50 results about "Bioelectronics" patented technology

The invention discloses a preparation method of a micro-nano corrugated structure. The preparation method comprises the following steps of: (1) adding electrostatic spinning macromolecular solution into a syringe of a syringe pump, and fully filling the solution into a metal nozzle connected with the anode of a high pressure generator; (2) placing a metal cathode collecting plate connected with the ground electrode of the high pressure generator below the metal nozzle of the syringe, placing a flexible base material on the collecting plate, controlling the macromolecular solution to flow out at certain velocity, and electrifying the macromolecular solution to form jet flow; and (3) moving the metal collecting plate so that the jet flow falls on the flexible base material, namely the corrugated structure is formed on the whole base material. The invention also discloses the micro-nano corrugated structure prepared by using the method, a device for implementing the method and application of the method. When the elastic rubber base material stretches, the formed nano fiber graph can produce great deformation together with the elastic rubber base material and does not break, so that effective interconnection and stretching of flexible electrons are realized, and the invention has broad application prospect on the aspects of electronic skin, artificial muscles, bioelectronics and the like.

The present invention relates to an organic semiconductor thin film suitably employed in electronics, photonics, bioelectronics, or the like, and a method for forming the same. The present invention further relates to a solution for an organic semiconductor used to form the organic semiconductor thin film and an organic semiconductor device using the organic semiconductor thin film. The transistor of the present invention is manufactured by forming sequentially a gate electrode (2), an insulator layer (3), a source electrode and drain electrode (4, 4) on a glass substrate (5), applying thereto a 0.05% (by mass) solution of pentacene in o-dichlorobenzene and drying the solution to form an organic semiconductor thin film (1). The present invention provides a transistor with superior electronic characteristics because the organic semiconductor thin film (1), which can be formed easily at low cost, is almost free of defects.

The present invention generally relates to nanobioelectronics and, in some cases, to circuits comprising nanoelectronic elements, such as nanotubes and / or nanowires, and biological components, such as neurons. In one aspect, cells, such as neurons, are positioned in electrical communication with one or more nanoscale wires. The nanoscale wires may be used to stimulate the cells, and / or determine an electrical condition of the cells. More than one nanoscale wire may be positioned in electrical communication with the cell, for example, in distinct regions of the cell. However, the nanoscale wires may be positioned such that they are relatively close together, for example, spaced apart by no more than about 200 nm. The nanoscale wires may be disposed on a substrate, for example, between electrodes, and the cells may be adhered to the substrate, for example, using cell adhesion factors such as polylysine. Also provided in other aspects of the invention are methods for making and using such devices, kits for using the same, and the like.

The invention discloses a multi-parameter electrochemical immunosensor based on an electrode array and a preparation method thereof, relating to the biosensor technology and the bioelectronics technology. The sensor is integrated with the electrode array, a counter electrode, an electrochemical reference electrode, a lead and an interface on a substrate. According to the sensor, the micro electro mechanical system (MEMS) technology is adopted to process and prepare the basic electrode array, silver and silver chloride (Ag / AgCl) are used for modifying the counter electrode and the electrochemical reference electrode, and electric media bodies, porous shielding films, nano materials, antibodies and the like are fixed on a detection electrode to form a multi-parameter detection system. The sensor has the characteristics of good stability and convenience for use, and can simultaneously detect a plurality of lung cancer biomarkers, so as to facilitate clinical application.

Systems, methods, and apparatuses monitor mammal conditions, report condition changes, and provide neurocode-based treatment in response to condition changes. A mammal implantable controller includes modules to monitor, wirelessly communicate to external computers, and administer treatment received from a remote computer based on monitoring of changes in mammal condition as analyzed by the remote computer. External computers can be provided in the form of a mobile device (e.g., smartphone / tablet), resident treatment pods, and treatment servers. Treatment can be provided to change biological function or trigger cell death in cancer cells.

