28 results about "Bioelectronics" patented technology

The invention discloses a degradable, asymmetric-adhesion and non-swelling Janus hydrogel adhesive as well as a preparation method and application thereof, and belongs to the technical field of functional composite materials and preparation thereof. The problems that an existing Janus hydrogel cannot be degraded, is weak in adhesive force, adheres and is high in swelling are solved. Polyethylene glycol with double bonds, sodium alginate and chitosan are used for physical and covalent cross-linking, a degradable hydrogel substrate is constructed and then soaked in a phosphate buffer solution for swelling equilibrium, then a solution containing chitosan is used for preparing an adhesion coating, and the degradable and asymmetrically-adhered non-swelling Janus hydrogel adhesive is obtained. The adhesive can be applied to the biomedical fields of wound healing anti-adhesion, in-vivo degradability, intestinal repair and the like, and can also be used for adhesion of bioelectronics, epidermal physiological signal monitoring sensors, epidermal muscle fatigue monitoring sensors, rat subcutaneous muscle physiological signal monitoring sensors and muscle fatigue monitoring sensors.

The invention discloses a preparation method of high-toughness and high-conductivity deep eutectic gel. The preparation method comprises the following steps: (1) mixing PVA and PEDOT: PSS solutions with water to obtain a PVA / PP aqueous solution; (2) adding DBSA into the PVA / PP aqueous solution, and mixing to obtain a PVA / PP / DBSA aqueous solution; (3) performing freeze thawing cycle treatment on the PVA / PP / DBSA aqueous solution to obtain PVA / PP / DBSA hydrogel; (4) mixing the ChCl with the Gly to obtain ChCl / Gly DES (Diethylbenzene Sulfonate); and (5) carrying out solvent exchange on the PVA / PP / DBSA hydrogel and ChCl / Gly DES, so as to obtain the PVA / PP / DBSA / DES deep eutectic gel. The raw materials are cheap and easily available, and the preparation method is simple and feasible. The obtained deep eutectic gel has high strength, high toughness, high conductivity and weather-resistant stability, and can be applied to various flexible bioelectronics.

A conducting composition includes a topological polymer (e.g., a polyrotaxane polymer) and poly(3,4-ethylene-dioxy thiophene):polystyrene sulfonate (PEDOT:PSS). Devices may include a conducting layer including the conducting compositions, e.g., a device comprising a conducting layer, wherein the conducting layer includes a polyrotaxane polymer and a PEDOT:PSS array. The devices are useful in bioelectronics, including high-resolution electrophysiological monitoring of deformable tissues and localized neuromodulation for high-precision control of individual muscle activities.

A permanent fluidic magnet device includes a carrier fluid, and a plurality of non-Brownian nanomagnets disposed within the carrier fluid in a three-dimensional (3D) oriented and ramified magnetic (ORM) network structure. The permanent fluidic magnet device can be utilized in a system for detecting biomechanical signals from a subject, for example, cardiac signals, acoustic signals, etc. The permanent fluidic magnet device can also be implemented in a liquid robot system where the permanent fluidic magnet device can be actuated by an external magnetic field.

The present invention relates to a composition comprising a polymer of formula (I) and one or more compounds of formula (II) or formula (III), and to its use in the treatment of diseases (e.g., cancer, cardiovascular disease, infectious disease, or neurodegenerative disease). The polymer of formula (I) and one or more compounds of formula (II) or formula (III) have the following structure [Formula 1] Represented by JPEG2026513146000041.jpg60159, A, E, Z, Z', R1, R2, R3, R3', R4, R4', R5, R6, R7, R8, R9, R 10 n, m, a, y, and q are as defined in the specification.

The invention provides an artificial intelligence-based electrical stimulation method and system, and relates to the technical field of bioelectronics, and the method comprises the steps: firstly, synchronously collecting an electromyographic signal and a kinematics signal which are triggered by the electrical stimulation acting on a target muscle in a first period; then, analyzing and acquiring a first type of characteristic parameters representing a nerve recruitment dynamic state based on the electromyographic signal, and analyzing and acquiring a second type of characteristic parameters representing a muscle contraction mechanical state based on the kinematics signal; then, carrying out dynamic weight fusion on the first type of characteristic parameters and the second type of characteristic parameters to obtain a comprehensive muscle state index; then, according to the deviation between the comprehensive index and a preset target range, generating an adjusting instruction for adjusting the electrical stimulation parameters; and finally, adjusting the output electrical stimulation waveform parameters in real time according to the adjustment instruction in a second period following the adjustment instruction. Through multi-mode signal fusion and closed-loop feedback, self-adaptive accurate regulation and control of electrical stimulation parameters are realized.

