...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K47/18A61K47/10A61K47/26A61K47/02A61K47/12A61K36/537A61P9/10
CPCA61K9/08A61K9/0019A61K36/236A61K36/537A61K47/02A61K47/10A61K47/12A61K47/183A61K47/26A61K2300/00
Inventor 刘世超
Owner 上海辰松新材料科技有限公司
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