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Detection method for content of peltate leaf perhexiline preparation

A detection method, the technology of Guanxinning, which is applied to the content detection of the traditional Chinese medicine preparation Dunye Guanxinning for the prevention and treatment of cardiovascular diseases, and the field of content determination of the active ingredient dunphylloside in the preparation of Dunye Guanxinning, which can solve the problem that there are no varieties of the preparation of Dunye Guanxinning. Content determination, no content determination items, etc., to achieve the effects of facilitating standardized production of drugs, improving quality controllability, and accuracy and stability

Inactive Publication Date: 2016-08-17
江苏黄河药业股份有限公司
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Problems solved by technology

In addition, Dunye Guanxinning Tablets is the exclusive traditional Chinese medicine variety of Jiangsu Huanghe Pharmaceutical Co., Ltd., and its standards are recorded in Volume 17 of the Ministry of Health's Drug Standards for Traditional Chinese Medicine Prescriptions. The standard number is WS 3 -B-3282-98, there is no content determination item in the standard, and there is no relevant literature report on the content determination of the variety of Dunye Guanxinning preparations

Method used

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  • Detection method for content of peltate leaf perhexiline preparation
  • Detection method for content of peltate leaf perhexiline preparation
  • Detection method for content of peltate leaf perhexiline preparation

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Embodiment

[0028] 1. Instruments and reagents

[0029] Instruments: high performance liquid chromatography: Agilent 1200; Aotai 3300 evaporative light scattering detector; XS205 electronic balance (Mettler Toledo, Switzerland); KH-500DE ultrasonic cleaner (Kunshan Hechuang Ultrasonic Instrument Co., Ltd.).

[0030] Reagents: Methanol and acetonitrile are chromatographically pure, water level ultrapure water, and other chemical reagents are analytically pure.

[0031] Reference substance: glucoside, with a purity of 98.0%, provided by Baoji Chenguang Biotechnology Co., Ltd.

[0032] Test product: Dunye Guanxinning Tablets, provided by Jiangsu Huanghe Pharmaceutical Co., Ltd.

[0033] Negative samples of Dunye Guanxinning Tablets: the prescription lacks Dunye Guanxinning Tablets, and the other excipients are prepared according to the preparation method of Dunye Guanxinning Tablets, provided by Jiangsu Huanghe Pharmaceutical Co., Ltd.

[0034] 2. Chromatographic conditions

[0035] Colum...

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Abstract

The invention belongs to the field of traditional Chinese medicine preparations and specifically discloses a detection method for content of a peltate leaf perhexiline preparation. The method is a content detection method established on the basis of taking zingiberensis newsaponin as an index component. The peltate leaf perhexiline preparation is a traditional Chinese medicine preparation taking peltate yam rhizome extract as a prescription and has the effects of promoting circulation and removing stasis, promoting qi circulation to relieve pain and nourishing the blood and soothing the nerves. The peltate leaf perhexiline preparation is used for treating patients suffering the symptoms of thoracic obstruction, cardiodynia Qi depression blood stasis, hyperlipemia, coronary heart disease and stenocardia. According to the content detection method disclosed by the invention, an evaporation light scattering detector is used for detecting and a high performance liquid chromatography is used for detecting the content of zingiberensis newsaponin. The method is accurate, the stability is high, the quality controllability of the peltate leaf perhexiline preparation is increased, the effectiveness of the medicine is ensured, and standardized production of the medicine can be conveniently realized.

Description

technical field [0001] The invention belongs to the technical field of drug analysis, and in particular relates to a method for detecting the content of dunyeguanxinning, a traditional Chinese medicine preparation for preventing and treating cardiovascular diseases. Background technique [0002] The traditional Chinese medicine preparation for the prevention and treatment of cardiovascular diseases, which is prepared with the extract of Dioscorea baicalensis, has the effects of promoting blood circulation and removing blood stasis, promoting qi and relieving pain, nourishing blood and calming the nerves. It is used for the treatment of thoracic obstruction and heartache which belong to Qi stagnation and blood stasis syndrome, hyperlipidemia, as well as coronary heart disease and angina pectoris with the above symptoms. The prevention and treatment effect of Dioscorea scutellaria scutellariae on myocardial ischemia was studied by coronary artery ligation in rats. Significant...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02
CPCG01N30/02G01N2030/027
Inventor 何枢衡唐俊朱正标陶元明马博张汉华
Owner 江苏黄河药业股份有限公司
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