37 results about "Bioelectronics" patented technology

The invention relates to the technical field of flexible bioelectronics and biomedical sensors, in particular to a biocompatible flexible carbon-based physiological electrode prepared through coaxial spinning and application of the biocompatible flexible carbon-based physiological electrode. The conductive core is formed by crosslinking graphene oxide, carbon nanotubes and the like; the buffer layer contains polyurethane and the like, and shape memory microspheres and antibacterial nano-silver are added; a biological interface layer contains chitosan and the like, and PEG-PE is grafted to reduce protein adsorption; the thickness ratio of the three layers is 1: (1.5-2): (0.5-1), and the thickness is 100-300 microns; the electrode has conductive, sensing and antibacterial functions, can load double enzymes for blood glucose monitoring, is strong in interlayer bonding, and is suitable for various biomedical scenes. By innovating the three-layer structure and the material design, high conductivity, high flexibility and excellent biocompatibility are achieved; multi-parameter monitoring and electrical stimulation treatment can be achieved, the anti-bending performance is good, the antibacterial and anticoagulant effects are good, the preparation process is controllable, and the application prospects in the fields of wearable equipment, implantation medical treatment and the like are wide.

The invention discloses a degradable, asymmetric-adhesion and non-swelling Janus hydrogel adhesive as well as a preparation method and application thereof, and belongs to the technical field of functional composite materials and preparation thereof. The problems that an existing Janus hydrogel cannot be degraded, is weak in adhesive force, adheres and is high in swelling are solved. Polyethylene glycol with double bonds, sodium alginate and chitosan are used for physical and covalent cross-linking, a degradable hydrogel substrate is constructed and then soaked in a phosphate buffer solution for swelling equilibrium, then a solution containing chitosan is used for preparing an adhesion coating, and the degradable and asymmetrically-adhered non-swelling Janus hydrogel adhesive is obtained. The adhesive can be applied to the biomedical fields of wound healing anti-adhesion, in-vivo degradability, intestinal repair and the like, and can also be used for adhesion of bioelectronics, epidermal physiological signal monitoring sensors, epidermal muscle fatigue monitoring sensors, rat subcutaneous muscle physiological signal monitoring sensors and muscle fatigue monitoring sensors.

The invention discloses a preparation method of high-toughness and high-conductivity deep eutectic gel. The preparation method comprises the following steps: (1) mixing PVA and PEDOT: PSS solutions with water to obtain a PVA / PP aqueous solution; (2) adding DBSA into the PVA / PP aqueous solution, and mixing to obtain a PVA / PP / DBSA aqueous solution; (3) performing freeze thawing cycle treatment on the PVA / PP / DBSA aqueous solution to obtain PVA / PP / DBSA hydrogel; (4) mixing the ChCl with the Gly to obtain ChCl / Gly DES (Diethylbenzene Sulfonate); and (5) carrying out solvent exchange on the PVA / PP / DBSA hydrogel and ChCl / Gly DES, so as to obtain the PVA / PP / DBSA / DES deep eutectic gel. The raw materials are cheap and easily available, and the preparation method is simple and feasible. The obtained deep eutectic gel has high strength, high toughness, high conductivity and weather-resistant stability, and can be applied to various flexible bioelectronics.

A conducting composition includes a topological polymer (e.g., a polyrotaxane polymer) and poly(3,4-ethylene-dioxy thiophene):polystyrene sulfonate (PEDOT:PSS). Devices may include a conducting layer including the conducting compositions, e.g., a device comprising a conducting layer, wherein the conducting layer includes a polyrotaxane polymer and a PEDOT:PSS array. The devices are useful in bioelectronics, including high-resolution electrophysiological monitoring of deformable tissues and localized neuromodulation for high-precision control of individual muscle activities.

