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Quinoline coridalis B drops and preparation thereof

A technology of tetrahydropalmatine and sulfuric acid, applied in pill delivery, nervous system diseases, non-central analgesics, etc., can solve problems affecting the therapeutic effect of tetrahydropalmatine sulfate, large proportion of excipients, long disintegration time of tablets, etc. , to achieve the effect of convenient carrying and taking, reduced dosage of excipients, and small pill size

Inactive Publication Date: 2004-04-21
HONGYI SCI & TECH CO LTD NANCHANG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Tetrahydropalmatine sulfate is odorless; tastes slightly bitter; easily turns yellow when exposed to light and heat; dissolves in water, the tablet disintegrates for a long time, and the proportion of excipients is large, which is inconvenient for children, the elderly, bedridden patients and patients with dysphagia. Poor compliance, affecting the therapeutic effect of tetrahydropalmatine sulfate

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0021] prescription:

[0022] Tetrahydropalmatine Sulfate 5g

[0023] Macrogol 6000 15g

[0024] Makes 1000 capsules

[0025] Preparation method: Add tetrahydropalmatine sulfate fine powder that has been superfinely pulverized and passed through a 200-mesh sieve into molten polyethylene glycol 6000 matrix, stir evenly, use simethicone oil as coolant, make pellets by drop method, and dry. have to.

example 2

[0027] prescription:

[0028] Tetrahydropalmatine Sulfate 5g

[0029] Macrogol 4000 15g

[0030] Makes 1000 capsules

[0031] Preparation method: take the ultrafine pulverized tetrahydropalmatine sulfate powder and pass through a 200-mesh sieve, add it to the molten polyethylene glycol 4000 matrix, stir well, use simethicone as a coolant, make pellets by drop method, and dry. have to.

example 3

[0033] prescription:

[0034] Tetrahydropalmatine Sulfate 5g

[0035] Macrogol 6000 5g

[0036] Macrogol 4000 10g

[0037] Makes 1000 capsules

[0038] Preparation method: take the tetrahydropalmatine sulfate fine powder that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten polyethylene glycol 4000 and polyethylene glycol 6000 mixed matrix, stir well, use simethicone as the coolant, drop The preparation method is to make pills, dry them, and obtain them.

[0039] 4. Example 4

[0040] prescription:

[0041] Tetrahydropalmatine Sulfate 5g

[0042] Glyceryl monostearate 15g

[0043] Makes 1000 capsules

[0044] Preparation method: Take the ultrafine pulverized tetrahydropalmatine sulfate powder and pass through a 200-mesh sieve, add it to the melted glyceryl monostearate base, mix well, use ice water as the coolant, make pellets by drop method, and dry to obtain .

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PUM

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Abstract

A dripping pile of corydalis B hydrochloride is prepared through superfine pulverizing and the conventional steps for preparing dripping pills. Its advantages are high disintegrating and dissolving speed, quickly taking its effect and low cost.

Description

technical field [0001] The invention relates to a medicine preparation and a preparation method thereof, in particular to tetrahydropalmatine sulfate dripping pills and a preparation method thereof. Background technique [0002] Tetrahydropalmatine sulfate has analgesic, sedative, hypnotic and stable effects. The analgesic effect is not as good as pethidine, but stronger than general antipyretic analgesics. The analgesic effect occurs 10-30 minutes after taking it and lasts for 2-5 hours. It has a good effect on the dull pain of gastrointestinal and hepatobiliary system diseases, and has a poor analgesic effect on trauma, postoperative pain or advanced cancer. The therapeutic dose is non-addictive. The oral preparations currently on the market are only Tetrahydropalmatine Sulfate Tablets, which are clinically used for visceral pain and menstrual pain caused by digestive system diseases, postpartum abdominal pain, headache and insomnia. [0003] Tetrahydropalmatine sulfat...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/4745A61P25/20A61P29/00
Inventor 钱进许军彭红李平朱丹刘孝乐
Owner HONGYI SCI & TECH CO LTD NANCHANG
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