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Berberine or berberine salts drops and their preparation

A technology of berberine salt and berberine, applied in the field of pharmaceutical preparations and preparation thereof, can solve the problems of affecting the therapeutic effect of berberine or berberine salt, low dissolution rate and dissolution rate, large proportion of excipients and the like , to achieve the effects of convenience in carrying and taking, improvement in dissolution rate and dissolution rate, and reduction in dosage

Inactive Publication Date: 2004-04-21
HONGYI SCI & TECH CO LTD NANCHANG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The oral preparations of berberine or berberine salt currently on the market include tablets and capsules, but they have long disintegration time, low dissolution rate and dissolution rate, poor absorption, low bioavailability, and large proportion of excipients. Children, the elderly People, bedridden patients and patients with dysphagia are inconvenient to take and have poor compliance, which affects the therapeutic effect of berberine or berberine salt

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0051] prescription:

[0052] Berberine Hydrochloride 5g

[0053] Macrogol 6000 15g

[0054] Makes 1000 capsules

[0055] Preparation method: take the berberine hydrochloride fine powder that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten polyethylene glycol 6000 matrix, stir well, use simethicone as a coolant, make pellets by dropping, dry, and have to.

example 2

[0057] prescription:

[0058] Berberine Hydrochloride 5g

[0059] Macrogol 4000 15g

[0060] Makes 1000 capsules

[0061] Preparation method: Take the berberine hydrochloride fine powder that has been ultrafinely pulverized and passed through a 200 mesh sieve, add it to the molten polyethylene glycol 4000 matrix, stir well, use simethicone as a coolant, make pellets by dropping, dry, and have to.

example 3

[0063] prescription:

[0064] Berberine Hydrochloride 5g

[0065] Macrogol 6000 5g

[0066] Macrogol 4000 10g

[0067] Makes 1000 capsules

[0068]Preparation method: take the berberine hydrochloride fine powder that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten polyethylene glycol 4000 and polyethylene glycol 6000 matrix, stir well, use simethicone as a coolant, Drop system into legal pills, dry, and get it.

[0069] 4. Example 4

[0070] prescription:

[0071] Berberine Hydrochloride 5g

[0072] Glyceryl monostearate 15g

[0073] Makes 1000 capsules

[0074] Preparation method: take the berberine hydrochloride fine powder that has been ultrafinely pulverized and passed through a 200 mesh sieve, add it to the molten glyceryl monostearate matrix, mix well, use ice water as the coolant, make pills by dropping, dry, and obtain .

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PUM

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Abstract

A dripping pile of berberine or its salts is prepared through superfine pulverizing and the conventional steps for preparing dripping pill. Its advantages are high disintegrating and dissolving speed, quickly taking its effect and low cost.

Description

technical field [0001] The invention relates to a pharmaceutical preparation and a preparation method thereof, in particular to berberine or berberine salts, such as berberine hydrochloride, berberine hydrogen sulfate or berberine tannin drop pills and a preparation method thereof. Background technique [0002] Berberine has a broad antibacterial spectrum, and has inhibitory effects on a variety of Gram-positive and Gram-negative bacteria in vitro, including hemolytic streptococcus, Staphylococcus aureus, Vibrio cholerae, meningococcus, Shigella, and typhoid bacillus , diphtheria bacilli, etc. have a strong inhibitory effect. [0003] In vitro experiments have confirmed that berberine can enhance the phagocytosis of leukocytes and liver reticuloendothelial system. Shigella, hemolytic streptococcus, and Staphylococcus aureus are prone to develop resistance to berberine. It is mainly used clinically for intestinal infections such as gastroenteritis and bacillary dysentery ca...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/4375A61P31/04
Inventor 钱进许军彭红李平刘孝乐
Owner HONGYI SCI & TECH CO LTD NANCHANG
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