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16 results about "Biointerface" patented technology
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A biointerface is the region of contact between a biomolecule, cell, biological tissue or living organism or organic material considered living with another biomaterial or inorganic/organic material. The motivation for biointerface science stems from the urgent need to increase the understanding of interactions between biomolecules and surfaces. The behavior of complex macromolecular systems at materials interfaces are important in the fields of biology, biotechnology, diagnostics, and medicine. Biointerface science is a multidisciplinary field in which (bio)chemists who synthesize novel classes of biomolecules (PNA, peptidomimetics, aptamers, ribozymes, and engineered proteins) cooperate with scientists who have developed the tools to position biomolecules with molecular precision (proximal probe methods, nano-and micro contact methods, e-beam and X-ray lithography, and bottom up self-assembly methods), scientists who have developed new spectroscopic techniques to interrogate these molecules at the solid-liquid interface, and people who integrate these into functional devices (applied physicists, analytical chemists and bioengineers).
Preparation method and application of photonic crystal hydrogel film sensor with elastic modulus self-reporting function
This invention discloses a method for fabricating a photonic crystal hydrogel film sensor with a self-reporting elastic modulus function and its application. The method involves fabricating a hydrogel film with a periodic photonic crystal structure and constructing a bio-interface on its surface that can dynamically regulate cell adhesion, detachment, spreading, migration, proliferation, and differentiation. An optical imaging system is used to acquire images of the structural color changes of the photonic crystal hydrogel film. Image processing extracts color parameters, which are then converted into changes in reflected wavelength and the film deformation field. The elastic modulus of the film is calculated by inverting the deformation field generated by microspheres of known mass placed on the film surface, combined with an elasticity model. By combining the cell-interface interaction deformation field, the cell-interface interaction force and its spatial distribution can be obtained. A photonic crystal hydrogel film sensor with a self-reporting hardness function is constructed. This method achieves integrated biomechanical research combining dynamic regulation and real-time monitoring, offering advantages such as non-destructive operation, real-time imaging, and acquisition of mechanical spatial distribution.
Owner:JIANGSU UNIV
Compositions and methods for capturing and releasing cells containing CD44 antigen.
A composition and method for capturing and releasing cells containing CD44 antigen, comprising cholesterol-aptamers, silver nanoparticle-modified aptamers, and bleomycin-ferrous ion complexes, exhibits higher biocompatibility and stability, facilitating the formation of a biointerface for the efficient capture and release of mesenchymal stem cells. Applying the composition of this invention to the electrochemical detection of cell capture and release offers advantages such as mild reaction conditions, simplicity, speed, and sensitivity, making it easy to integrate with other automated reaction interfaces for commercial development. Furthermore, it can be combined with electrochemical biochip sensor arrays to achieve even more convenient capture, detection, and release of mesenchymal stem cells.
Owner:章毅 +7
Multivalent aptamer modified near-infrared light-operated biological interface as well as preparation method and application of multivalent aptamer modified near-infrared light-operated biological interface
The invention belongs to the technical field of crossing of biomedical engineering and nano biomedicine, and discloses a multivalent aptamer modified near-infrared light-operated biological interface as well as a preparation method and application of the multivalent aptamer modified near-infrared light-operated biological interface. UCNPs capable of initiating a hybridization chain reaction (HCR) is modified on a substrate plate interface, then a nucleic acid aptamer of high expression protein on the surface of CTC is obtained through screening by an exponential enrichment ligand systematic evolution (SELEX) technology, and then HCR is initiated on the surface of the substrate plate, so that a multivalent nucleic acid aptamer modified near-infrared light response interface is constructed. Based on the multivalent ligand-receptor effect, the compound is used for specific capture of CTC, and the capture efficiency is improved. Besides, the UCNPs can be used for converting near-infrared light into ultraviolet light, so that the control of the near-infrared light on ultraviolet light sensitive molecules in the DNA sequence is realized, and the separation and release of the CTC are regulated and controlled.
Owner:INSTITUTE OF BASIC MEDICAL SCIENCES CHINESE ACADEMY OF MEDICAL SCIENCES
A thin film having a multi-level microstructure surface and a preparation method and application thereof
This invention discloses a thin film with a multi-level microstructure surface, its preparation method, and its applications, belonging to the field of thin film microstructure construction technology. This invention is the first to apply the dynamic behavior of fluids during stretching motion to the construction of multi-level microstructures on a thin film surface. Compared to traditional microfabrication techniques, the stretch flow curing method's most significant advantage lies in its extremely simplified process flow and high flexibility. The entire preparation process includes only two key stages—stretch flow molding and curing—significantly reducing equipment complexity and operational difficulty. The stretch flow curing method not only provides a novel, efficient, and low-cost solution for surface microstructure fabrication but also demonstrates broad application potential in functional thin films, flexible electronics, optical coatings, biointerfaces, and microfluidic devices.
