Diacetyl rhein dropping pills and its preparing process

A technology of diacetyl rhein and dropping pills, which is applied in the field of drug exploration, can solve the problems of adverse effects on drug quality stability, shortened validity period and shelf life, and easy corruption, and achieves the effects of increased stability, long validity period, and difficulty in hydrolysis

Inactive Publication Date: 2007-08-15
上海慈瑞医药科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, due to the large proportion of liquid carrier oils such as vegetable oil and animal oil used in the preparation, vegetable oil and animal oil are easi

Method used

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  • Diacetyl rhein dropping pills and its preparing process
  • Diacetyl rhein dropping pills and its preparing process

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Experimental program
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Embodiment 1-9

[0018] The present invention prepares diacetyl rhein with different substrates, and investigates indicators such as roundness, pill weight difference, hardness, dissolution time, etc., so as to determine the weight ratio of diacetyl rhein to single or mixed substrates.

[0019] Table 1 Proportion test of diacetylrhein and different substrates (1 part of diacetylrhein)

[0020] Its process is:

[0021] The first step. Take diacetyl rhein, pulverize, and sieve to 60-200 mesh / hour;

[0022] Step 2. Take 1 part of pulverized diacetyl rhein, add the dropping pill matrix in the above table, stir while heating until melting, and the heating temperature is 80°C;

[0023] Step 3. Move the molten material from step 2 to the dripping pill machine, keep the temperature of the drug material and dripper at 80°C, drop it into the dripping pill coolant while stirring, the cooling temperature is 4°C, and the dropping speed is 40± 10 grains per minute, the dropping pills are separated fro...

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Abstract

This invention relates to a dripping pill of diacetyl rhein. the pill is characterised in that it is prepared from diacetyl rhein and dripping pill substrate at a weight ratio of 1:1-5. the preparation method comprises pulverizing diacetyl rhein, adding substrate, heating, stirring to fusion, moving to a dripping pill engine with the temperature of materials and dripper at 75-85deg.C, stirring, dripping into coolant at 0-6deg.C and speed of 40+-10 pill/min, separating the dripping pill and coolant through a separating unit, and dripping to obtain the final product. The invention has the advantages of few air contact, uneasy oxidation, no hydrolysis, increase medicine stability, and improved shelf life.

Description

technical field [0001] The invention relates to a diacetyl rhein dripping pill and a preparation method thereof, which are used for treating symptoms such as pain and joint dysfunction caused by degenerative arthritis and related diseases, and belong to the technical field of drugs. Background technique [0002] Diacetylrhein, chemical name 4,5-diacetyl-9,10-dihydro-9,10-dioxo-2-anthracene carboxylic acid, also known as Diacerein (Diacerein), for osteoarthritis IL-1 Inhibitor, can induce cartilage production, has analgesic, anti-inflammatory and antipyretic effects. It is clinically used to treat symptoms such as pain and joint dysfunction caused by degenerative arthritis and related diseases. [0003] Currently, the clinically used diacetyl rhein preparations are mainly capsules. Diacetyl rhein itself is difficult to dissolve in water and alcohol, and the Chinese patent "Pharmaceutical Composition for Oral Administration (ZL Patent No. 9719084.9)" discloses mixing diacety...

Claims

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Application Information

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IPC IPC(8): A61K31/192A61K9/20A61K47/38A61P29/00A61P19/02A61J3/06
Inventor 金幸汤磊袁文艳王琰
Owner 上海慈瑞医药科技股份有限公司
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