The invention provides a method for efficiently making high precision nanometer holes and nanometer hole arrays by utilizing focusing electronic beams, comprising the following steps of: irradiating polymethyl methacrylate nanometer fibers for 1-60s by using focusing electronic beams with the strength of 1*10-1*10e / nms to obtain the nanometer holes with the aperture of 0.5nm-10nm under the conditions of the vacuum of 1*10-1*10Torr and the working voltage of 100kV-200kV; and deflecting electronic beams for continuing to irradiate the polymethyl methacrylate nanometer fibers to obtain the nanometer hole arrays. The invention can precisely control the size of the nanometer holes through the strength and the irradiation time of the electronic beams (the precision can reach up to 0.1 nanometer), and control the deflection of the electronic beams through static electricity so as to control the period of the nanometer holes; and the period of the nanometer hole arrays can be controlled between 1nm and 20nm. The method is mainly applied to the fields such as DNA sequence detection, biosensors, nanometer bioelectronics, photonic crystal and the like.

The present invention covers novel approaches to the differential amplification of an input signal. Embodiments of the present invention have precise gain, swing to within micro-volts (μV) of ground, and have high CMRR without the need for precision resistors or tuned potentiometers. Embodiments of the present invention are particularly suited for the amplification of an instrumentation signal for delivery to an analog-to-digital converter. Examples of such signals include the product of a strain-gauge front end, a temperature sensor front end, and certain devices for bioelectronics detection. Embodiments of the present invention which are systems for amplification of a differential input signal can comprise a differential input stage transconducing a differential voltage input signal into a single-ended intermediate current signal using a follower transconductance amplifier, and a single-ended output stage comprising an amplifier producing an output voltage across a resistor network that forms a negative feedback network of the amplifier.

The invention discloses a preparation method for a field effect transistor. The field effect transistor comprises a substrate, a gate electrode, a dielectric layer, a semiconductor layer, a source electrode and a drain electrode, and a packaging layer from the bottom up in sequence. Based on the adhesive characteristic of lac, the dielectric material can be physically peeled off so as to form the stable dielectric layer having a thickness equal to that of several molecules, so that a solution method preparation step of the dielectric layer is omitted, the usage of poisonous reagents is effectively eliminated, and the stability is improved; meanwhile, the lac is used as the substrate and the packaging layer; due to the characteristics of high compactness, ultraviolet resistance, radiation resistance and the like of the lac, corrosion to the whole device by water and oxygen can be blocked, and interference on the device by ultraviolet and electromagnetic radiation can be prevented, so that the stability of the overall device is improved and the service life of the overall device is prolonged; the field effect transistor adopts the peelable dielectric layer and the biological material as the substrate and the packaging layer, so that the field effect transistor is easier to prepare and lower in cost; and in addition, the application range of the field effect transistor is expanded, so that the field effect transistor can be applicable to the fields of wearable equipment and bioelectronics, and is suitable for large-scale mass production.

Described herein is a materials system for electronic device substrates made of nanocellulose and nanocellulose composites that can be transferred to biological tissue while carrying electronic devices. These electronic device substrates are suitable for thin-film electronic devices to adhere and conform to a biological surface, such as human, plant or animal tissue.

The invention includes a bioelectronic interface comprising a self-assembling unit, wherein the self-assembling unit comprises a variant GPCR fusion protein bound to an S-layer fusion protein. The invention also encompasses a biosensor or device comprising the bioelectronic interface and methods of screening for a ligand of a GPCR.

