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Dripping pills of methoxsalen and its preparation method

A technology of methoxsalen and dropping pills, which is applied in the directions of pill delivery, skin diseases, drug combination, etc., can solve the problems of affecting the therapeutic effect of methoxsalen, low dissolution rate and dissolution rate, and large proportion of excipient dosage, etc. Ease of carrying and administration, improved dissolution rate and dissolution rate, and reduced excipient dosage

Inactive Publication Date: 2005-04-06
HONGYI SCI & TECH CO LTD NANCHANG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Methoxsalen is insoluble in water, and its tablet disintegrates for a long time, with low dissolution rate and dissolution rate, poor absorption, low bioavailability, and a large proportion of excipients, which is inconvenient for children, the elderly, bedridden patients and patients with dysphagia. , poor compliance, affecting the therapeutic effect of methoxsalen

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0051] prescription:

[0052] Methoxsalen 5g

[0053] Polyethylene glycol 6000 15g

[0054] Makes 1000 capsules

[0055] Preparation method: Take the methoxsalen fine powder that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten polyethylene glycol 6000 matrix, stir well, use simethicone oil as a coolant, make pellets by drop method, and dry. have to.

example 2

[0057] prescription:

[0058] Methoxsalen 5g

[0059] Macrogol 4000 15g

[0060] Makes 1000 capsules

[0061] Preparation method: Take the methoxsalen fine powder that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten polyethylene glycol 4000 matrix, stir well, use simethicone as a coolant, make pellets by drop method, and dry. have to.

example 3

[0063] prescription:

[0064] Methoxsalen 5g

[0065] Macrogol 6000 5g

[0066] Macrogol 4000 10g

[0067] Makes 1000 capsules

[0068] Preparation method: Take the methoxsalen fine powder that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten polyethylene glycol 4000 and polyethylene glycol 6000 mixed matrix, stir well, use simethicone as the coolant, drop The preparation method is to make pills, dry them, and obtain them.

[0069] 4. Example 4

[0070] prescription:

[0071] Methoxsalen 5g

[0072] Glyceryl monostearate 15g

[0073] Makes 1000 capsules

[0074] Preparation method: Take the methoxsalen fine powder that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten glyceryl monostearate base, mix well, use ice water as the coolant, make pellets by drop method, and dry to obtain .

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PUM

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Abstract

The invention uses super micro shattering and drop pills producing the technology to produce fenfluramine drop pills, reaching the purposes such as increasing speed, and dissolution of disintegration, increasing the medicine stability, reducing the dose of auxiliary materials and decreasing cost, with rapid effect and convenient use. It can be buccal as well as deglutition, has remarkable conformity, and is especially suitable for children, older man, sicker in bed or with difficulty of swallowing.

Description

technical field [0001] The invention relates to a medicine preparation and a preparation method thereof, in particular to methoxsalen dripping pills and a preparation method thereof. Background technique [0002] Methoxsalen is a photosensitizer, and 8-MOP combined with epidermal cells can be activated by long-wave ultraviolet rays with a wavelength of 320-400nm, and the maximum wavelength of action is 365nm. Under the action of long-wave ultraviolet rays, 8-MOP reacts photochemically with thymine on the DNA double helix of epidermal cells to form a photoadduct, resulting in a phototoxic reaction, which inhibits DNA synthesis and mitotic division of epidermal cells, and renews epidermal cells. The speed is slowed down, thus playing a therapeutic role in psoriasis. As a result of photosensitivity, the activity of tyrosinase in melanocytes increases, which promotes the formation of melanin; it promotes the movement of melanocytes in hair follicles to the epidermis, resulting ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/366A61P17/06
Inventor 钱进许军彭红李平朱丹刘孝乐
Owner HONGYI SCI & TECH CO LTD NANCHANG
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