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Dripping pills of meloxicam and its preparation

A technology of meloxicam and dripping pills, which is applied in the field of pharmaceutical preparations and its preparation, can solve the problems affecting the therapeutic effect of meloxicam, long disintegration time of meloxicam tablets, and large proportion of excipients, and achieves It is convenient to carry and take, good compliance, and the effect of reducing the amount of auxiliary materials

Inactive Publication Date: 2004-11-17
HONGYI SCI & TECH CO LTD NANCHANG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Meloxicam tablets take a long time to disintegrate, have poor absorption, low bioavailability, and a large proportion of excipients. Children, the elderly, bedridden patients, and patients with dysphagia are inconvenient to take and have poor compliance, which affects the therapeutic effect of meloxicam. to play

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0022] prescription:

[0023] Meloxicam 7.5g

[0024] Macrogol 6000 12g

[0025] Makes 1000 capsules

[0026] Preparation method: Take the meloxicam fine powder that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten polyethylene glycol 6000 matrix, stir well, use simethicone oil as a coolant, make pellets by drop method, and dry. have to.

example 2

[0028] prescription:

[0029] Meloxicam 7.5g

[0030] Macrogol 4000 12g

[0031] Makes 1000 capsules

[0032] Preparation method: Take the meloxicam fine powder that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten polyethylene glycol 4000 matrix, stir well, use simethicone as a coolant, make pellets by drop method, and dry. have to.

example 3

[0034] prescription:

[0035] Meloxicam 7.5g

[0036] Macrogol 6000 2g

[0037] Macrogol 4000 10g

[0038] Makes 1000 capsules

[0039] Preparation method: Take meloxicam fine powder that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten polyethylene glycol 4000 and polyethylene glycol 6000 mixed matrix, stir well, use simethicone as a coolant, drop The preparation method is to make pills, dry them, and obtain them.

[0040] 4. Example 4

[0041] prescription:

[0042] Meloxicam 7.5g

[0043] Glyceryl monostearate 12g

[0044] Makes 1000 capsules

[0045] Preparation method: Take meloxicam fine powder that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten glyceryl monostearate base, mix well, use ice water as a coolant, make pellets by dropping, dry, and obtain .

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Abstract

The invention relates to a meloxicam drop pill prepared by utilizing ultramicro disintegration and drop pill manufacturing process, which has the advantages of improving collapse and dissolving speed, quick effect, increased medicament stability, reduced adjuvant consumption, lowered production costs, and easiness in carrying and use. It has good compliance, thus is especially suitable for children, the elderly, bedridden patients and dysphagia patients.

Description

technical field [0001] The invention relates to a medicine preparation and a preparation method thereof, in particular to meloxicam dripping pills and a preparation method thereof. Background technique [0002] Meloxicam is an enolic acid non-steroidal anti-inflammatory drug with anti-inflammatory, analgesic and antipyretic effects. Selectively inhibits cyclooxygenase-2 (Cox-2), and has a weak inhibitory effect on cyclooxygenase-1, so there are few adverse reactions such as the digestive system. [0003] Oral and rectal administration of meloxicam is well absorbed. After oral absorption, more than 99% of the drug in plasma is bound to plasma protein, and the half-life is about 20 hours. About 50% of the metabolites are excreted in urine, and the rest are excreted in feces. When hepatic insufficiency or mild or moderate renal insufficiency, the pharmacokinetic parameters have no significant changes. For the symptomatic treatment of rheumatoid arthritis and painful arthriti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/5415A61P29/00
Inventor 钱进许军彭红李平朱丹刘孝乐
Owner HONGYI SCI & TECH CO LTD NANCHANG
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