In one aspect, the present disclosure provides nano and microstructures of conducting polymers which may be used in the treatment of neuron regeneration. In some embodiments, the microstructures may be a microcup or a nanogroove structure. The present disclosure also provides methods of preparing the conducting polymer coated microstructures and methods of using these compositions or structures.

The invention relates to a flexible brain-computer interface with high mechanical stability and a preparation method, and belongs to the field of bioelectronics. The interface comprises a flexible polyimide substrate; the composite metal microelectrode layer is formed on the flexible polyimide substrate through a vacuum evaporation process, the composite metal microelectrode layer comprises a chromium layer serving as a transition bonding layer and a gold layer serving as a conductive functional layer, the chromium layer is in direct contact with the flexible polyimide substrate so as to enhance the interface bonding strength, and the gold layer covers the chromium layer; and the photosensitive polyimide packaging layer is formed by patterning through a photoetching process and covers the composite metal microelectrode layer and part of the flexible polyimide substrate, and the photosensitive polyimide packaging layer is provided with a window which exposes part of a gold layer in the composite metal microelectrode layer to serve as an electrode contact site and an electrode bonding pad. The core problems that the interface bonding force between the existing titanium-based metal microelectrode and the flexible substrate is weak, and the mechanical-electrical stability is difficult to cooperate under long-term implantation are solved.

The invention relates to the technical field of biological conduction, in particular to a composite material and a rapid preparation method. The invention provides a bioelectronics-oriented novel flexible conductive composite material. The bioelectronics-oriented novel flexible conductive composite material is prepared by performing illumination molding on a mixed system. The preparation method comprises the following steps: dissolving polyether F127-diacrylate serving as an elastic network skeleton in a conductive polymer solution and uniformly doping a conductive polymer to prepare semi-interpenetrating double-network hydrogel; afterwards, excessive small molecules are removed through mild glacial acetic acid treatment, and chain segments are induced to be rearranged. The biological flexible conductive material prepared by the invention has excellent conductivity, mechanical property and biocompatibility, and a biological flexible electrode with good performance can be obtained by combining a 3D printing technology. According to the flexible electrode, the bottlenecks that an existing flexible electrode is low in conductivity, complex in packaging and limited in large-size printing are improved from a material system to a manufacturing process, and a universal and efficient new scheme is provided for implantable soft bioelectronics.

The present invention relates to a composition comprising a polymer of formula (I) and one or more compound of formula (II) or formula (III), and uses thereof in treating a disease, such as cancer, cardiovascular diseases, infections, or neurodegenerative diseases; wherein the polymer of formula (I) and the one or more compound of formula (II) or formula (III) are represented by the structures; and A, E, Z, Z′, R1, R2, R3, R3′, R4, R4′, R5, R6, R7, R8, R9, R10, n, m, a, y and q are as defined in the specification.

The present disclosure describes electrically stimulating biological systems using meshes, wherein the mesh comprises nanoscale wires and / or nanoelectronics. These may be embedded as a scaffold in biological structures, such as tissues, organoids, organs, organisms, and the like. These may be connectable to an external device to determine a property of the scaffold and / or to apply a stimulus to the biological structure. Certain embodiments are Al-driven systems designed for applications such as drug screening, stem cell therapy, or the like. In addition, some embodiments are directed to predictive models that can be used to predict and / or control the biological structure. For example, certain cells may be caused to mature more quickly, and / or the functionality of the biological structure may be enhanced or inhibited by using such models to apply suitable electrical stimuli to the biological structure, and / or portions of the biological structure.

In one aspect, the present disclosure provides organic semiconductors (OSNTs) as well as high-performance electrochemical devices based on the present OSNTs for the production of micro and nano-scale actuators. The present OSNTs may be used in several applications, including movable and implantable interface devices, such as flexible neural microelectrodes. Also provided herein are flexible neural microelectrodes based on conjugated polymer actuators.

The application provides a cell electrotransformation instrument and a cell electrotransformation method, which can be applied to the field of bioelectronics and the like, and is used for solving the problem of low reliability of cell electrotransformation. The cell electrotransformation instrument comprises: a first electrode layer and a second electrode layer attached to different surfaces of an insulating layer respectively, the insulating layer has at least one hole, the hole and the surface to which the first electrode layer is attached and the surface to which the second electrode layer is attached form a cavity; a first friction layer is adjacent to the first electrode layer, and a second friction layer is adjacent to the second electrode layer; a rotating device comprises a fixed component and a rotating component, the first electrode layer, the second electrode layer and the insulating layer are fixed to the fixed component, the first friction layer and the second friction layer are fixed to the rotating component, the rotating component drives the first friction layer to rotate at a position with a first gap from the surface of the first electrode layer, and the rotating component drives the second friction layer to rotate at a position with a second gap from the surface of the second electrode layer.