The invention provides a method for reducing and adsorbing uranium in wastewater by using nano-synthetic material combined with self electricity-generating microorganisms under illumination conditions. The method uses nano-zero valent iron (nZVI), a high-electroconductivity nano carbon material (C), and electricity-generating microorganisms as raw materials, uses the high reduction activity of thenZVI, the photocatalytic effect of an nZVI oxidation product combined with the C, and the characteristics of producing bioelectronics of the electricity-generating microorganisms for efficient reduction and adsorption treatment of the uranium-containing wastewater. The method comprises the following specific steps: (1) synthesizing a nano material (nZVI-CNT); (2) loading the nZVI-CNT on the surfaces of the microorganisms to obtain bio-nZVI-CNT; (3) placing the bio-nZVI-CNT into the uranium-containing wastewater with a concentration of <=50 mg / L under illumination, adjusting the pH to 4-6, andperforming uniform mixing under stirring; (4) performing solid-liquid separation after 2 hours; and (5) performing desorption to recover the uranium, and recycling the bio-nZVI-CNT. The method can reduce the uranium content in the uranium-containing wastewater with the concentration of <=50 mg / L by 96% or more, and the adsorption capacity is as high as 436.4 mg / g; and the method is simple and convenient to operate, has high removal efficiency and short removal time, and has good environmental, social and economic benefits.

The invention discloses a near-room temperature preparation process of a high-performance thin film transistor and application. The process comprises the following steps: 1, placing a conductive substrate into an atomic layer deposition reaction chamber and vacuumizing; 2, depositing and growing Al2O3 at 20-40 DEG C; 3, put that device obtained in the step 2 into a magnetron sputter deposition cavity and vacuumizing; 4, grow an IGZO channel layer under the temperature of 20 to 40 DEG C; 5, carrying out ultraviolet exposure on the device obtained in the step 4, and etching to form a channel; 6,perform second photolithography, evaporating a source-drain electrode, remove photoresist, and obtaining a bottom gate type high-performance thin film transistor without annealing treatment. The invention provides a near-room temperature preparation process of a high-performance thin film transistor, and the thin film transistor has the responsiveness to light of different wavelengths and can beused in the fields of flexible electronics, photoelectric detection, bioelectronics and the like.

The invention relates to hydrated ionic liquid gel and a preparation method and application thereof. The hydrated ionic liquid gel is prepared through the following method that when gel is prepared through enzymatic gelling, hydrated ionic liquid serves as a solvent, contains organic substances of anions and cations and follows the Huffman ion effect, and the hydrated ionic liquid gel is preparedthrough a hydrothermal method. The hydrogel can be used as a protective agent to stabilize a hydration layer of an enzyme, and has good biocompatibility. Compared with the prior art, the preparation process is mild and efficient, materials are environmentally friendly, and the prepared bioelectronics platform has enzymatic electron transfer and ion transfer capacity and can be widely applied to bioelectronics devices such as glucose sensors, motion sensors and energy storage devices.

The present invention is directed to a versatile and high performance zwitterionic CP platform, which integrates all desired functions into one material. This zwitterionic CP consists of the conducting backbone and multifunctional zwitterionic side chains. Non-conducting zwitterionic materials gain electronic conductivity through the conducting backbone and CPs obtain excellent biocompatibility, sensitivity to environmental stimuli and controllable antifouling properties via multifunctional zwitterionic side chains. Unique properties from two distinct materials (conducting materials and zwitterionic materials) are integrated into one material without sacrificing any properties. This platform can potentially be adapted for a range of applications (e.g. bioelectronics, tissue engineering, wound healing, robotic prostheses, biofuel cell, etc.), which all require high performance conducting materials with excellent antifouling / biocompatibility at complex biointerfaces. This conducting material platform will significantly advance the development of conducting polymers in the field of biomedicine and biotechnology.

Methods and systems for treating pancreatic cancer. A signal associated with pancreatic cancer in a body can be detected and recorded, and then reprogrammed to generate a confounding treatment signal with respect to the pancreatic cancer. The confounding treatment signal can be aimed at the pancreatic cancer in the body to shut down pancreatic cancer cells associated with said pancreatic cancer. The treatment signals can be provided as tiny encoded signals powered by ultra-low voltage approximated to the power level of the actual live pancreatic cancerous cell targets. An audio-light-optic system can seek out spreading pancreatic cancer cells that have moved onto nerves and blood vessels and the nearby organs, which include, for example, the liver, stomach, gall-bladder, spleen, and duodenum. Once the aberrant pancreatic cells are identified, the confounding treatment signals can be applied to destroy them.

