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Perhexiline high-dose injection and its preparing method

An injection and large-capacity technology, which is applied in the field of pharmaceuticals, can solve problems such as low quality standards of preparations, incomplete extraction of active ingredients, and unscientific extraction processes, and achieve the goal of overcoming unscientific extraction processes, avoiding secondary pollution, and being convenient to use Effect

Inactive Publication Date: 2006-08-09
孟繁浩
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Overcome the unscientific extraction process of Guanxinning Injection, incomplete extraction of active ingredients, difficulty in product quality control, and low preparation quality standards.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] [Prescription] Danshen 2000g, Chuanxiong 2000g

[0016] [Preparation method] The above two flavors are decocted with water for three times, the first time is 2 hours, the second and third times are 1.5 hours each, the decoctions are combined, filtered, the filtrate is concentrated to about 2000ml, and the second time is treated with ethanol precipitation. Make the alcohol content reach 75% for the first time, and 85% for the second time. After adding ethanol each time, place it in cold storage, filter, combine the filtrate, concentrate to about 700ml, dilute to 4000ml with water for injection, and adjust the pH value to 3.2; Refrigerate, filter, adjust the pH value to 6.8 with 10% sodium hydroxide solution, concentrate to 1000ml, refrigerate, filter, then adjust the pH value to 6.8, add 250g of glucose, boil for 30 minutes, add 0.2% activated carbon, slightly Cool, filter, adjust the pH value of the filtrate to 6.8, add water for injection to make 5000ml, fill and steri...

Embodiment 2

[0018] [Prescription] Danshen 2000g, Chuanxiong 2000g

[0019] [Preparation method] Mix the above two flavors, add water and decoct three times, the first time for 2 hours, the second and third times for 1.5 hours each, combine the decoction, filter, concentrate the filtrate to about 2000ml, and use ethanol precipitation treatment twice, Make the alcohol content reach 75% for the first time, and 85% for the second time. After adding ethanol each time, place it in cold storage, filter, combine the filtrate, concentrate to about 700ml, dilute to 4000ml with water for injection, and adjust the pH with dilute hydrochloric acid value to 3.2; refrigerate, filter, adjust the pH value to 6.0-7.0 with 5% sodium hydroxide solution, concentrate to 1000ml, refrigerate, filter, then adjust the pH value to 7.0-8.0, boil for 30 minutes, add glucose 500g, Dissolve, add activated carbon, filter, adjust the pH value of the filtrate to 7.0-8.0, add water for injection to make 10000ml, fill, ster...

Embodiment 3

[0021] [Prescription] Danshen 2000g, Chuanxiong 3000g

[0022] [Preparation method] The above two flavors are crushed, mixed, and decocted with water for three times, the first time is 2 hours, the second and third time are 1.5 hours each, the decoction is combined, filtered, the filtrate is concentrated to about 3000ml, and ethanol is used for precipitation treatment. For the first time, the alcohol content reached 50% for the first time, and for the second time it was 85%. After each addition of ethanol, it was refrigerated and placed, filtered, and the filtrate was combined, concentrated to about 1000ml, diluted to 5000ml with water for injection, and diluted with dilute hydrochloric acid. Adjust the pH value to 3.0-3.5; refrigerate, filter, adjust the pH value to 6.5-7.0 with 20% sodium hydroxide solution, concentrate to 1000ml, refrigerate, filter, then adjust the pH value to 6.5-7.0, add 500g of glucose, Boil for 30 minutes, add activated carbon, cool slightly, filter, a...

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Abstract

The present invention discloses a Guanxinning large-volume injection and its preparation method. It is characterized by that after the Chinese medicinal materials of salvia root and ligusticum root are extracted and purified, their purified extracts are combined with medicinal auxiliary material so as to obtain the invented large-volume injection.

Description

technical field [0001] The invention belongs to the field of medicines, and relates to a large-capacity injection of Guanxinning with traditional Chinese medicines salvia miltiorrhiza and chuanxiong as raw materials and a preparation method thereof. technical background [0002] Salvia miltiorrhiza is the dry root and rhizome of Salvia miltiorrhiza Bge. Bitter in the mouth, cold in nature. It has the functions of promoting blood circulation and removing blood stasis, reducing swelling and relieving pain, nourishing blood and calming the nerves. It is used for irregular menstruation, dysmenorrhea, amenorrhea, lump in the abdomen, postpartum stasis, chest and abdomen or limb stasis pain, carbuncle sores, upset and insomnia. [0003] Salvia miltiorrhiza was first recorded in "Shen Nong's Materia Medica", listed as top grade, and all herbal medicines in successive dynasties have been recorded. Also known as "red ginseng" in "Famous Doctors", it is named because of its red roo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/537A61K9/08A61P9/10
Inventor 孟繁浩
Owner 孟繁浩
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