A method of making a nanoporous membrane is constructed using an array of sacrificial nanopillars that print removable material on a substrate. After continuous deposition or even of covering layers with different properties, the sacrificial nanostructure is dissolved, and finally the nanoporous membrane with nanopores, channels and cavities designed with nanoscale sizes and geometrical shapes is formed. Thus, unprecedented unique functions are achieved in various technical fields (e.g., bioartificial organs, nanoelectronics, bioelectronics, molecular sensors and biomedical applications).

The invention discloses a flexible micro electrical stimulator capable of being wound and adhered to peripheral nerve tracts and a preparation method and application thereof, and relates to the technical field of crossing of neural engineering, bioelectronics and medical instruments. A first insulation layer, a first friction electrode layer, a middle isolation layer, a second friction electrode layer and a second insulation layer are assembled layer by layer; the first insulation layer and the second insulation layer are self-adhesion polyurethane layers, and the first friction electrode layer, the middle isolation layer and the second friction electrode layer are packaged in the first insulation layer and the second insulation layer; the first friction electrode layer is a gold foil, and the surface of the gold foil is electroplated with a PEDOT: PSS plating layer formed by a 3, 4-ethylenedioxythiophene monomer and polystyrene sulfonate; the second friction electrode layer is gold foil or aluminum foil. According to the invention, macro-scale contact-separation type friction power generation is realized through ultrasonic driving, and the device has good output performance, long-term stability and nerve stimulation effect.

The invention relates to ultraviolet-cured high-viscoelasticity ionic conductive hydrogel as well as a preparation method and application thereof, and belongs to the technical field of functional polymer materials and bioelectronics. According to the hydrogel, an ultraviolet light sensitive zwitterionic monomer (SBMA), a high-density cationic monomer (DMDMAC), a cross-linking agent (PEGDA) and a photoinitiator are selected, and under the ultraviolet light exposure condition, the photoinitiator is decomposed to generate active free radicals to trigger a cross-linking polymerization reaction. The hydrogel has a three-dimensional network structure, integrates softness, high stretchability, strong tissue adhesion and high conductivity, and has fracture tensile strain gt; the adhesive strength is gt; and the ionic conductivity can reach 2.24 S / m. The preparation process is simple, rapid in-situ forming of the hydrogel on the skin surface can be achieved, the flexible biological electrode prepared based on the hydrogel has low skin-electrode interface impedance, motion artifacts are effectively inhibited, and the flexible biological electrode is suitable for long-term, dynamic and high-signal-to-noise-ratio biological electric signal monitoring and has good application prospects. And good biocompatibility and wearing comfort are achieved.

An intrinsically stretchable organic electrochemical transistor with overall performance benchmarkable to a rigid device. The high performance was realized by reducing the oxygen level (PO2) of the stretchable substrates, which facilitates the de-doping of the conducting polymer channel. The high-performance intrinsically stretchable OECT is usable not only as a new device paradigm to impact the field of soft bioelectronics and promote the use of tissue-like stretchable OECTs in areas such as epidermal biosensing, soft neuromorphic computing and soft human-machine interfaces, but also to reveal a new critical parameter to alter the performance of stretchable conducting polymer-based devices.

The invention discloses MOF (Metal Organic Framework) enzyme-loaded gel as well as a preparation method and application thereof, and the preparation method comprises the following steps: when a gel precursor solution is prepared, adding enzyme-loaded MOF particles into the gel precursor solution, uniformly stirring, and incubating into gel to obtain the MOF enzyme-loaded gel. The enzyme-loaded MOF composite gel can be used for preparing a dopamine sensor, an epinephrine sensor or a noradrenaline sensor. According to the MOF enzyme-loaded gel disclosed by the invention, the size of the enzyme-loaded MOF is uniform, the metal organic framework around the enzyme can stabilize the structure of the enzyme to a great extent, the protein conformation of the enzyme is prevented from being changed, and the MOF enzyme-loaded gel has good biocompatibility, has enzymatic electron transfer and ion transfer capabilities, and can be widely applied to bioelectronics devices, bioelectronics devices, bioelectronics devices, bioelectronics devices, bioelectronics devices, bioelectronics devices, bioelectronics devices, bioelectronics devices, bioelectronics devices, bioelectronics devices, bioelectronics devices, bioelectronics devices and bioelectronics devices. A sensor, such as a dopamine sensor, a motion sensor; the preparation process is mild and efficient, and the material is environment-friendly and has good application prospects.