The invention relates to the field of bioelectronics and discloses an addressable semiconductor disease chip and a manufacturing method thereof. The semiconductor disease chip comprises a semiconductor chip and detection wells. The invention also relates to a surface functionalization method and a detection method. The semiconductor chip is characterized by comprising at least one sensor array and a detection well array above the sensors correspondingly, wherein the sensors are connected through a circuit; the positions of all the wells are confirmed and the wells are not interfered from each other.Detection indexes for specific diseases are fixed in the wells; target molecules enter into the detection wells and can have special reactions; corresponding enzymes can catalyze substrates for changing ion concentration; the sensors can sense the pH change in the detection wells so as to generate an electric signal. One well at most is corresponding to one index or one disease or a plurality of wells are corresponding to different indexes of one disease, and thus the multi-index simultaneous detection can be realized. The position of strong signal is corresponding to the well with active reaction, namely, to the to-be-detected index in the well.

A thin film with multiple binding functionality can be prepared on an electrode surface via consecutive electroreduction of two or more aryl-onium salts with different functional groups. This versatile and simple method for forming multifunctional surfaces provides an effective means for immobilization of diverse molecules at close proximities. The multifunctional thin film has applications in bioelectronics, molecular electronics, clinical diagnostics, and chemical and biological sensing.

A semiconductor sensor for sensing the variation of the diameter of pore on human body is a doped semiconductor chip able to be pasted on the skin of human body. When it is serially connected in a DC loop with a constant-current source, its two power supply inputs are just the signal outputs. If said loop has a constant-voltage source, the current flowing through said loop is the output signal to be detected.

The invention discloses a generation method of frequency and shape waveforms used for human impedance measuring in the field of bioelectronics measuring. The generation method includes: writing clock frequency division coefficient, frequency division clock cycle period coefficient K and waveform data into a nonvolatile memory through a burning interface; reading out the clock frequency division coefficient and the frequency division clock cycle period coefficient from the nonvolatile memory; using a frequency division clock to read the waveform data from the nonvolatile memory, and outputting the data according to certain rules. By controlling the clock frequency division coefficient and frequency division clock cycle period, frequency and shape of generated waveforms can be adjusted to acquire better testing results of human impedance.

In one or more embodiments, the present invention provides a method of forming compact, flexible, stable and biocompatible conducting polymer coating for bioelectronics devices. In one or more embodiments, the present invention relates to a novel method of synthesizing a sulfobetaine-functionalized conjugated polymer platform using 3,4-ethylenedioxythiophene (EDOT) as the conducting backbone (SBEDOT). This SBEDOT monomer is highly water-soluble and can be directly polymerized to form a densely packed film / coating on conductive or semi-conductive surfaces through electro-polymerization in a 100% aqueous solution without the need for organic solvents or surfactants. These polySBEDOT (PSBEDOT) coated surfaces have been shown to have electro-switchable antimicrobial / antifouling properties and excellent electrically conducting properties, which minimize infection, increase biocompatibility, and improve the performance of bioelectronics.

The invention belongs to the field of nanotechnology, relates to a standard measurement method for nano-drug quantum dots, nano electronics and quantum information and quantum biology, and in particular relates to a method for forming a room-temperature superconducting (damping loss or zero conductance) quantum bit network from a self-assembly redox nano-drug soft-condensed semiconductor nano crystal (quantum dots) array structure. The method provided by the invention can be applied to the new fields of developing bioelectronics, a biosensor, a quantum device, quantum biology standard measurement technology, a photoelectric information function advanced material, a biological quantum dot array diagnosis tool with a target recognition function, a nano bioelectrochemical sensor and a graded sequential nano structure. The application range involves the development of a biological photoelectric sensing information material, a biological single-electrode transistor, a built-in nano biological photoelectric sensor and a new advanced medical diagnosis tool.