A permanent fluidic magnet device includes a carrier fluid, and a plurality of non-Brownian nanomagnets disposed within the carrier fluid in a three-dimensional (3D) oriented and ramified magnetic (ORM) network structure. The permanent fluidic magnet device can be utilized in a system for detecting biomechanical signals from a subject, for example, cardiac signals, acoustic signals, etc. The permanent fluidic magnet device can also be implemented in a liquid robot system where the permanent fluidic magnet device can be actuated by an external magnetic field.

The utility model relates to the technical field of bioelectronics, in particular to a brain blood oxygen detection cap which comprises a cap body, a through hole is formed in the cap body, a detection head mounting seat is clamped in the through hole and comprises an inserting part and a mounting part which are connected, the inserting part penetrates through the through hole, and the mounting part is connected with the inserting part. The installation part is used for being connected with a light source or a detector used in cooperation with the brain blood oxygen detection cap, and the part between the insertion part and the installation part is arranged in the through hole and connected with a gasket in a clamped mode. The device can ensure that the light source and the detector always work perpendicular to the scalp to a certain extent, so that the detection result is not easy to have errors.

The present invention relates to a composition comprising a polymer of formula (I) and one or more compounds of formula (II) or formula (III), and to its use in the treatment of diseases (e.g., cancer, cardiovascular disease, infectious disease, or neurodegenerative disease). The polymer of formula (I) and one or more compounds of formula (II) or formula (III) have the following structure [Formula 1] Represented by JPEG2026513146000041.jpg60159, A, E, Z, Z', R1, R2, R3, R3', R4, R4', R5, R6, R7, R8, R9, R 10 n, m, a, y, and q are as defined in the specification.

The invention provides an artificial intelligence-based electrical stimulation method and system, and relates to the technical field of bioelectronics, and the method comprises the steps: firstly, synchronously collecting an electromyographic signal and a kinematics signal which are triggered by the electrical stimulation acting on a target muscle in a first period; then, analyzing and acquiring a first type of characteristic parameters representing a nerve recruitment dynamic state based on the electromyographic signal, and analyzing and acquiring a second type of characteristic parameters representing a muscle contraction mechanical state based on the kinematics signal; then, carrying out dynamic weight fusion on the first type of characteristic parameters and the second type of characteristic parameters to obtain a comprehensive muscle state index; then, according to the deviation between the comprehensive index and a preset target range, generating an adjusting instruction for adjusting the electrical stimulation parameters; and finally, adjusting the output electrical stimulation waveform parameters in real time according to the adjustment instruction in a second period following the adjustment instruction. Through multi-mode signal fusion and closed-loop feedback, self-adaptive accurate regulation and control of electrical stimulation parameters are realized.

In one aspect, the present disclosure provides nano and microstructures of conducting polymers which may be used in the treatment of neuron regeneration. In some embodiments, the microstructures may be a microcup or a nanogroove structure. The present disclosure also provides methods of preparing the conducting polymer coated microstructures and methods of using these compositions or structures.

The invention relates to a flexible brain-computer interface with high mechanical stability and a preparation method, and belongs to the field of bioelectronics. The interface comprises a flexible polyimide substrate; the composite metal microelectrode layer is formed on the flexible polyimide substrate through a vacuum evaporation process, the composite metal microelectrode layer comprises a chromium layer serving as a transition bonding layer and a gold layer serving as a conductive functional layer, the chromium layer is in direct contact with the flexible polyimide substrate so as to enhance the interface bonding strength, and the gold layer covers the chromium layer; and the photosensitive polyimide packaging layer is formed by patterning through a photoetching process and covers the composite metal microelectrode layer and part of the flexible polyimide substrate, and the photosensitive polyimide packaging layer is provided with a window which exposes part of a gold layer in the composite metal microelectrode layer to serve as an electrode contact site and an electrode bonding pad. The core problems that the interface bonding force between the existing titanium-based metal microelectrode and the flexible substrate is weak, and the mechanical-electrical stability is difficult to cooperate under long-term implantation are solved.

