Perhexiline injection liquid and preparation method thereof

Abstract

The invention discloses a perhexiline injection liquid and a preparation method thereof, wherein the perhexiline injection liquid is prepared from radix salviae miltiorrhizae, ligusticum chuanxiong, sodium metabisulfite, sodium calcium edetate, HS-15 and water for injection. The preparation method of the perhexiline injection liquid comprises the steps: adding water to radix salviae miltiorrhizae and ligusticum chuanxiong, decocting, filtering the decoction, concentrating, carrying out precipitation treatment for 2 times with ethanol, filtering, concentrating the filtrate, diluting with water for injection, regulating the pH value with dilute hydrochloric acid, refrigerating, filtering, regulating the pH value with a sodium hydroxide solution, concentrating the filtrate, refrigerating, and filtering to obtain a solution 1; taking 100 ml of water for injection, adding sodium calcium edetate and sodium metabisulfite, stirring until being dissolved, and filtering with activated carbon to obtain a solution 2; adding the HS-15 into 100 ml of water for injection, evenly stirring to obtain a solution 3; and merging the three solutions, filtering, regulating the pH value, adding water for injection to the full amount, filling and sealing, and thus obtaining the product. With adopting of the new prescription and process, the perhexiline injection liquid has an outstanding advantage of greatly enhancing the medication security of the perhexiline injection liquid.

Description

technical field

[0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a Guanxinning injection and a preparation method thereof. Background technique

[0002] Guanxinning injection is a traditional Chinese medicine preparation containing effective extracts of Danshen and Chuanxiong. It has been on the market in China for more than 30 years. It is often used in the treatment of cardiovascular and cerebrovascular diseases in clinical practice.

[0003] Guanxinning Injection is one of the commonly used drugs in clinical practice. It is recorded in the instructions that there are occasional adverse reactions such as urticaria, wheal, angioedema, and allergic asthma. Among them, allergic reactions are the most prominent adverse reactions of Guanxinning. People with history of allergies are forbidden to use this medicine. After investigation, most of the co-solvents of Guanxinning injection currently available on the market are polyso...