Dexlansoprazole sustained-release capsule and preparation method thereof

A technology of dexlansoprazole and sustained-release capsules, applied in the field of dexlansoprazole sustained-release capsules and its preparation, can solve the problems of dexlansoprazole instability, difficulty in development, unstable properties of aqueous solution, etc.

Inactive Publication Date: 2015-04-22
BEIJING RED SUN PHARMA
View PDF4 Cites 13 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, there is a chemical structure of sulfinylbenzimidazole in the structure of dexlansoprazole, which is easily affected by various factors such as light, heavy metal ions, oxidizing and reducing components, etc.
Especial

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Dexlansoprazole sustained-release capsule and preparation method thereof
  • Dexlansoprazole sustained-release capsule and preparation method thereof
  • Dexlansoprazole sustained-release capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Embodiment 1 A kind of dexlansoprazole sustained-release capsule and preparation method thereof

[0030] Dexlansoprazole sustained-release capsules consist of enteric-coated pellets and sustained-release pellets.

[0031] 1. Composition of enteric-coated pellets:

[0032]

[0033] 2. Sustained-release pellets

[0034]

[0035] 3. Preparation process

[0036] Preparation process of enteric-coated pellets: (1) Mix the prescription amount of dexlansoprazole, magnesium carbonate, sucrose, and low-substituted hydroxypropyl cellulose evenly to obtain solid powder, disperse with hydroxypropyl methylcellulose (HPMC E5) A 3% solution of the binder in water was obtained. Fill 200g of blank microcrystalline cellulose pellet cores (28-32 mesh) into a centrifugal coating granulator, and spray with the above-mentioned spray solution under the following conditions: inlet air temperature: 25-30°C, spray the coating solution Rate: 1.0g / min, spray pressure 0.5kg / cm 2 , the obt...

Embodiment 2

[0045] Embodiment 2 A kind of dexlansoprazole sustained-release capsule and preparation method thereof

[0046] Dexlansoprazole sustained-release capsules consist of enteric-coated pellets and sustained-release pellets.

[0047] 1. Composition of enteric-coated pellets:

[0048]

[0049] 2. Sustained-release pellets

[0050]

[0051] 3. Preparation process

[0052] Preparation process of enteric-coated pellets: (1) Mix the prescription amount of dexlansoprazole, magnesium carbonate, sucrose, and low-substituted hydroxypropyl cellulose evenly to obtain solid powder, disperse with hydroxypropyl methylcellulose (HPMC E5) A 3% solution of the binder in water was obtained. Fill 200g of blank microcrystalline cellulose pellet cores (28-32 mesh) into a centrifugal coating granulator, and spray with the above-mentioned spray solution under the following conditions: inlet air temperature: 25-30°C, spray the coating solution Rate: 1.0g / min, spray pressure 0.5kg / cm 2 , the obt...

Embodiment 3

[0061] Embodiment 3 a kind of dexlansoprazole sustained-release capsules and preparation method thereof

[0062] Dexlansoprazole sustained-release capsules consist of enteric-coated pellets and sustained-release pellets.

[0063] 1. Composition of enteric-coated pellets:

[0064]

[0065] 2. Sustained-release pellets

[0066]

[0067] 3. Preparation process

[0068] Preparation process of enteric-coated pellets:

[0069] (1) Mix the prescription amount of dexlansoprazole, magnesium carbonate, sucrose, and low-substituted hydroxypropyl cellulose evenly to obtain solid powder, and disperse hydroxypropyl methylcellulose (HPMC E5) in water to obtain 3% bonding agent solution. Fill 200g of blank microcrystalline cellulose pellet cores (28-32 mesh) into a centrifugal coating granulator, and spray with the above-mentioned spray solution under the following conditions: inlet air temperature: 25-30°C, spray the coating solution Rate: 1.0g / min, spray pressure 0.5kg / cm 2 , th...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to a dexlansoprazole sustained-release capsule and a preparation method thereof. The capsule comprises two dexlansoprazole micropills, wherein the two micropills consist of hollow pill cores, active medicine layers, isolating coating layers and sustained-release coating layers. The dexlansoprazole sustained-release capsule provided by the invention can be released in the intestinal tract in position so as to persistently inhibit acid release.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a sustained-release capsule of dexlansoprazole and a preparation method thereof. Background technique [0002] Gastroesophageal reflux disease is a common and frequently-occurring disease in gastroenterology, and its incidence varies around the world. In Western Europe and North America, the incidence rate of gastroesophageal reflux disease is 10%-20%, in South America it is about 10%, in my country the incidence rate is about 7%-8%. Heartburn is the most prominent symptom of gastroesophageal reflux disease. It is manifested as a burning sensation behind the sternum or under the xiphoid process, often extending upward from the lower part of the sternum, and usually occurs one hour after a meal. It is aggravated when lying down, bending over or when abdominal pressure increases. Sometimes heartburn feels like being scalded in boiling water. Other ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K9/52A61K31/4439A61K47/02A61P1/04
Inventor 林德良
Owner BEIJING RED SUN PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap