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Compound with metformin and repaglinide, preparation method thereof and application thereof

A technology of metformin hydrochloride and compound recipe, applied in the field of medicine, can solve the problems such as no literature report of metformin hydrochloride, and achieve the effects of reducing the number of times of taking, simplifying use, and improving the quality of life

Inactive Publication Date: 2010-09-08
深圳南方盈信制药有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] But after searching, there is no literature report on the compound composition preparation of metformin hydrochloride and repaglinide

Method used

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  • Compound with metformin and repaglinide, preparation method thereof and application thereof
  • Compound with metformin and repaglinide, preparation method thereof and application thereof
  • Compound with metformin and repaglinide, preparation method thereof and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Embodiment 1 sustained-release tablet, sustained-release granule, sustained-release capsule

[0032] prescription

[0033]

[0034] Preparation:

[0035] Particle 1: Pass the main ingredient and auxiliary materials through 80-mesh sieve for later use. Take metformin hydrochloride, repaglinide, ethyl cellulose, HPMC (K4M), microcrystalline cellulose, lactose according to the prescription, after mixing with the method of equal increments, add 8% PVP hydroalcoholic solution, make the material reach " Knead into agglomerates, touch it and it will be made into a soft material. The soft material is granulated through a 24-mesh sieve. After drying at 60°C-65°C, it is granulated through a 18-mesh sieve. uniform.

[0036] Particle 2: Pass the main ingredient and auxiliary materials through 80-mesh sieve for later use. Weigh repaglinide, HPMC (K4M), microcrystalline cellulose, and lactose according to the prescription, and mix them evenly with the method of equal increment...

Embodiment 2

[0040] Embodiment 2 liquid capsule

[0041] prescription

[0042]

[0043] Preparation:

[0044] Pass the metformin hydrochloride and repaglinide through a 120-mesh sieve and set aside. Weigh beeswax according to the prescription, add it to corn oil, heat and stir until dissolved, add the prescribed amount of metformin hydrochloride and repaglinide, mix and stir thoroughly to make a suspension, put it into a suitable transparent hard capsule, heat seal, and obtain .

Embodiment 4

[0045] Embodiment 4 Granules, tablets, capsules

[0046] prescription

[0047]

[0048] Preparation:

[0049] Pass the main ingredient and auxiliary materials through a 100-mesh sieve for later use. Weigh metformin hydrochloride, repaglinide and other excipients except magnesium stearate according to the prescription, mix them in equal increments, add binder to make soft material, and pass the soft material through a 24-mesh sieve to granulate, at 60°C After left and right drying, pass through a 18-mesh sieve for granulation, then add magnesium stearate and mix well.

[0050] The above granules can be directly divided into granules.

[0051] The above-mentioned granules are selected and packed in suitable capsule shells to make capsules.

[0052] The above granules are compressed with a suitable die to form tablets.

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PUM

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Abstract

The invention relates to a composite composition with metformin hydrochloride and repaglinide as active ingredients, a preparation method thereof and application thereof and belongs to the technical field of medicaments. The composite composition is a medicinal composition which is mixed by using the metformin hydrochloride and repaglinide as the active ingredients and by using a carrier and can be prepared into sustained-release tablets, sustained-release granules, sustained-release capsules, common troches and capsules, granules, dispersible tablets, chewable tablets, orally disintegrating tablets, buccal tablets, liquid capsules, soft capsules, drop pills and other oral preparations. The composite composition is used for treating patients with I-type diabetes or II-type diabetes (non-insulin-dependent diabetes) and has synergistic effect on controlling blood sugar.

Description

Technical field: [0001] The invention relates to a medicinal compound composition, more specifically relates to an oral preparation and application with metformin hydrochloride and repaglinide as active ingredients, and belongs to the technical field of medicine. Background technique: [0002] The incidence of diabetes is still increasing year by year. China has become the hardest-hit area, and the number of diabetic patients ranks second in the world after India. According to the data provided by the World Health Organization (WHO), the prevalence of diabetes in developed countries has reached as high as 5% to 10%, and in my country it is about 3%. According to the most conservative calculation, the number of diabetic patients in China increases by one million every year. There are 2,700 new cases; by 2030, the number of diabetic patients in the world will double compared with 2000. [0003] Analysts pointed out that in the future, the incidence of type 1 diabetes will rem...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/451A61K31/155A61P3/10
Inventor 吕霖
Owner 深圳南方盈信制药有限公司
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