This invention relates to the field of fatigue monitoring technology, specifically to a real-time muscle fatigue monitoring method based on flexible bioelectronics. The method includes: S1: Using a flexible bioelectronic monitoring component attached to the target muscle group region, surface electromyography (EMG) signals, surface deformation signals, and contact load signals are simultaneously collected from the target muscle group region after the user initiates a target training movement, constructing a dynamic anchoring reference set for the target muscle group region; S2: Aligning and comparing subsequently collected signals with the dynamic anchoring reference set, calculating neural recruitment offset, deformation response delay, and load distribution offset, respectively, to construct a fatigue evolution feature set for the target muscle group region; S3: Performing continuous time-series analysis to identify fatigue propagation paths and compensatory takeover trends within the target muscle group region, determining the real-time fatigue level of the target muscle group region and the corresponding injury risk warning results. This invention enhances the forward-looking nature and intervention guidance value of fatigue assessment.

This invention belongs to the field of bioelectronics and edge computing technology, specifically a low-power, monolithically integrated adaptive electronic signal processing system. The system integrates a signal input interface, a two-stage low-noise amplification and filtering module, a neuromorphic signal processing array, and a back-end drive output module. The front end employs a low-noise instrumentation amplifier with high common-mode rejection ratio and a multi-feedback bandpass filter to achieve high-fidelity extraction of weak temporal signals. The signal processing array uses a fully analog synapse-neuron nested primitive circuit, utilizing physical mechanisms such as pulse time-dependent plasticity to achieve decode-free adaptive feature encoding of non-stationary signals. This system uses a four-layer circuit board integration, resulting in extremely low single-channel static power consumption and an end-to-end signal processing delay of less than 5 ms. The system architecture completely eliminates the digital decoding delay of the von Neumann architecture, providing a highly reliable hardware-level solution for portable monitoring and closed-loop adaptive driving of weak signals.

The invention relates to marine antifouling conductive hydrogel as well as a preparation method and application thereof, and belongs to the technical field of biomedical engineering multifunctional material platforms and soft biological integrated electronics. The invention relates to a preparation method of a marine antifouling conductive hydrogel, which comprises the following steps: dissolving a zwitterionic monomer, acrylic acid N-hydroxysuccinimide ester and tannic acid in a polyaniline-polystyrolsulfon acid aqueous dispersion, adding a hydrophobic cross-linking agent, and magnetically stirring at room temperature to obtain a pre-gel solution; and adding an initiator into the pre-gel solution, uniformly stirring, and carrying out polymerization reaction to obtain the marine antifouling conductive hydrogel. A hydration-locked and electron-percolating interpenetrating network structure is constructed through a one-step in-situ gel method, antifouling activity, swelling resistance, cross-substrate wet adhesion and stable signal transmission are integrated together, a wide salinity window in seawater is further crossed, and the preparation method can be widely applied to intelligent marine bioelectronics.

The invention relates to chemical, electrochemical and non-covalently bioconjugation (functionalization) of proteins with catalytic properties. A functionalization method is disclosed using all organic solvents except dimethylformamide (DMF), and dimethyl sulfoxide (DMSO), and utilizing organic synthesis and non-covalent insertion methods. Furthermore, the invention encompasses the preparation of bioelectrodes designed for the detection of substances, including but not limited to glucose, lactose, galactose (as carbohydrates), dopamine, adrenaline (epinephrine), noradrenaline (norepinephrine), and serotonin (as neurotransmitters), L-glutamate, D- or L-amino acids, hydrogen peroxide, nicotine, cholesterol, ethanol, oxalate, lactate, and pyruvate in food products, as well as in human body fluids serving as real samples. Additionally, this invention extends to the utilization of bioelectrodes for monitoring chemical processes, including features and the chemical environment of neuron interfaces within the brain. The invention encompasses an electrochemical inhibitor testing system utilizing the aforementioned bioelectrodes, and the functionalized proteins as single-molecular protein-based memristors.

