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Berberine hydrochloride medicinal composition and preparation method thereof

A technology of berberine hydrochloride and its composition, which is applied in the field of berberine hydrochloride pharmaceutical composition and its preparation, can solve the problems of poor bioavailability and slow onset of action, and achieve rapid disintegration and dissolution, high drug efficacy, and solution insoluble effect

Inactive Publication Date: 2012-03-14
JILIN AODONG GROUP DALIAN PHARMACEUTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, its common dosage forms are slightly soluble in water, have poor bioavailability, and slow onset of action.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0018] A kind of berberine hydrochloride pharmaceutical composition and preparation method thereof of the present invention will be illustrated below in conjunction with the examples.

[0019] A berberine hydrochloride pharmaceutical composition, with berberine hydrochloride as an active ingredient, excipients: fillers are mannitol, dextrin, lactose; disintegrants are sodium hydroxymethyl starch, low-substituted hydroxypropyl cellulose; The flavoring agent is sucrose and citric acid; the lubricant is zinc stearate and polyethylene glycol; the weight ratio is 36:50:12:1.6:0.4.

[0020] A method for preparing the above-mentioned berberine hydrochloride pharmaceutical composition, comprising the following steps:

[0021] (1) Dissolve and weigh berberine hydrochloride, filler mannitol, dextrin, lactose; disintegrant sodium hydroxymethyl starch, low-substituted hydroxypropyl cellulose; flavoring agent sucrose, citric acid; lubricant stearic acid Zinc and polyethylene glycol are mi...

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PUM

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Abstract

The invention discloses a berberine hydrochloride medicinal composition and a preparation method thereof, which are used for increasing the dissolution rate of berberine hydrochloride in water and enhance the in-vivo absorption of berberine hydrochloride. According to the specific technical scheme, berberine hydrochloride serves as a medicinal active ingredient of the composition; and a filling agent, a disintegrating agent, a flavoring agent and a lubricating agent in the weight ratio (1-50):(25-60):(3-15):(1.5-3):(0.4-1.2) serve as auxiliary materials. The method for preparing the berberine hydrochloride medicinal composition comprises the following steps of: (1) dissolving; (2) drying; (3) screening; and (4) tableting. The berberine hydrochloride medicinal composition prepared with the method has high disintegrating and dissolving speeds and a good medicament effect, and the problems of low solubility and unstable absorption of berberine hydrochloride are solved. The berberine hydrochloride medicinal composition is effective to enteral infection caused by dysentery bacillus and colon bacillus, and is used for treating enteral infection and diarrhea.

Description

technical field [0001] The invention belongs to the field of new medicine technology, in particular to a berberine hydrochloride pharmaceutical composition and a preparation method thereof. Background technique [0002] Berberine hydrochloride, also known as berberine, is composed of alkaloids extracted from Coptis chinensis, Sancizhen, Cortex Phellodendron and other berberine plants. It is a main alkaloid in the rhizome of Coptidis Rhizome of Ranunculaceae, and it can also be synthesized artificially. It has a wide antibacterial spectrum, and has antibacterial effects on a variety of Gram-positive and negative bacteria in vitro, including hemolytic streptococci, Staphylococcus aureus, and Vibrio cholerae. Meningococcus, Shigella dysenteriae, typhoid bacillus, diphtheria bacillus, etc. have a strong inhibitory effect, inhibiting bacteria at low concentrations and sterilizing at high concentrations. It also has a certain inhibitory effect on influenza virus, amoeba, leptosp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4375A61K9/20A61P31/04A61P1/00
CPCY02A50/30
Inventor 刘德胜
Owner JILIN AODONG GROUP DALIAN PHARMACEUTICAL CO LTD
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