The invention relates to the technical field of biological conduction, in particular to a composite material and a rapid preparation method. The invention provides a bioelectronics-oriented novel flexible conductive composite material. The bioelectronics-oriented novel flexible conductive composite material is prepared by performing illumination molding on a mixed system. The preparation method comprises the following steps: dissolving polyether F127-diacrylate serving as an elastic network skeleton in a conductive polymer solution and uniformly doping a conductive polymer to prepare semi-interpenetrating double-network hydrogel; afterwards, excessive small molecules are removed through mild glacial acetic acid treatment, and chain segments are induced to be rearranged. The biological flexible conductive material prepared by the invention has excellent conductivity, mechanical property and biocompatibility, and a biological flexible electrode with good performance can be obtained by combining a 3D printing technology. According to the flexible electrode, the bottlenecks that an existing flexible electrode is low in conductivity, complex in packaging and limited in large-size printing are improved from a material system to a manufacturing process, and a universal and efficient new scheme is provided for implantable soft bioelectronics.

The present invention relates to a composition comprising a polymer of formula (I) and one or more compound of formula (II) or formula (III), and uses thereof in treating a disease, such as cancer, cardiovascular diseases, infections, or neurodegenerative diseases; wherein the polymer of formula (I) and the one or more compound of formula (II) or formula (III) are represented by the structures; and A, E, Z, Z′, R1, R2, R3, R3′, R4, R4′, R5, R6, R7, R8, R9, R10, n, m, a, y and q are as defined in the specification.

The present disclosure describes electrically stimulating biological systems using meshes, wherein the mesh comprises nanoscale wires and / or nanoelectronics. These may be embedded as a scaffold in biological structures, such as tissues, organoids, organs, organisms, and the like. These may be connectable to an external device to determine a property of the scaffold and / or to apply a stimulus to the biological structure. Certain embodiments are Al-driven systems designed for applications such as drug screening, stem cell therapy, or the like. In addition, some embodiments are directed to predictive models that can be used to predict and / or control the biological structure. For example, certain cells may be caused to mature more quickly, and / or the functionality of the biological structure may be enhanced or inhibited by using such models to apply suitable electrical stimuli to the biological structure, and / or portions of the biological structure.

The invention relates to a flexible wireless biological interface based on hydrogel and liquid metal and a preparation method, and belongs to the field of bioelectronics. The flexible wireless biological interface comprises a hydrogel substrate, a middle circuit layer and a hydrogel packaging layer, is of a sandwich structure and is applied to a cardiac pacemaker, and the manufacturing process comprises the steps that a hydrogel precursor solution is poured into a template to manufacture the hydrogel substrate and the packaging layer; preparing printing conductive ink; printing a liquid metal circuit pattern on the hydrogel substrate by using a template printing method; placing the components at the corresponding circuit positions, and dropwise adding liquid metal at the pin positions of the components; a nickel layer is pasted at the tail end of the circuit to serve as a stimulation output interface; and packaging a circuit by using the hydrogel packaging layer to prepare the flexible wireless cardiac pacemaker based on the hydrogel and the liquid metal. According to the invention, a liquid metal circuit is printed at one time by using a template printing technology, and a bioelectronic device can be manufactured on a hydrogel substrate.

Implantable bioelectronic semiconducting polymers including thiophene and / or selenophene are provided. Films including the polymers coated on substrates are further provided. Organic electrochemical transistors including channels including the polymers are further provided. Methods of preparing the polymers are further provided. Bioelectronic implant comprising polymers coated on substrates are further provided.

In one aspect, the present disclosure provides organic semiconductors (OSNTs) as well as high-performance electrochemical devices based on the present OSNTs for the production of micro and nano-scale actuators. The present OSNTs may be used in several applications, including movable and implantable interface devices, such as flexible neural microelectrodes. Also provided herein are flexible neural microelectrodes based on conjugated polymer actuators.

