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Propranolol hydrochloride drop pills and its preparation method

A technology of propranolol hydrochloride dropping pills and propranolol hydrochloride, applied in pill delivery, cardiovascular system diseases, drug combination, etc., can solve the problem of low dissolution rate and dissolution rate affecting the therapeutic effect of propranolol hydrochloride , high proportion of excipients, etc., to achieve the effect of convenient carrying and taking, improved dissolution rate and dissolution rate, and reduced amount of excipients

Inactive Publication Date: 2005-04-06
HONGYI SCI & TECH CO LTD NANCHANG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Propranolol hydrochloride tastes slightly sweet and bitter, and dissolves in water, but its tablet disintegration time is long, the dissolution rate and dissolution rate are low, the absorption is poor, the bioavailability is low, and the proportion of excipients is large. Children, the elderly, bedridden It is inconvenient for patients and patients with dysphagia to take it, and the compliance is poor, which affects the therapeutic effect of propranolol hydrochloride

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0055] prescription:

[0056] Propranolol Hydrochloride 5g

[0057] Macrogol 6000 15g

[0058] Makes 1000 capsules

[0059] Preparation method: Take propranolol hydrochloride fine powder that has been superfinely pulverized and passed through a 200-mesh sieve, add it to the molten polyethylene glycol 6000 matrix, stir well, use simethicone as coolant, make pellets by drop method, dry, Instantly.

example 2

[0061] prescription:

[0062] Propranolol Hydrochloride 5g

[0063] Macrogol 4000 15g

[0064] Makes 1000 capsules

[0065] Preparation method: Take propranolol hydrochloride fine powder that has been superfinely pulverized and passed through a 200-mesh sieve, add it to the molten polyethylene glycol 4000 matrix, stir well, use simethicone as a coolant, make pellets by drop method, dry, Instantly.

example 3

[0067] prescription:

[0068] Propranolol Hydrochloride 5g

[0069] Macrogol 6000 5g

[0070] Macrogol 4000 10g

[0071] Makes 1000 capsules

[0072] Preparation method: Take propranolol hydrochloride fine powder that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten polyethylene glycol 4000 and polyethylene glycol 6000 mixed matrix, stir well, use simethicone as a coolant, Drop system into legal pills, dry, and get it.

[0073] 4. Example 4

[0074] prescription:

[0075] Propranolol Hydrochloride 5g

[0076] Glyceryl monostearate 15g

[0077] Makes 1000 capsules

[0078] Preparation method: Take propranolol hydrochloride fine powder that has been superfinely pulverized and passed through a 200-mesh sieve, add it to the molten glyceryl monostearate matrix, mix well, use ice water as a coolant, make pellets by dropping, dry, and have to.

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PUM

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Abstract

The invention uses super micro shattering and propranolol drop pills producing the technology to produce fenfluramine drop pills, reaching the purposes such as increasing speed, and dissolution of disintegration, increasing the medicine stability, reducing the dose of auxiliary materials and decreasing cost, with rapid effect and convenient use. It can be buccal as well as deglutition, has remarkable conformity, and is especially suitable for children, older man, sicker in bed or with difficulty of swallowing.

Description

technical field [0001] The invention relates to a medicine preparation and a preparation method thereof, in particular to propranolol hydrochloride dropping pills and a preparation method thereof. Background technique [0002] Propranolol hydrochloride is a nonselective competitive inhibitor of adrenergic beta receptor blockers, blocking beta on the heart 1 , β 2 Receptors, antagonize sympathetic nerve excitation and catecholamine, reduce heart contraction force and contraction speed, and at the same time inhibit vascular smooth muscle contraction, reduce myocardial oxygen consumption, restore the balance of oxygen supply and demand in ischemic myocardium at a low level, and can be used for treatment Angina. [0003] Propranolol hydrochloride can inhibit the adrenergic excitation of the cardiac pacemaker potential, and is used to treat arrhythmia. in the treatment of hypertension. [0004] Propranolol hydrochloride can competitively antagonize the effects of isoprotereno...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/138A61P9/10A61P9/12
Inventor 钱进许军彭红李平朱丹刘孝乐
Owner HONGYI SCI & TECH CO LTD NANCHANG
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