The present invention is directed to a versatile and high performance zwitterionic CP platform, which integrates all desired functions into one material. This zwitterionic CP consists of the conducting backbone and multifunctional zwitterionic side chains. Non-conducting zwitterionic materials gain electronic conductivity through the conducting backbone and CPs obtain excellent biocompatibility, sensitivity to environmental stimuli and controllable antifouling properties via multifunctional zwitterionic side chains. Unique properties from two distinct materials (conducting materials and zwitterionic materials) are integrated into one material without sacrificing any properties. This platform can potentially be adapted for a range of applications (e.g. bioelectronics, tissue engineering, wound healing, robotic prostheses, biofuel cell, etc.), which all require high performance conducting materials with excellent antifouling / biocompatibility at complex biointerfaces. This conducting material platform will significantly advance the development of conducting polymers in the field of biomedicine and biotechnology.

This invention is directed toward a bioelectronic cell gated nanodevice. The bioelectronic cell gated nanodevice comprises a plurality of bioelectric cells deposited on a fiber of a nanodevice. The bioelectronic cells of the nanodevice act as a gate, allowing current to be transmitted when the bioelectronic cells are exposed to an actuating chemical. The present invention also provides methods for constructing such a device.

The invention belongs to the field of nanometer technology, and relates to nanomedicine quantum dots, nanoelectronics, quantum information and quantum biological standard measurement methods. It specifically relates to a method for self-assembling redox (Redox) nanomedicine soft condensed semiconductor nanocrystal (quantum dot) array structure to form a room temperature superconducting (damping disappearance or zero conductance) qubit network method. The invention can be used to develop bioelectronics, biosensors, quantum devices, quantum biological standard measurement technology, advanced materials with photoelectric information functions, biological quantum dot array diagnostic tools with target recognition functions, nanobioelectrochemical sensors and hierarchically ordered nanostructures New Field. Its application scope involves the development of bio-photoelectric sensing information materials, biological single-electron transistors, built-in nano-bio-photoelectric sensors, and new tools for advanced medical diagnosis.

The invention relates to an air-lift type anaerobic bioreactor, and belongs to the technical field of bioelectronics equipment. The reactor comprises a reaction tank, a gas inlet pipe, a gas ejector pipe, a separator and a nitrogen tank. The separator is located at the bottom inside the reaction tank. The bottom of the reaction tank is provided with a sewage discharge outlet. The gas inlet pipe penetrates through the top of the reaction tank to extent to the bottom of the reaction tank. The gas ejector pipe is connected with the bottom end of the gas inlet pipe. The gas ejector pipe is horizontally arranged at the bottom of the reaction tank. A plurality of gas nozzles are uniformly formed in the gas ejector pipe. The middle of the top of the reaction tank is provided with an exhaust opening. A plurality of staggered baffles are further arranged inside the reaction tank. One edges of the baffles are fixedly connected to the reaction tank. According to the air-lift type anaerobic bioreactor, the staggered baffles are adopted for limiting the gas flowing direction, so that a solution inside the tank is stirred, and the stirring effect is generated; meanwhile, due to the staggered baffles, the gas speed is lowered, and liquid with the high viscosity can be sufficiently stirred.

A diameter sensor of human hair trichopore is a doped semiconductor chip which is serially connected in a DC circuit and can be stably pasted on human skin. If a constant current source is used in said DC circuit, the two power inputs of said semiconductor chip are signal outputs. If a constant voltage source is used, the current flowing through said semiconductor chip is just the output signal. Its signal processing circuit is composed of small signal amplifier, logrithmic operation circuit and extraction operating circuit.

An exemplary embodiment of the present disclosure provides a method of determining stress levels in a user comprising: receiving galvanic skin response (GSR) measurements by a wearable sensor on the user over a period of time; receiving temperature measurements by the wearable sensor on the user over the period of time; determining changes in the temperature over a predetermined threshold in the temperature measurements over the period of time; calibrating the GSR measurements based on the determined changes in temperature over the predetermined threshold; calculating a stress level of the user based on the calibrated GSR measurements; and generating an output indicative of the calculated stress level.