The application provides a cell electrotransformation instrument and a cell electrotransformation method, which can be applied to the field of bioelectronics and the like, and is used for solving the problem of low reliability of cell electrotransformation. The cell electrotransformation instrument comprises: a first electrode layer and a second electrode layer attached to different surfaces of an insulating layer respectively, the insulating layer has at least one hole, the hole and the surface to which the first electrode layer is attached and the surface to which the second electrode layer is attached form a cavity; a first friction layer is adjacent to the first electrode layer, and a second friction layer is adjacent to the second electrode layer; a rotating device comprises a fixed component and a rotating component, the first electrode layer, the second electrode layer and the insulating layer are fixed to the fixed component, the first friction layer and the second friction layer are fixed to the rotating component, the rotating component drives the first friction layer to rotate at a position with a first gap from the surface of the first electrode layer, and the rotating component drives the second friction layer to rotate at a position with a second gap from the surface of the second electrode layer.

A method of making a nanoporous membrane is constructed using an array of sacrificial nanopillars that print removable material on a substrate. After continuous deposition or even of covering layers with different properties, the sacrificial nanostructure is dissolved, and finally the nanoporous membrane with nanopores, channels and cavities designed with nanoscale sizes and geometrical shapes is formed. Thus, unprecedented unique functions are achieved in various technical fields (e.g., bioartificial organs, nanoelectronics, bioelectronics, molecular sensors and biomedical applications).

The invention discloses a flexible micro electrical stimulator capable of being wound and adhered to peripheral nerve tracts and a preparation method and application thereof, and relates to the technical field of crossing of neural engineering, bioelectronics and medical instruments. A first insulation layer, a first friction electrode layer, a middle isolation layer, a second friction electrode layer and a second insulation layer are assembled layer by layer; the first insulation layer and the second insulation layer are self-adhesion polyurethane layers, and the first friction electrode layer, the middle isolation layer and the second friction electrode layer are packaged in the first insulation layer and the second insulation layer; the first friction electrode layer is a gold foil, and the surface of the gold foil is electroplated with a PEDOT: PSS plating layer formed by a 3, 4-ethylenedioxythiophene monomer and polystyrene sulfonate; the second friction electrode layer is gold foil or aluminum foil. According to the invention, macro-scale contact-separation type friction power generation is realized through ultrasonic driving, and the device has good output performance, long-term stability and nerve stimulation effect.

The invention discloses a cell electric signal regulation and control membrane and a preparation method and application thereof, and relates to the technical field of bioelectronics, and the cell electric signal regulation and control membrane comprises a DNA framework used for being specifically combined with a cell membrane lipid layer, a DNA functionalized carbon nanotube and a complementary hairpin DNA group used for connecting the DNA framework and the DNA functionalized carbon nanotube. On one hand, molecular-level precision self-assembly of the carbon nanotubes guided by a DNA framework is realized through complementary base pairing of DNA, so that the carbon nanotubes are directionally arranged, and the disorder of modification of the carbon nanotubes is overcome; on the other hand, by means of the structural rigidity and cell membrane anchoring capacity of the DNA framework, the stability of anchoring the carbon nano tube on the cell membrane is improved, and damage to the integrity of the cell membrane is avoided as much as possible. Under the comprehensive action, the energy transfer efficiency and biocompatibility of the cell electric signal regulation and control membrane are improved.

The invention relates to ultraviolet-cured high-viscoelasticity ionic conductive hydrogel as well as a preparation method and application thereof, and belongs to the technical field of functional polymer materials and bioelectronics. According to the hydrogel, an ultraviolet light sensitive zwitterionic monomer (SBMA), a high-density cationic monomer (DMDMAC), a cross-linking agent (PEGDA) and a photoinitiator are selected, and under the ultraviolet light exposure condition, the photoinitiator is decomposed to generate active free radicals to trigger a cross-linking polymerization reaction. The hydrogel has a three-dimensional network structure, integrates softness, high stretchability, strong tissue adhesion and high conductivity, and has fracture tensile strain gt; the adhesive strength is gt; and the ionic conductivity can reach 2.24 S / m. The preparation process is simple, rapid in-situ forming of the hydrogel on the skin surface can be achieved, the flexible biological electrode prepared based on the hydrogel has low skin-electrode interface impedance, motion artifacts are effectively inhibited, and the flexible biological electrode is suitable for long-term, dynamic and high-signal-to-noise-ratio biological electric signal monitoring and has good application prospects. And good biocompatibility and wearing comfort are achieved.