This invention relates to the field of flexible bioelectronics and skin-attached phototherapy technology, and discloses a temperature and pressure sensing flexible phototherapy patch and system for diabetic foot ulcers, including a flexible phototherapy patch, a control module, and a power supply module. The flexible phototherapy patch includes an adhesion layer, a pressure sensing layer, a light-emitting layer, a temperature sensing unit, a protective covering layer, and a flexible interface. The pressure sensing layer has a pressure sensing area and a light-transmitting area. The light-emitting layer is disposed at or corresponding to the light-transmitting area, allowing emitted red and near-infrared light to pass through the protective covering layer and irradiate the corresponding area of ​​the diabetic foot ulcer. The temperature sensing unit is disposed near the light-emitting layer to monitor local temperature rise. The control module receives pressure and temperature signals and adjusts the phototherapy output parameters according to the pressure signal, reducing the luminous power or stopping luminescence when the temperature exceeds a preset threshold. This invention combines skin-attached temperature and pressure monitoring, dual-band phototherapy output, and automatic over-temperature protection, making it suitable for continuous management and auxiliary phototherapy of diabetic foot ulcers.

An electrode includes a self-supporting porous structure of expanded graphite and an electrical connector. A method of making a self-supporting porous structure of expanded graphite, the method comprising the steps of: preparing a suspension of expanded graphite particles in a liquid; performing ultrasonic treatment on the graphite particle suspension by applying ultrasonic waves to obtain a homogeneous suspension; and filtering the homogeneous suspension under pressure to obtain an expanded porous structure that is at least partially dry and preferably substantially dry.

The application relates to a light-controlled active adaptive organic transistor, a preparation method and application, belongs to the field of organic bioelectronics, and is used for solving the technical problem that the design of integrated sensors and logic circuits causes the complexity of a sensor control circuit. The light-controlled active adaptive organic transistor comprises a semiconductor intermediate layer; the semiconductor intermediate layer comprises a light response layer and a carrier trapping layer; the light response layer is used for sensing a light signal and generating photo-generated carriers; the carrier trapping layer is used for trapping the photo-generated carriers; and the semiconductor intermediate layer is used for adjusting the decay time constant of output current of the adaptive organic transistor according to the brightness of the light signal. The technical scheme provided by the application can improve the applicability of an electronic device in simulating the vision of a biological body.

The invention discloses a wearable ultrasonic device for bladder capacity monitoring and a preparation method thereof, and relates to the technical field of medical instruments and bioelectronics, the device comprises a flexible ultrasonic sensor and a signal processing unit; the flexible ultrasonic sensor includes: a flexible substrate layer; the ultrasonic sensing array is arranged on the flexible substrate layer and is used for acquiring A-type ultrasonic echo signals of a bladder area; the acoustic matching layer is adhered to the ultrasonic sensing array; an acoustic lens structure is integrated in the acoustic matching layer; the flexible circuit module is electrically connected with the ultrasonic sensing array and is used for collecting and transmitting A-type ultrasonic echo signals; the signal processing unit is connected with the flexible circuit module, and is used for processing the A-type ultrasonic echo signal, performing interval classification on the bladder capacity based on a machine learning model, and determining a classification result; the whole wearable ultrasonic device is of a flexible attached structure, and the bladder capacity can be monitored more accurately.

This invention relates to a marine antifouling conductive hydrogel, its preparation method, and its applications, belonging to the fields of multifunctional materials platforms for biomedical engineering and soft bio-integrated electronics technology. A method for preparing a marine antifouling conductive hydrogel includes dissolving zwitterionic monomers, N-hydroxysuccinimide acrylate, and tannic acid in a polyaniline:polystyrene sulfonic acid aqueous dispersion, adding a hydrophobic crosslinking agent, and magnetically stirring at room temperature to obtain a pregel solution; adding an initiator to the pregel solution, stirring until homogeneous, and then carrying out a polymerization reaction to obtain the marine antifouling conductive hydrogel. This invention constructs a hydrated and electron-permeable interpenetrating network structure through a one-step in-situ gelation method, integrating antifouling activity, anti-swelling ability, cross-substrate wet adhesion, and stable signal transmission, and further spanning a wide salinity window in seawater, making it widely applicable in intelligent marine bioelectronics.

An exemplary system and method are disclosed for a wearable soft bioelectronic system configured with strain isolators that can isolate its sensor electrode or other sensors in proximity or in contact with the skin from temporary stretching and relative motion of the skin due to gross body movements, e.g., walking. The exemplary system employs hard-soft materials and an isolation structure that facilitates the use of a wearable sensor that can be placed on the surface of the skin and minimize motion artifacts in the acquired signals during physical motion by the wearer. The exemplary system can employ stretchable sensors in combination with the strain isolators.