Owner:CHENGDU UNIV OF INFORMATION TECH
A method for preparing a biomineralized-coated bacteria, the biomineralized-coated bacteria and applications thereof
The application provides a preparation method of a biomineralization coated bacterium, the biomineralization coated bacterium and application thereof, and relates to the technical field of microbial medicine preparation.The preparation method of the biomineralization coated bacterium comprises the following steps: mixing bacteria and a polyvinylpyrrolidone solution to obtain a bacterium suspension; mixing a CaCl2 solution with the bacterium suspension, and then adding an Na2CO3 aqueous solution; stirring for 0.5-1.5 hours, centrifuging, collecting the precipitate and obtaining the biomineralization bacterium. The method is simple and convenient, and is used for assisting biological interface mineralization through electrostatic interaction to deposit a super-resistant and self-adapting bacterium protection coating. The method is universal for coating various species including obligate and facultative anaerobes. The preparation procedure and the formed coating have negligible influence on the activity of the bacterium, and the bacterium is free from the double invasion of gastric acid and bile acid, so that the activity and quantity of the bacterium reaching the intestinal tract are ensured.
Owner:RENJI HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
Photosynthesis-imitating radio stimulation hydrogel as well as preparation method and application thereof
The invention discloses photosynthesis-imitating radio stimulation hydrogel as well as a preparation method and application thereof. The hydrogel is prepared by taking polyvinylpyrrolidone, pyrrole, protein and sodium copper chlorophyllin as raw materials. By imitating the primary photochemical reaction in photosynthesis, a high-conductivity and high-compliance hydrogel biological interface in which the chlorophyll-protein compound efficiently captures light energy and the modified polypyrrole nano particles quickly diffuse carriers is constructed, and the generated photocurrent can effectively induce action potential, so that the bioactivity of the hydrogel is improved. Accurate regulation and control of nerve excitation and composite muscle action potential are realized, and a key basis is provided for regulation of electrophysiological signals in a nerve repair process; the biological interface exhibits multiple therapeutic effects, including immediate reconstitution of neural function, promotion of neural repair while inhibiting muscle atrophy, and acceleration of epidermal wound healing.
Owner:NANJING TECH UNIV
Vascularized multi-tissue interaction organ chip and construction method and application thereof
PendingCN121801701Astay independentconsistent with interaction characteristicsCompound screeningBioreactor/fermenter combinationsVascularizesBiointerface
The invention belongs to the technical field of organ chips and biological manufacturing, and relates to a vascularized multi-tissue interaction organ chip based on a phase change sacrificial structure and a construction method and application thereof. According to the invention, collaborative construction of multiple tissue chambers and a blood vessel-parenchymal tissue biological interface is realized through a continuous phase change process of the sacrificial hydrogel material; according to the organ chip disclosed by the invention, an extra diaphragm or complex processing is not needed, the continuity and the bionic property of a multi-tissue interaction interface are maintained, the simulation of signal exchange and a pathological process among multiple tissues in a body is facilitated, and the organ chip has higher bionic property and applicability in applications such as complex physiological interaction modeling, drug evaluation and disease mechanism research.
Owner:XI AN JIAOTONG UNIV
A method and system for hydration-mediated energy restoration
This invention discloses a method and system for hydration-mediated energy repair, belonging to the field of biointerface microenvironment regulation technology. This method constructs a stable and ordered hydration microenvironment at the biointerface, using an ordered water molecule hydration layer as a carrier for the conduction of a mild physical energy field. Combined with the synergistic regulation of hydration parameters and energy output parameters, it optimizes energy conduction and improves microenvironmental stability at the biointerface. The system mainly includes a hydration regulation unit, an energy output unit, a synergistic control unit, and a carrier substrate. Relying on the coordinated operation of two modules, it overcomes the shortcomings of traditional single-energy-action methods, such as high energy loss and weak targeting. The overall solution of this invention is positioned for non-therapeutic daily microenvironment conditioning. The solution architecture is novel, its operation is mild, and its feasibility is strong, possessing good application and promotion value.
