Method for preparing perhexiline pharmaceutical preparation
The technology of a pharmaceutical preparation, Guanxinning, is applied in the field of preparation of traditional Chinese medicine preparations, which can solve problems such as difficult quality control and poor drug stability, and achieve the effects of improving drug efficacy, increasing coronary artery flow and myocardial blood flow, and improving myocardial ischemia. Effect
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Embodiment 1
[0022] Take 20000g of Salvia miltiorrhiza, crush it, add 6 times the amount of crude drug to decoct 3 times, the first time for 2 hours, the second and third times for 1.5 hours each, combine the decoction, filter, recover under reduced pressure, and inject the obtained concentrated solution into D101 type macroporous adsorption resin column, first eluted with purified water of 6 times the volume of the column, then eluted with 15% (v / v) ethanol of 6 times the volume of the column, discarded the eluent, and then used 60% ( v / v) ethanol elution, collecting 5 times the column volume of the eluent; concentrating the obtained eluent, drying, and pulverizing to obtain the salvia miltiorrhiza extract;
[0023] Take 20000g of Rhizoma Chuanxiong medicinal material, pulverize, add 60% (v / v) ethanol of 6 times the amount of crude drug, and heat and reflux extraction for 3 times, each time for 2 hours; combine the extracts, recover the solvent under reduced pressure; inject the obtained c...
Embodiment 2
[0032] Take 20,000g of Salvia miltiorrhiza, crush it, add 8 times the crude drug amount of water and decoct twice, the first time for 2 hours, and the second time for 1.5 hours, combine the decoction, filter, recover under reduced pressure, and inject the obtained concentrated solution into the HPD100 large Pore adsorption resin column, first eluted with purified water of 5 times the volume of the column, then eluted with 20% ethanol of 4 times the volume of the column, discarded the eluent, and then eluted with 80% alcohol, collected 6 times the volume of the column volume of eluate; the obtained eluate is concentrated, dried and pulverized to obtain the salvia miltiorrhiza extract;
[0033] Take 20000g of Rhizoma Chuanxiong medicinal material, pulverize, add 80% ethanol of 8 times the amount of crude drug, heat and reflux extraction twice, each time for 2 hours; combine the extracts, recover the solvent under reduced pressure; inject the obtained concentrated solution into ...
Embodiment 3
[0041] Take 2000g of Salvia miltiorrhiza, crush it, add 5 times the crude drug amount of water and decoct 4 times, the first time for 2 hours, the second and third times for 1.5 hours each, and the fourth time for 1 hour each, combine the decoction, filter, and recover under reduced pressure , the concentrated solution obtained is injected into the HP-20 type macroporous adsorption resin column, first eluted with purified water of 7 times the volume of the column, then eluted with 20% ethanol 8 times the volume of the column, discarded the eluent, and then Elute with 75% ethanol, collect 8 times the column volume of the eluate; concentrate the obtained eluate, dry, and pulverize to obtain the salvia miltiorrhiza extract;
[0042] Take 2000g of Rhizoma Chuanxiong medicinal material, pulverize, add 70% ethanol of 10 times the amount of crude drug, heat and reflux extraction for 3 times, each time for 2 hours; combine the extracts, recover the solvent under reduced pressure; injec...
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