30 results about "Biointerface" patented technology

A biointerface membrane for an implantable device including a nonresorbable solid portion with a plurality of interconnected cavities therein adapted to support tissue ingrowth in vivo, and a bioactive agent incorporated into the biointerface membrane and adapted to modify the tissue response is provided. The bioactive agents can be chosen to induce vascularization and/or prevent barrier cell layer formation in vivo, and are advantageous when used with implantable devices wherein solutes are transported across the device-tissue interface.

The present invention provides a biointerface membrane for use with an implantable device that interferes with the formation of a barrier cell layer including; a first domain distal to the implantable device wherein the first domain supports tissue attachment and interferes with barrier cell layer formation and a second domain proximal to the implantable device wherein the second domain is resistant to cellular attachment and is impermeable to cells. In addition, the present invention provides sensors including the biointerface membrane, implantable devices including these sensors or biointerface membranes, and methods of monitoring glucose levels in a host utilizing the analyte detection implantable device of the invention. Other implantable devices which include the biointerface membrane of the present invention, such as devices for cell transplantation, drug delivery devices, and electrical signal delivery or measuring devices are also provided.

Disclosed herein are biointerface membranes including a macro-architecture and a micro-architecture co-continuous with and bonded to and/or located within at least a portion of the macro-architecture. The macro- and micro-architectures work together to manage and manipulate the high-level tissue organization and the low-level cellular organization of the foreign body response in vivo, thereby increasing neovascularization close to a device-tissue interface, interfering with barrier cell layer formation, and providing good tissue anchoring, while reducing the effects of motion artifact, and disrupting the organization and/or contracture of the FBC. The biointerface membranes of the preferred embodiments can be utilized with implantable devices such as devices for the detection of analyte concentrations in a biological sample (for example, from a body), cell transplantation devices, drug delivery devices, electrical signal delivering or measuring devices, and/or combinations thereof.

The present invention relates generally to biointerface membranes utilized with implantable devices, such as devices for the detection of analyte concentrations in a biological sample. More particularly, the invention relates to novel biointerface membranes, to devices and implantable devices including these membranes, methods for forming the biointerface membranes on or around the implantable devices, and to methods for monitoring glucose levels in a biological fluid sample using an implantable analyte detection device.

Disclosed herein is an analyte sensing biointerface that comprises a sensing electrode incorporated within a non-conductive matrix comprising a plurality of passageways extending through the matrix to the sensing electrode. Also disclosed herein are methods of manufacturing a sensing biointerface and methods of detecting an analyte within tissue of a host using an analyte sensing biointerface.

Silicone containing reactive monomers with hydrophilic end-groups of formula I useful in the manufacture of biocompatible medical devices are disclosed, wherein R₁ is H or CH₃, a is 0 or 1, p is an integer from 1 to 6, q is an integer from 1 to 3 and for each q, the end groups R₅₁, R₅₂, R₅₃ are independently an alkyl, alkyl ether, trimethylsiloxy group, or a substituted or non-substituted aromatic group and at least one of them has a hydrophilic group attached, preferably to the terminal end of R₅₁, R₅₂, R₅₃, X is O or NR₅₄, where R₅₄ is H or a monovalent alkyl group with 1 to 4 carbons, n is an integer from 1 to 100, R₂ and R₃ are independently an alkyl, alkyl ether, or a substituted or non-substituted aromatic group, preferred R₂ and R₃ include methyl, ethyl, and phenyl, L is a divalent linker comprising substituted and unsubstituted alkylene groups having 1-14 carbon atoms, which may be straight or branched, substituted and unsubstituted alkoxy groups having 2-12 carbons, polyethers, oxazolines, and substituted and unsubstituted heterocyclic groups. Suitable substituents include aryl, amine, ether, amide, hydroxyl groups, combinations thereof and the like. In another embodiment, L comprises a straight or branched alkylene group having 2 to 12 carbons. The reactive monomers combine oxygen permeable silicone components with hydrophilic terminal groups capable of reaching to the device-bio-logic interface thus providing bulk and surface characteristics useful in the manufacture of medical devices, particularly ophthalmic devices.