Owner:朱延秋
Water and soil loss management and control early warning system and method based on Internet of Things
PendingCN122084043Adegree of reductionReduce governance costsMeasurement devicesAlarmsEarly warning systemMicroorganism
The invention discloses a water and soil loss management and control early warning system and method based on the Internet of Things, and relates to the technical field of water and soil conservation and ecological environment monitoring. Core parameters such as interface double-electric-layer relaxation time sequential change rate, interface tension attenuation amplitude and capacitance distortion coefficient are calculated, microscopic signals of soil colloid binding water stripping and interface instability are captured, and the signals are obviously abnormal 10-15 days before water and soil loss macroerosion occurs; meanwhile, through soil body crack nucleation infrasound-acoustic emission coupling monitoring, soil body microcrack nucleation and expanded infrasound and acoustic emission signals are captured, the signals appear 7-10 days earlier than slope macroscopic deformation, through two-dimensional precursor signal coupling recognition, early-stage pre-judgment of water and soil loss is achieved, and the early-stage early-stage early-stage early-stage early-stage early-stage early-stage early-stage early-stage early-stage early-stage early-stage early-stage early-stage early-stage early-stage early-stage early-stage early-stage early-stage early- the ecological damage degree and the treatment cost caused by water and soil loss are reduced.
Owner:CHINA THREE GORGES UNIV
STM32-based embedded precise spinal cord striking instrument control method and system
The invention relates to the field of embedded precise control, and provides an embedded precise spinal cord striker control method and system based on STM32, and the method comprises the steps: synchronously sampling capacitance field intensity data and touch pressure data, and generating a biological interface original data set; extracting a capacitance change gradient value and a pressure mutation gradient value, constructing a real-time contact confidence value in combination with a global gain operator, and obtaining a zero potential surface coordinate of the biological tissue; a primary voltage reference value is extracted according to the target striking speed, a driving voltage control word is generated in combination with hardware physical parameters, and an electromagnetic valve time sequence control instruction is generated based on biological tissue zero potential surface coordinates, the target striking speed and the striking depth; and capturing a real-time displacement pulse sequence, analyzing the actual strike depth and the actual strike speed, and calculating a target deviation value to generate a damage consistency evaluation coefficient. According to the method, multi-mode heterogeneous feature synchronous perception and reverse dynamic physical compensation are fused, and execution control and digital effect auditing closed loops of spinal cord injury modeling are constructed.
Owner:SUZHOU LOUHAISI TECH CO LTD
Autologous keratinocyte tissue fragment-activated plasma matrix composite membrane, and preparation method and application thereof
This invention relates to the fields of biomedical engineering and regenerative medicine, and particularly to a plasma matrix composite membrane activated by autologous keratinized epithelial tissue fragments, its preparation method, and its applications. The composite membrane is obtained by mixing autologous keratinized epithelial tissue fragments with a liquid autologous plasma matrix in a specific ratio, utilizing tissue factors on the surface of the tissue fragments to trigger platelet activation, spontaneously forming a gel, and then pressing it into a membrane. This invention is the first to utilize the biointerface of autologous keratinized epithelial tissue fragments to activate platelets, eliminating the need for exogenous thrombin and achieving completely autologous in-situ gelation. The composite membrane formed after pressing possesses excellent mechanical properties and barrier function, and can be prepared in a single operation in the operating room without the need for in vitro cell culture. The composite membrane of this invention is used for oral soft tissue augmentation, such as widening of keratinized gingiva and alveolar ridge soft tissue augmentation, and has advantages such as no donor site damage, high biosafety, and ease of operation.
Owner:HUBEI PRIME SHIELD BIOTECHNOLOGY CO LTD
Hollow magnetoelectric nanoparticles and preparation method and application thereof
The invention provides a hollow magnetoelectric nano-particle which is prepared by the following steps: firstly, forming a hollow FO nano-particle with a hollow Fe3O4 spherical structure under the composite action of solvothermal reaction, citric acid reduction, urea alkaline environment and polyacrylamide controlled nucleation / viscosity regulation; tetrabutyl titanate is added, a compact TiO2 (TO) layer is deposited through a sol-gel method, and hollow FO (at) TO nanoparticles are prepared; finally, barium hydroxide is converted into a BaTiO3 (BTO) phase through a hydrothermal reaction, and the hollow magnetoelectric nano-particle HFO (at) BTO nano-particle with the core-shell structure is obtained. Compared with a solid structure, the hollow magnetoelectric nanoparticles have remarkable advantages in the aspects of magnetism-force-electricity conversion efficiency, biological interface stimulation performance and in-vivo dispersion stability by increasing strain space, enlarging interface coupling area and improving mechanical response speed and electric output efficiency; the method is a preferable structural form for constructing a high-performance wireless magnetoelectric nerve regulation material.
