Hydrated ionic liquid gel and preparation method and application thereof

A technology of hydrated ions and lyogels, which is applied in the field of gel materials, can solve the problems of enzyme denaturation, poor gel storage stability, inability to achieve effective combination of ion conduction and enzymatic electron transfer, and achieve stable ion conduction performance and protection No denaturation, guaranteed activity and stability

Inactive Publication Date: 2021-01-12
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The purpose of the present invention is to provide a hydrated ionic liquid gel and its preparation method in order to solve the problem that the enzyme is easily denatured in the gel and cannot realize the effective combination of ion conduction and enzymatic electron transfer and the problem of poor storage stability of the gel and application

Method used

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  • Hydrated ionic liquid gel and preparation method and application thereof
  • Hydrated ionic liquid gel and preparation method and application thereof
  • Hydrated ionic liquid gel and preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0052] Add 200 μL acrylic acid (AA), 10 mg double bond chondroitin sulfate (CSMA), 10 mg N-hydroxysuccinimide (NHS), 50 μL glucose solution (40 mmol / L) into 500 μL hydrated ionic liquid (containing 1-ethyl -3-Methylimidazole ethyl sulfate salt 100 μL), stir evenly until the solution becomes homogeneous and transparent. Then, add dilute sodium hydroxide solution dropwise to adjust the pH value of the solution to 4-5, then add hydrated ionic liquid (containing 20% ​​mass fraction of 1-ethyl-3-methylimidazole ethyl sulfate salt) to constant volume to 900 μL; finally, add 100 μL of glucose oxidase solution (10 mg / mL) to obtain a precursor solution. Put the precursor solution in a constant temperature water bath and incubate at 37°C for 60min. Finally, a hydrated ionic liquid gel bioelectronics platform is obtained. Its compressive strength is 1.5MPa, which can withstand 95% of its own deformation; its tensile strength is 56.5KPa, and its maximum tensile deformation is 1300%; its...

Embodiment 2

[0068] Add 200 μL acrylic acid (AA), 10 mg double bond chondroitin sulfate (CSMA), 10 mg N-hydroxysuccinimide (NHS), 50 μL glucose solution (40 mmol / L) into 500 μL hydrated ionic liquid (containing 1-ethyl -3-Methylimidazole ethyl sulfate salt 200 μL), stir evenly until the solution becomes homogeneous and transparent. Then, add dilute sodium hydroxide solution dropwise to adjust the pH value of the solution to 4-5, then add hydrated ionic liquid (containing 40% 1-ethyl-3-methylimidazole ethyl sulfate salt) to constant volume to 900 μL. Finally, add 100 μL of glucose oxidase solution (10 mg / mL) to obtain a precursor solution. Put the precursor solution in a constant temperature water bath and incubate at 37°C for 60min. Finally, a hydrated ionic liquid gel bioelectronics platform is obtained.

Embodiment 3

[0070] Add 200 μL acrylic acid (AA), 10 mg double bond chondroitin sulfate (CSMA), 10 mg N-hydroxysuccinimide (NHS), 50 μL glucose solution (40 mmol / L) into 500 μL hydrated ionic liquid (containing 1-ethyl -3-Methylimidazole ethyl sulfate salt 300 μL), stir evenly until the solution becomes uniform and transparent. Then, add dilute sodium hydroxide solution dropwise to adjust the pH value of the solution to 4-5, then add hydrated ionic liquid (containing 60% 1-ethyl-3-methylimidazole ethyl sulfate salt) to constant volume to 900 μL. Finally, add 100 μL of glucose oxidase solution (10 mg / mL) to obtain a precursor solution. Put the precursor solution in a constant temperature water bath and incubate at 37°C for 60min. Finally, a hydrated ionic liquid gel bioelectronics platform is obtained.

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Abstract

The invention relates to hydrated ionic liquid gel and a preparation method and application thereof. The hydrated ionic liquid gel is prepared through the following method that when gel is prepared through enzymatic gelling, hydrated ionic liquid serves as a solvent, contains organic substances of anions and cations and follows the Huffman ion effect, and the hydrated ionic liquid gel is preparedthrough a hydrothermal method. The hydrogel can be used as a protective agent to stabilize a hydration layer of an enzyme, and has good biocompatibility. Compared with the prior art, the preparation process is mild and efficient, materials are environmentally friendly, and the prepared bioelectronics platform has enzymatic electron transfer and ion transfer capacity and can be widely applied to bioelectronics devices such as glucose sensors, motion sensors and energy storage devices.

Description

technical field [0001] The invention relates to a gel material, in particular to a hydrated ionic liquid gel and its preparation and application. Background technique [0002] Bioelectronics is a rapidly developing and popular interdisciplinary subject. Its main research purpose is to transform the identification and transmission of biological signals into electronic signals that can be recognized by artificial machines. The difficulty in the research of bioelectronics at this stage is the incompatibility of the interface between biological tissues and artificial devices. As we all know, the electrical signal transmission of organisms in nature mainly conducts electricity through ions, while artificial electronic materials mainly conduct electricity through electrons. Moreover, most biological tissues are soft and wet materials, while artificial electronic materials are mainly hard and inflexible materials. Therefore, the essential difference between the two makes the inte...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F251/00C08F220/06C08F220/56C08F220/58C08F222/38C08F222/20C08J3/075C08L51/02C08L33/26
CPCC08F220/56C08F251/00C08J3/075C08J2333/26C08J2351/02C08F220/06C08F220/58C08F222/385C08F222/1063
Inventor 尚英辉王启刚
Owner TONGJI UNIV
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