Biocompatible electrodes with smaller geometric area improve the selectivity of the neural recording and stimulation applications. A volume within the electrode back plane of a micro-reaction chamber (μRC) is used to confine and sequester an electrochemical reaction used for charge passage. The μRC electrode decreases impedance and improves charge storage capacity without altering the geometry of the active site.

Described is a biointerface using near-infrared quantum dots for surface plasmon resonance imaging biosensors.

The invention belongs to the field of environmental science and engineering, and discloses a system for detecting microbial interface adhesion based on surface plasmon imaging and method. The system for detecting microbial interface adhesion based on surface plasmon imaging is based on surface plasmon resonance microscopy (SPRM) and self-assembled monolayers (SAMs), advantages of being label-free,real-time in observation and high in time resolution are achieved, the adhesion kinetic parameters of bacteria on different interfaces such as an adhesion speed and a kinematic phenotype can be accurately determined by an online counting method, and the time constant of adhesion to the surface can be obtained by calculating and fitting.

The present invention is directed to a versatile and high performance zwitterionic CP platform, which integrates all desired functions into one material. This zwitterionic CP consists of the conducting backbone and multifunctional zwitterionic side chains. Non-conducting zwitterionic materials gain electronic conductivity through the conducting backbone and CPs obtain excellent biocompatibility, sensitivity to environmental stimuli and controllable antifouling properties via multifunctional zwitterionic side chains. Unique properties from two distinct materials (conducting materials and zwitterionic materials) are integrated into one material without sacrificing any properties. This platform can potentially be adapted for a range of applications (e.g. bioelectronics, tissue engineering, wound healing, robotic prostheses, biofuel cell, etc.), which all require high performance conducting materials with excellent antifouling/biocompatibility at complex biointerfaces. This conducting material platform will significantly advance the development of conducting polymers in the field of biomedicine and biotechnology.

A photovoltaic unit that includes a biological interface for sensing an electrical signal from the biological tissue, the biological interface including a multilayered piezoelectric amplifier including a composite impulse generating layer including a matrix of a piezo polymeric material and dispersed phases including piezo nanocrystals and carbon nanotubes. The photovoltaic unit also includes a transducer structure comprising a fiber substrate having quantum dots present on a receiving end of the fiber. The receiving end of the fiber receiving the electrical signal. The quantum dots converts the electrical signal to a light signal.

The invention belongs to the technical field of nano materials, and particularly relates to a shape-controllable silicon dioxide nano array and a preparation method and application thereof. According to the silicon dioxide nano array, the array height is 8-46 nm, and the distribution density is 210-3100/mu m < 2 >. The preparation method of the nano array comprises the following steps: forming a silicon nano array on the surface of a substrate by adopting an oil/water double-phase single micelle epitaxial growth method and taking CTAB as a structure-directing agent, TEOS as a precursor and NaOH as a catalyst; the substrate can be a glass sheet, a silicon wafer, a glass rod, a glass tube, a micro-fluidic chip and the like. The silicon dioxide nano array can endow the substrate with a rough surface structure, and the interaction between the substrate and tumor cells and the biological interface is enhanced. Compared with a substrate modified by a smooth silicon layer, the cell adhesion capacity is remarkably improved. The device formed by nesting the glass rod with the silicon dioxide nano array growing on the surface and the glass tube can be used for separating tumor cells from whole blood.

Biological interfaces configured to retain and effectively maintain non-mammalian cells are disclosed. The biological interface may include one or more of a nutritional phase, a binder, a bioactive agent, a liquid-containing phase. The biological interface may be patterned. The biological interface can specifically retain and effectively maintain specific non-mammalian cell types, such as spores of seaweed. The biological interface is used for planting algae, such as red-skin algae and kelp.