Anisodine hydrobromide drop pill and preparing method thereof

A technology of anisodine hydrobromide and dropping pills is applied in the directions of pill delivery, antidote, antipyretic and the like, and can solve the problems affecting the therapeutic effect of anisodine hydrobromide and the disintegration time of anisodine hydrobromide tablets. It is easy to carry and take, has good compliance, and reduces the amount of excipients.

Inactive Publication Date: 2004-09-15
HONGYI SCI & TECH CO LTD NANCHANG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Anisodine hydrobromide tablets take a long time to disintegrate, have poor absorption, low bioavailability, and a large proportion of excipients. Children, the elderly, bedridden patients, and patients with dysphagia are inconvenient to take and have poor compliance, which affects the quality of anisodine hydrobromide. The role of alkali therapy

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0021] prescription:

[0022] Anisodine Hydrobromide 2g

[0023] Macrogol 6000 18g

[0024] Makes 1000 capsules

[0025] Preparation method: Take anisodine hydrobromide fine powder that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten polyethylene glycol 6000 matrix, stir well, use simethicone as a coolant, make pellets by drop method, and dry , that is.

example 2

[0027] prescription:

[0028] Anisodine Hydrobromide 2g

[0029] Macrogol 4000 18g

[0030] Makes 1000 capsules

[0031] Preparation method: Take anisodine hydrobromide fine powder that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten polyethylene glycol 4000 matrix, stir well, use simethicone as a coolant, make pellets by drop method, and dry , that is.

example 3

[0033] prescription:

[0034] Anisodine Hydrobromide 2g

[0035] Polyethylene glycol 6000 8g

[0036] Macrogol 4000 10g

[0037] Makes 1000 capsules

[0038] Preparation method: Take the anisodine hydrobromide fine powder that has been ultrafinely pulverized and passed through a 200 mesh sieve, add it to the molten polyethylene glycol 4000 and polyethylene glycol 6000 mixed matrix, stir well, and use simethicone oil as the coolant , drop into legal pills, dry, and get it.

[0039] 4. Example 4

[0040] prescription:

[0041] Anisodine Hydrobromide 2g

[0042] Glyceryl monostearate 18g

[0043] Makes 1000 capsules

[0044] Preparation method: take the anisodine hydrobromide fine powder that has been ultrafinely pulverized and passed through a 200 mesh sieve, add it to the molten glyceryl monostearate matrix, mix well, use ice water as a coolant, make pellets by dropping, dry, Instantly. ...

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PUM

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Abstract

The present invention utilizes ultramicropulverization and dripping pill preparation production process to make aniosidine hydrobromide dripping pills, and can attain the goal of raising disintegration and dissolution speed, quickly obtaining therapeutic effect, raising stability of medicine, reducing dose of auxiliary material, reducing production cost and convenient administration. Said pill not noly can be sucket, but also can be swallowed, and its compliance is good.

Description

technical field [0001] The invention relates to a pharmaceutical preparation and a preparation method thereof, in particular to anisodine hydrobromide dripping pills and a preparation method thereof. Background technique [0002] Anisodine Hydromide (Anisodine Hydromide) has obvious central anticholinergic effect, it competes with acetylcholine at the M choline receptor site, prevents the combination of acetylcholine and M choline receptor, thereby blocking the transmission of nerve impulses and achieving interference Physiological functions resulting from cholinergic neurotransmission. Can relieve vasospasm, improve microcirculation, anti-tremor, antispasmodic, antiasthma, inhibit glandular secretion, mydriasis and resist organophosphate pesticide poisoning. The intensity of action is weaker than that of atropine, but the toxicity is small. Only tablets are currently on the market, which are clinically used for the treatment of migraine, vascular headache, retinal vasospa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/46A61P25/00A61P25/06A61P29/00A61P39/02
Inventor 钱进许军彭红李平朱丹刘孝乐
Owner HONGYI SCI & TECH CO LTD NANCHANG
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