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Aparkan drops and their preparation

A technology of trihexyphenidyl hydrochloride and dihexyphenidyl hydrochloride, which is applied in the fields of pill delivery, nervous system diseases, and active ingredients of heterocyclic compounds, etc. It can solve the problem of affecting the therapeutic effect of benzhexol hydrochloride, long disintegration time of tablets, and the proportion of excipients Large and other problems, to achieve the effect of convenient carrying and taking, small pill volume, and reduced amount of excipients

Inactive Publication Date: 2005-02-23
HONGYI SCI & TECH CO LTD NANCHANG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Trihexyphenidyl hydrochloride has a slightly bitter taste and a tingling numbness afterward. It is slightly soluble in water. Its tablet disintegrates for a long time, has poor absorption, low bioavailability, and a large proportion of excipients. Children, the elderly, bedridden patients and those who swallow Difficult patients are inconvenient to take and have poor compliance, which affects the therapeutic effect of trihexyphenidyl hydrochloride

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0022] prescription:

[0023] Trihexyphenidyl Hydrochloride 2g

[0024] Macrogol 6000 18g

[0025] Makes 1000 capsules

[0026] Preparation method: Take trihexyphenidyl hydrochloride fine powder that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten polyethylene glycol 6000 matrix, stir well, use simethicone oil as coolant, make pellets by drop method, dry, that is have to.

example 2

[0028] prescription:

[0029] Trihexyphenidyl Hydrochloride 2g

[0030] Macrogol 4000 18g

[0031] Makes 1000 capsules

[0032] Preparation method: Take trihexyphenidyl hydrochloride fine powder that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten polyethylene glycol 4000 matrix, stir well, use simethicone oil as a coolant, make pellets by drop method, and dry. have to.

example 3

[0034] prescription:

[0035] Trihexyphenidyl Hydrochloride 2g

[0036] Macrogol 6000 15g

[0037] Macrogol 4000 5g

[0038] Makes 1000 capsules

[0039] Preparation method: Take trihexyphenidyl hydrochloride powder that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten mixed matrix of polyethylene glycol 4000 and polyethylene glycol 6000, stir well, use simethicone as the coolant, drop The preparation method is to make pills, dry them, and obtain them.

[0040] 4. Example 4

[0041] prescription:

[0042] Trihexyphenidyl Hydrochloride 2g

[0043] Glyceryl monostearate 18g

[0044] Makes 1000 capsules

[0045] Preparation method: take trihexyphenidyl hydrochloride fine powder that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten glyceryl monostearate base, mix well, use ice water as a coolant, make pellets by drop method, and dry to obtain .

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PUM

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Abstract

A dripping pill of trihexyphenidyl is prepared by superfine pulverizing and conventional process for preparing dripping pills.

Description

technical field [0001] The invention relates to a pharmaceutical preparation and a preparation method thereof, in particular trihexyphenidyl hydrochloride dropping pills and a preparation method thereof. Background technique [0002] Trihexyphenidyl hydrochloride is a central anticholinergic anti-Parkinson's disease drug, which acts on selectively blocking the cholinergic nerve pathways in the striatum, but has little effect on the periphery, which is beneficial to the recovery of dopamine and The balance of acetylcholine improves the symptoms of Parkinson's disease in patients. [0003] Trihexyphenidyl hydrochloride is absorbed quickly and completely after oral administration, and can pass through the blood-brain barrier. It takes effect within 1 hour of oral administration and lasts for 6-12 hours. 56% of the dosage is excreted with urine, and the excretion is slow when renal insufficiency occurs, it has accumulation effect, and can be secreted from milk. At present, the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/445A61P25/16
Inventor 钱进许军彭红李平朱丹刘孝乐
Owner HONGYI SCI & TECH CO LTD NANCHANG
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