The invention belongs to the field of nano materials and bioelectronics, and particularly relates to a preparation method of composite functionalized carbon nanotube fibers based on polypyrrole and nanogold. The method comprises the following steps: preparing carbon nanotube fibers; carrying out polypyrrole electrochemical polymerization functionalization on the carbon nanotube fiber to obtain a polypyrrole functionalized CNT fiber; the surface of polypyrrole is modified with gold nanoparticles, and the gold nanoparticle-polypyrrole composite functional fiber (as an electrode) is obtained. Or the method comprises the following steps: preparing nanofibers; preparing nanogold composite nanofibers; and preparing the polypyrrole / nanogold composite functionalized nanofiber (as an electrode). Polypyrrole (PPy) and nanogold (Au NPs) are adopted for composite modification, so that the electrochemical performance of the product is improved.

An electrode can comprise carbon black and one of polydimethylsiloxane (PDMS) or PVA, wherein the carbon black has a weight of between 10% and 50% of a weight of the PDMS or PVA. The electrode can be suitable for bioelectronics. A pattern of hydrogel can be deposited on the electrode for providing adhesion to a subject. The electrode can be used in wound treatment and / or monitoring devices or in various other bioelectronics applications.

An intrinsically stretchable organic electrochemical transistor with overall performance benchmarkable to a rigid device. The high performance was realized by reducing the oxygen level (PO2) of the stretchable substrates, which facilitates the de-doping of the conducting polymer channel. The high-performance intrinsically stretchable OECT is usable not only as a new device paradigm to impact the field of soft bioelectronics and promote the use of tissue-like stretchable OECTs in areas such as epidermal biosensing, soft neuromorphic computing and soft human-machine interfaces, but also to reveal a new critical parameter to alter the performance of stretchable conducting polymer-based devices.

The invention discloses MOF (Metal Organic Framework) enzyme-loaded gel as well as a preparation method and application thereof, and the preparation method comprises the following steps: when a gel precursor solution is prepared, adding enzyme-loaded MOF particles into the gel precursor solution, uniformly stirring, and incubating into gel to obtain the MOF enzyme-loaded gel. The enzyme-loaded MOF composite gel can be used for preparing a dopamine sensor, an epinephrine sensor or a noradrenaline sensor. According to the MOF enzyme-loaded gel disclosed by the invention, the size of the enzyme-loaded MOF is uniform, the metal organic framework around the enzyme can stabilize the structure of the enzyme to a great extent, the protein conformation of the enzyme is prevented from being changed, and the MOF enzyme-loaded gel has good biocompatibility, has enzymatic electron transfer and ion transfer capabilities, and can be widely applied to bioelectronics devices, bioelectronics devices, bioelectronics devices, bioelectronics devices, bioelectronics devices, bioelectronics devices, bioelectronics devices, bioelectronics devices, bioelectronics devices, bioelectronics devices, bioelectronics devices, bioelectronics devices and bioelectronics devices. A sensor, such as a dopamine sensor, a motion sensor; the preparation process is mild and efficient, and the material is environment-friendly and has good application prospects.

