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Dripping pills of nefopam hydrochloride and its preparation method

A technology of nefopam hydrochloride and nefopam hydrochloride is applied in the field of nefopam hydrochloride dropping pills and preparation thereof, and can solve the problems of affecting the therapeutic effect of nefopam hydrochloride, large proportion of excipients, long tablet disintegration time, and the like, To achieve the effect of convenience in carrying and taking, reducing the amount of excipients, and small pill size

Inactive Publication Date: 2005-01-26
HONGYI SCI & TECH CO LTD NANCHANG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Nefopam hydrochloride has a slightly bitter taste and is slightly soluble in water. The tablet disintegrates for a long time, has poor absorption, low bioavailability, and a large proportion of excipients. It is inconvenient for children, the elderly, bedridden patients and patients with dysphagia to take it. Poor resistance, which affects the therapeutic effect of Nefopam hydrochloride

Method used

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  • Dripping pills of nefopam hydrochloride and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0023] prescription:

[0024] Nefopam Hydrochloride 5g

[0025] Macrogol 6000 15g

[0026] Makes 1000 capsules

[0027] Preparation method: Take nefopam hydrochloride fine powder that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten polyethylene glycol 6000 matrix, stir well, use simethicone as a coolant, make pellets by dropping, dry, and have to.

example 2

[0029] prescription:

[0030] Nefopam Hydrochloride 5g

[0031] Macrogol 4000 15g

[0032] Makes 1000 capsules

[0033] Preparation method: Take nefopam hydrochloride fine powder that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten polyethylene glycol 4000 matrix, stir well, use simethicone as a coolant, make pellets by dropping, dry, and have to.

example 3

[0035] prescription:

[0036] Nefopam Hydrochloride 5g

[0037] Macrogol 6000 10g

[0038] Macrogol 4000 5g

[0039] Makes 1000 capsules

[0040] Preparation method: Take nefopam hydrochloride fine powder that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten mixed matrix of polyethylene glycol 4000 and polyethylene glycol 6000, stir well, use simethicone as coolant, drop The preparation method is to make pills, dry them, and obtain them.

[0041] 4. Example 4

[0042] prescription:

[0043] Nefopam Hydrochloride 5g

[0044] Glyceryl monostearate 15g

[0045] Makes 1000 capsules

[0046] Preparation method: Take nefopam hydrochloride fine powder that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten glyceryl monostearate matrix, mix well, use ice water as a coolant, make pills by drop method, and dry to obtain .

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PUM

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Abstract

The invention relates to a Nefopam Hydrochloride drop pill prepared by utilizing ultramicro disintegration and drop pill manufacturing process, which has the advantages of improving collapse and dissolving speed, quick effect, increased medicament stability, reduced adjuvant consumption, lowered production costs, and easiness in carrying and use. It has good compliance, thus is especially suitable for children, the elderly, bedridden patients and dysphagia patients.

Description

technical field [0001] The invention relates to a pharmaceutical preparation and a preparation method thereof, in particular to Nefopam hydrochloride dropping pills and a preparation method thereof. Background technique [0002] Nefopam hydrochloride is a new type of non-narcotic analgesic with mild antipyretic and muscle relaxant effects. The chemical structure belongs to cyclized o-methyldiphenhydramine, so it does not have the characteristics of non-steroidal anti-inflammatory drugs, nor is it an opioid receptor agonist. Effective for moderate and severe pain, intramuscular injection of Nefopam hydrochloride 20 mg is equivalent to 12 mg of morphine. It has a mild effect on respiratory depression. No inhibitory effect on the circulatory system. No tolerance and dependence. [0003] Nefopam hydrochloride is rapidly absorbed after oral administration, T max 1-3 hours, the first pass effect is obvious. T 1 / 2 For 4-8 hours, the plasma protein binding rate is 71% to 76%....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/553A61P1/04A61P25/04A61P29/00
Inventor 钱进许军彭红李平朱丹刘孝乐
Owner HONGYI SCI & TECH CO LTD NANCHANG
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