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Slowly released clamycin capsule

A technology for capsules and sustained-release drugs, which is applied in the field of clarithromycin sustained-release capsules and its preparation, and can solve problems such as no clarithromycin sustained-release capsules and no products on the market.

Inactive Publication Date: 2002-10-09
GUANGZHOU PUIS PHARMA FACTORY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] So far, there have been no patents and literature development reports on the listing of clarithromycin sustained-release capsules at home and abroad, and no products have been listed.

Method used

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  • Slowly released clamycin capsule

Examples

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Effect test

Embodiment 1

[0017] (1) Preparation of mother core (blank pellet core):

[0018] Preparation: Commercially available blank pellets can be used, or a centrifugal coating granulator, high-speed stirring granulator, extrusion spheronizer or fluidized bed granulator can be used to prepare.

[0019] (2) Prescription of drug-containing pill core:

[0020] Clarithromycin 250g

[0021] Microcrystalline Cellulose 70g

[0022] 40g powdered sugar

[0023] 5% hypromellose appropriate amount

[0024] Sodium Lauryl Sulfate 0.3g

[0025] Make 1000 capsules

[0026] Preparation: Weigh 400g of the 40-mesh mother core, put it in the material chamber of a centrifugal coating granulator or a fluidized bed coating granulator, and mix clarithromycin powder, sugar powder, microcrystalline cellulose and ten Sodium dialkylsulfate mixed powder (120 mesh), put solid feeding chamber, 5% hydroxypropyl methylcellulose aqueous solution is binder, start centrifugal coating granulator o...

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Abstract

A slow-released clamycin capsule and its preparing process are disclosed. Said capsule is composed of the medicine pill as core with 0-10 mm in diameter and the isolating layer.

Description

[0001] The invention relates to a clarithromycin sustained-release capsule and a preparation method thereof. Background technique [0002] Clarithromycin is a semi-synthetic derivative of erythromycin. It is a semi-synthetic derivative after structural modification of erythromycin. The chemical name is 6-O-methyl erythromycin. The body 50 subunit binds to block the synthesis of protein, and then produces antibacterial effect. Compared with erythromycin, it has a wider antibacterial spectrum, and can also inhibit certain aerobic Gram-negative bacteria resistant to erythromycin, such as Haemophilus influenzae, Haemophilus parainfluenzae, and Moraxella catarrhalis; Inhibit the activity of most strains, the antibacterial activity against Staphylococcus aureus, Streptococcus pneumoniae and Streptococcus pyogenes is higher than erythromycin, and the activity against Chlamydia trachomatis and mycobacteria is 8~32 times stronger than erythromycin. Compared with erythromycin, the phar...

Claims

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Application Information

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IPC IPC(8): A61K9/22A61K9/28A61K9/52A61K31/04A61K31/7048
Inventor 贝庆生谢俊雄唐星
Owner GUANGZHOU PUIS PHARMA FACTORY
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