Owner:SICHUAN UNIV
A method for preparing a nanoplasma metasurface biosensor and its application in detecting new psychoactive substances.
PendingCN122084580AMaterial analysis by optical meansLaboratory glasswaresAntigenPolyethylene glycol
This invention discloses a method for preparing a nanoplasmic metasurface biosensor and its application in the detection of new psychoactive substances, belonging to the field of environmental monitoring technology. The invention forms a nanoplasmic metasurface by fabricating a nanopore array and a plasmonic-active metal layer on the sensor surface. The metal nanostructure generates a strong local electromagnetic field enhancement effect under photoexcitation. Subsequently, a stable, non-specific adsorption-resistant biological interface is formed through modification with a carboxyl / methoxy mixed thiol-polyethylene glycol self-assembled monolayer. After activation with N-hydroxysuccinimide / 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide, the surface carboxyl groups are converted into active esters, facilitating covalent coupling of specific monoclonal antibodies against the target substance. Finally, antibody coupling allows the sensor to capture the target analyte through antigen-antibody specific binding, causing a change in the interfacial refractive index, which in turn leads to a shift in the plasmonic resonance peak, achieving optical signal conversion.
Owner:FUZHOU UNIV
Biosensor based on exchange coupling effect and magneto-elastic coupling effect and preparation method thereof
The application provides a biosensor based on exchange coupling effect and magnetic elastic coupling effect and a preparation method thereof, and belongs to the field of biosensors. The biosensor comprises, from bottom to top, a flexible substrate, a silver interdigital electrode prepared by a magnetron sputtering process arranged on the surface of the flexible substrate, a PDMS stress transfer layer arranged on the interdigital electrode, a magnetic sensitive unit composed of magnetostrictive layers and soft magnetic layers alternately stacked, and a gold biological interface layer arranged on the topmost layer. The application significantly reduces the interface impedance and optimizes the signal collection efficiency by introducing the silver interdigital electrode. The weak surface stress generated by the combination of biological molecules is efficiently converted into a significant change in magnetic anisotropy by utilizing the synergistic effect of exchange coupling and magnetostrictive effect in the magnetic multilayer film. The biosensor not only solves the problem of slow response to surface stress of traditional devices, but also has excellent mechanical flexibility, high signal-to-noise ratio and high sensitivity, and is suitable for label-free detection of complex biological samples.
Owner:TAIYUAN UNIVERSITY OF TECHNOLOGY
A cell membrane biomimetic nanorecognition material, a preparation method and application thereof
The application provides a cell membrane biomimetic nanorecognition material and a preparation method and application thereof, adopts magnetic nanoparticles as a carrier, fixes cell membranes to the magnetic carrier through a biological orthogonal reaction, finally obtains the cell membrane-based biomimetic nanorecognition material, and is used for the identification and risk assessment of unknown pollutants in food; the application combines the high magnetic response of the magnetic nanoparticles and the characteristics of the cell membrane-mediated highly complex biological interface performance, and wraps the active cell membranes containing target receptors on the surface of the magnetic nanoparticles through a covalent fixation mode, maximally maintains the integrity of the cell membranes and the three-dimensional structure and biological activity of the membrane receptor proteins thereon, gives the biomimetic nanomaterial excellent targeting performance, realizes the specific screening and rapid magnetic separation of unknown chemical risk substances in a complex food matrix, improves the identification efficiency of unknown chemical risks in food, and provides a new idea of toxicity-oriented screening of potential pollutants in food.
Owner:SHAANXI UNIV OF SCI & TECH
A device and method for real-time detection of single nanoparticle protein crowns
This invention discloses a device and method for real-time detection of single-nanoparticle protein crowns. The device includes a surface plasmon resonance imaging (SPRM) device comprising an optical module, a sample reaction unit, and a signal acquisition and analysis module. The SPRM device includes a laser emission module for heating single nanoparticles. This invention integrates the SPRM device with a laser emission module capable of heating single nanoparticles, achieving precise temperature control of single-particle protein crowns and enabling real-time, label-free, high spatiotemporal resolution detection of the protein crown formation process. Furthermore, this invention provides a high-precision experimental platform for quantitatively studying the thermodynamic processes of protein-nano interfaces and provides important theoretical and technical support for the design of nanomedicine carriers and biointerface engineering.
Owner:NANJING UNIV +1