Slow released diacetyl rheinic acid prepn and its prepn process

A technology of diacetylrhein and slow-release preparations, which is applied in anti-inflammatory agents, pharmaceutical formulas, non-central analgesics, etc., can solve the problems of patient inconvenience, and achieve the effects of long shelf life, low cost, and high dissolution rate

Inactive Publication Date: 2007-08-22
上海慈瑞医药科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Taking medicine more times will bring a lot of inconvenience to patients

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Preparation of Diacetylrhein Sustained-release Tablets

[0026] Prescription: Diacetylrhein 80g

[0027] Starch 18g

[0028] Lactose 40g

[0029] CC-Na 1.5g

[0030] PVP 0.3g

[0031] Magnesium Stearate 1g

[0032]

[0033] Hypromellose 90g

[0034] Makes 1000 pieces

[0035] Process:

[0036] Grind diacetylrhein, starch, lactose, CC-Na and hydroxypropyl methylcellulose respectively, and pass through an 80-mesh sieve.

[0037] Take 10g of diacetylrhein, 18g of starch, 40g of lactose, and 1.5g of CC-Na, mix well, and make a solution with 0.3g of PVP and 80% ethanol to make a soft material, granulate with a 20-mesh sieve, and put it into a dryer Dry at 60°C, sieve through a 18-mesh sieve, add 0.2g magnesium stearate and mix well to obtain immediate-release granules;

[0038] Take 70g of diacetylrhein and 90g of hydroxypropyl methylcellulose, mix well, use 80% ethanol to make a soft material, granulate wi...

Embodiment 2

[0047] Preparation of Diacetylrhein Sustained Release Capsules

[0048] Ball core prescription: diacetyl rhein 80g

[0049] Low-substituted hydroxypropyl cellulose 40g

[0050] Mannitol 80g

[0051] Sodium carboxymethyl starch 30g

[0052]

[0053] Made into 1000 capsules (capsules)

[0054] Coating prescription: ethyl cellulose 20%; polyethylene glycol 10008%; triethyl citrate 0.08%

[0055] Process: Grinding diacetyl rhein, low-substituted hydroxypropyl cellulose, mannitol and sodium carboxymethyl starch to a fineness of 80 meshes;

[0056] Take 80g of diacetyl rhein, 40g of low-substituted hydroxypropyl cellulose, 80g of mannitol, and 30g of sodium carboxymethyl starch, mix them evenly, put them into pellets with a coating granulator, and wait until the pellets grow to a size of 18-22 mesh, take them out , placed in a dryer and dried at a temperature of 55°C;

[0057] The concentration of ethyl cellulose i...

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Abstract

The present invention is slow released diacetyl rheinic acid preparation and its preparation process. The slow released diacetyl rheinic acid preparation, which may be granule, tablet or capsule, is prepared with diacetyl rheinic acid as main material and other supplementary material. The slow released diacetyl rheinic acid preparation of the present invention has excellent slow releasing effect and simple preparation process.

Description

technical field [0001] The invention relates to a diacetylrhein sustained-release preparation and a preparation method thereof, which are used for treating symptoms such as pain and joint dysfunction caused by degenerative arthritis and related diseases, and belong to the technical field of pharmacy. Background technique [0002] Diacetylrhein, chemical name 4,5-diacetyl-9,10-dihydro-9,10-dioxo-2-anthracene carboxylic acid, also known as Diacerein (Diacerein), for osteoarthritis IL-1 Inhibitor, can induce cartilage production, has analgesic, anti-inflammatory and antipyretic effects. It is clinically used to treat symptoms such as pain and joint dysfunction caused by degenerative arthritis and related diseases. [0003] The currently clinically used diacetyl rhein preparations are mainly ordinary tablets and ordinary capsules. The drug release rate of these two common capsules belongs to normal release, in order to ensure the effective blood drug concentration, it needs to...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/192A61K9/22A61K9/52A61K47/38A61P19/02A61P29/00
Inventor 金幸汤磊袁文艳王琰
Owner 上海慈瑞医药科技股份有限公司
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