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Peltate leaf perhexiline oral cavity disintegrating tablet and preparation method thereof

A technology of orally disintegrating tablets and Guanxinning, applied in the field of Dunye Guanxinning orally disintegrating tablets and its preparation, can solve the problems of inconvenient use, large dosage at one time, and slow drug dissolution rate, etc., and achieve disintegration Good performance, fast onset, fast disintegration and dissolution

Inactive Publication Date: 2010-02-17
石庆平
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are only tablets for Dunye Guanxinning in the market, and the existing tablets have the following disadvantages: the dissolution rate of the drug is relatively slow, and the bioavailability is low; it is inconvenient to take orally for water supply; the dosage is large at one time, and the frequency of administration is high. Big
Secondly, the existing dosage forms are not very convenient for the elderly who have certain difficulties in swallowing. Many elderly or emergency patients with weak swallowing ability are unwilling to take or cannot take these solid preparations, and complain of difficulty in swallowing or esophageal obstruction

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] The raw materials were weighed according to the following weight ratio: 160g of Dioscorea scutellaria rhizome extract, 100g of microcrystalline cellulose, 40g of mannitol, 20g of low-substituted hydroxypropyl cellulose, 50g of cross-linked vinylpyrrolidone, 8g of citric acid, bicarbonate Sodium 8g, talcum powder 4g, stevioside 4g, sour strawberry 2g.

[0021] Preparation method: crush each of the above raw materials and pass through a 100-mesh sieve; then directly mix the powders of each raw material; compress the uniformly mixed powder into tablets to obtain orally disintegrating tablets of Dunye Guanxinning with a tablet weight of 0.396 g.

[0022] Test result: Tablet hardness: 2.5~5Kg

[0023] Disintegration time limit: 20-50 seconds

[0024] Good taste, no gritty and unpleasant taste, no foreign body feeling.

Embodiment 2

[0026] Weigh each raw material according to the following weight ratio: 320g of Dioscorea scutellaria rhizome extract, 60g of microcrystalline cellulose, 60g of xylitol, 60g of mannitol, 5g of croscarmellose sodium, low-substituted hydroxypropyl cellulose 10g, cross-linked vinylpyrrolidone 10g, sodium bicarbonate 5g, citric acid 5g, aspartame 3g, mint essence 3g, magnesium stearate 4g

[0027] Preparation method: crush each of the above raw materials and pass through a 100-mesh sieve; then directly mix the powders of each raw material; compress the uniformly mixed powder into tablets to obtain orally disintegrating tablets of Dunye Guanxinning with a tablet weight of 0.545 g.

[0028] Test result: Tablet hardness: 2.5~5Kg

[0029] Disintegration time limit: 15 to 50 seconds

[0030] Good taste, no gritty and unpleasant taste, no foreign body feeling.

Embodiment 3

[0032] Weigh each raw material according to the following weight ratio: 160g of Dioscorea scutellaria rhizome extract, 5g of lactose, 80g of microcrystalline cellulose, 20g of xylitol, 8g of low-substituted hydroxypropyl cellulose, 5g of cross-linked vinylpyrrolidone, sodium bicarbonate 5g, citric acid 5g, aspartame 3g, peppermint essence 3g, magnesium stearate 4g.

[0033] Preparation method: crush each of the above raw materials and pass through a 100-mesh sieve; then directly mix the powders of each raw material; compress the uniformly mixed powder into tablets to obtain orally disintegrating tablets of Dunye Guanxinning with a tablet weight of 0.298 g.

[0034] Test result: Tablet hardness: 2.5~5Kg

[0035] Disintegration time limit: 20-50 seconds

[0036] Good taste, no gritty and unpleasant taste, no foreign body feeling.

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Abstract

The invention relates to a peltate leaf perhexiline oral cavity disintegrating tablet which is prepared by the following raw materials in parts by weight: 100-800 peltate leaf dioscorea rhizome extract, 50-300 filling agent, 20-150 disintegrating agent, 1-15 glidant and 1-8 flavoring agent. A preparation method of the peltate leaf perhexiline oral cavity disintegrating tablet comprises the following steps: respectively pulverizing the peltate leaf dioscorea rhizome extract, the filling agent, the disintegrating agent, the glidant and the flavoring agent and screening by a sieve in 50-100 meshes; then mixing all raw material powders; tabletting and preparing a finished product. The peltate leaf perhexiline oral cavity disintegrating tablet has the advantages of rapid disintegration and absorption, good taste, high bioavailability, quite convenient taking and simple and convenient preparation process and more rapid disintegration and dissolution of main medicine components, is more suitable for the emergency treatment of an acute patient, such as an angina patient and enters the gastrointestinal tract to rapidly disperse and widely cover the gastrointestinal mucosal after being disintegrated.

Description

technical field [0001] The invention relates to Dunye Guanxinning and a preparation method thereof, in particular to an orally disintegrating tablet of Dunye Guanxinning which can rapidly disintegrate and release medicine in the oral cavity and a preparation method thereof. Background technique [0002] Dunye Guanxinning is the rhizome extract of Dioscorea dioscorea, which has simple ingredients and low cost. It has the effects of promoting blood circulation and removing blood stasis, promoting qi and relieving pain. hyperlipidemia etc. Studies have shown that Dunye Guanxinning Tablet has definite curative effect and high safety in treating angina pectoris of coronary heart disease, and is a good medicine for treating angina pectoris of coronary heart disease. At present, there are only tablets for Dunye Guanxinning in the market, and the existing tablets have the following disadvantages: the dissolution rate of the drug is relatively slow, and the bioavailability is low; i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8945A61K9/20A61P9/10A61K125/00
Inventor 石庆平丁峰许善初刘雁程鹏朱锦秀郭辉
Owner 石庆平
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