This invention relates to the field of fatigue monitoring technology, specifically to a real-time muscle fatigue monitoring method based on flexible bioelectronics. The method includes: S1: Using a flexible bioelectronic monitoring component attached to the target muscle group region, surface electromyography (EMG) signals, surface deformation signals, and contact load signals are simultaneously collected from the target muscle group region after the user initiates a target training movement, constructing a dynamic anchoring reference set for the target muscle group region; S2: Aligning and comparing subsequently collected signals with the dynamic anchoring reference set, calculating neural recruitment offset, deformation response delay, and load distribution offset, respectively, to construct a fatigue evolution feature set for the target muscle group region; S3: Performing continuous time-series analysis to identify fatigue propagation paths and compensatory takeover trends within the target muscle group region, determining the real-time fatigue level of the target muscle group region and the corresponding injury risk warning results. This invention enhances the forward-looking nature and intervention guidance value of fatigue assessment.

This invention relates to the field of flexible insulating materials technology, specifically a self-adhesive unidirectional hydrophilic silicone fiber membrane, its preparation method, and its applications. The preparation method provided by this invention, in order to match the high viscosity coefficients of liquid silicone and the sacrificial layer fluid material, designs a corresponding electrospinning platform for thermosetting polymer fiber forming, constructing an all-silicone flexible spun material framework; patterned exposure is performed on one side of the film using plasma with a template design, followed by self-assembly of a hydrophilic film at the exposed area, solidifying the hydrophilic groups on and inside the silicone fiber surface, thus achieving the unidirectional hydrophilic function and long-term stability of the final membrane material; the self-adhesive function under the all-silicone fiber framework is achieved by spinning core-shell structure fibers onto a base membrane; providing a new realization path for wearable bioelectronics and high-intensity exercise physiological detection substrates.

The present disclosure generally relates to nanoscale wires and nanoelectronics. Certain non-limiting embodiments are generally directed to implantation of stretchable electronics, e.g., in organisms, such as juveniles. For example, one aspect is generally directed to a stretchable component, which may form a part of an electrical circuit. The component may be connectable in certain embodiments to an external device, e.g., to determine a property of the component (e.g., an electrical property), and / or to apply a stimulus (e.g., an electrical stimulus) to a tissue in the organism. Other aspects are generally directed to methods of making or using such components, kits including such components, biological structures containing such components, or the like.

This invention belongs to the field of bioelectronics and edge computing technology, specifically a low-power, monolithically integrated adaptive electronic signal processing system. The system integrates a signal input interface, a two-stage low-noise amplification and filtering module, a neuromorphic signal processing array, and a back-end drive output module. The front end employs a low-noise instrumentation amplifier with high common-mode rejection ratio and a multi-feedback bandpass filter to achieve high-fidelity extraction of weak temporal signals. The signal processing array uses a fully analog synapse-neuron nested primitive circuit, utilizing physical mechanisms such as pulse time-dependent plasticity to achieve decode-free adaptive feature encoding of non-stationary signals. This system uses a four-layer circuit board integration, resulting in extremely low single-channel static power consumption and an end-to-end signal processing delay of less than 5 ms. The system architecture completely eliminates the digital decoding delay of the von Neumann architecture, providing a highly reliable hardware-level solution for portable monitoring and closed-loop adaptive driving of weak signals.

The invention relates to marine antifouling conductive hydrogel as well as a preparation method and application thereof, and belongs to the technical field of biomedical engineering multifunctional material platforms and soft biological integrated electronics. The invention relates to a preparation method of a marine antifouling conductive hydrogel, which comprises the following steps: dissolving a zwitterionic monomer, acrylic acid N-hydroxysuccinimide ester and tannic acid in a polyaniline-polystyrolsulfon acid aqueous dispersion, adding a hydrophobic cross-linking agent, and magnetically stirring at room temperature to obtain a pre-gel solution; and adding an initiator into the pre-gel solution, uniformly stirring, and carrying out polymerization reaction to obtain the marine antifouling conductive hydrogel. A hydration-locked and electron-percolating interpenetrating network structure is constructed through a one-step in-situ gel method, antifouling activity, swelling resistance, cross-substrate wet adhesion and stable signal transmission are integrated together, a wide salinity window in seawater is further crossed, and the preparation method can be widely applied to intelligent marine bioelectronics.