Chitosan oligosaccharide drop pill and method for preparing same

A technology for chitosan and sugar drop pills, which is applied in the directions of pharmaceutical formulations, medical preparations with inactive ingredients, and medical preparations containing active ingredients, etc., can solve the problem of complicated operations in the preparation process of microspheres or nanoparticles and unfavorable product production. and development, poor bioavailability and other issues, to achieve the effect of improving bioavailability, significant technical advantages, and low cost

Active Publication Date: 2018-09-21
GUANGDONG PHARMA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, chitosan is insoluble in water, has poor bioavailability in the body, and is difficult to fully exert its biological activity function. Therefore, it is still urgent to find a reasonable dosage form to improve the solubility of chitosan
[0005] Chinese patent CN101978954A discloses a preparation method and application thereof of chitosan microspheres, Pan, H. etc. (Pan, H., Yang, Q., Huang, G., Ding, C., Cao, P., Huang, L., Xiao, T., Guo, J., Su, Z. Hypolipidemic effects of chitosan and its derivatives in hyperlipidemicrats induced by a high-fat diet [J]. Food Nutr Res. 2016, 60, 31137) Preparation A chitosan microsphere, Zhang, H. et al (Zhang, H., Tao, Y., Guo, J., Hu, Y., Su, Z. Hypolipidemic effects of chitosan nanoparticles in hyperlipidemia rats induced by high fat diet[J].2011,11(4),457-461) prepared a kind of chitosan nanoparticles, but the preparation process of microspheres or nanoparticles is complicated, which is not conducive to the production and development of products
[0006] Chinese patent CN101298502 discloses a method for increasing the water solubility of chitosan, chitosan is mixed with polyethylene glycol 4000-polyethylene glycol 6000 to prepare chitosan solid dispersion, but the patent chitosan and matrix The ratio is 1:10, the amount of substrate is large, the drug loading is low, and the dosage is large

Method used

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  • Chitosan oligosaccharide drop pill and method for preparing same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Take by weighing 5g of chitosan and 30g of matrix (polyethylene glycol 400023g, polyethylene glycol 80007g) according to the formula ratio.

[0031] Heat and melt the matrix in a water bath; stir and add chitosan while heating to melt, and fully mix the matrix and chitosan; Drop into liquid paraffin with a drop distance of 18cm and a drop rate of 25 drops / min, condense at 15°C, solidify to form drop pills, take them out and dry them to obtain chitosan drop pills.

Embodiment 2

[0033] Weigh 5g of chitosan and 20g of matrix (polyethylene glycol 600012.5g, poloxamer 7.5g) according to the formula ratio.

[0034] Heat and melt the matrix in a water bath; stir and add chitosan while heating to melt, and fully mix the matrix and chitosan; Drop into liquid paraffin with a drop distance of 16cm and a drop rate of 30 drops / min, condense at 20°C, solidify to form drop pills, take them out and dry them to obtain chitosan drop pills.

Embodiment 3

[0036] Take by weighing 5g of chitosan and 20g of matrix (polyethylene glycol 800015g, sodium carboxymethylcellulose 5g) according to the formula ratio.

[0037] Heat and melt the matrix in a water bath; stir and add chitosan while heating to melt, and fully mix the matrix and chitosan; Drop into liquid paraffin at a drop distance of 20 cm at a rate of 28 drops / min, condense at 10°C, solidify to form drop pills, take them out and dry to obtain chitosan drop pills.

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Abstract

The invention relates to the technical field of medicines, in particular to a chitosan oligosaccharide drop pill and a method for preparing the same. The chitosan oligosaccharide drop pill is preparedfrom chitosan oligosaccharides and drop pill matrixes. A weight ratio of the chitosan oligosaccharides to the drop pill matrixes is 1:1-1:6. The chitosan oligosaccharides and the drop pill matrixes are components in the chitosan oligosaccharide drop pill. The chitosan oligosaccharide drop pill and the method have the advantages that the prescription for the chitosan oligosaccharide drop pill which is a drop pill preparation is determined by means of scientific screening tests; the dissolution rate of the chitosan oligosaccharides can be obviously increased, the bioavailability of the chitosanoligosaccharides can be obviously improved, and accordingly the chitosan oligosaccharide drop pill and the method have obvious technical superiority; processes for preparing the chitosan oligosaccharide drop pill are simple, and the chitosan oligosaccharide drop pill and the method are low in cost and have excellent application prospects.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to a chitosan dripping pill and a preparation method thereof. Background technique [0002] Chitosan (chitosan, CTSH) is a natural macromolecular alkaline polysaccharide second only to cellulose, composed of glucose (β copolymer (1–4) and 2-amino-2-deoxy-D-glucose) and N-acetylglucosamine (2-acetamido-2-deoxy-d-glucose). In 1859, chitosan was first discovered and discussed by Rouget as a deacetylated chitin derivative. [0003] Chitosan is safe, non-toxic and has a variety of biologically active functions. It is widely used in anti-inflammation, anti-oxidation, lowering blood lipids, improving insulin resistance, enhancing immunity, etc. Research results have found that chitosan can significantly inhibit the digestive system. The absorption of TC and TG in the middle, so as to prevent the accumulation of TC and fatty acids in the body, and promote excretion out of the body, so a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K31/722A61K47/10A61P3/04
CPCA61K9/1641A61K31/722A61P3/04
Inventor 苏政权
Owner GUANGDONG PHARMA UNIV
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