Load-controllable hydrophobic pesticide sustained-release microcapsule and preparation method thereof

A technology for slow-release microcapsules and hydrophobic pesticides, which is applied in the fields of botanical equipment and methods, animal repellents, biocides, etc., can solve the problems of limited types of hydrophobic pesticides and limited drug loading, and achieve controllable drug loading. , The effect of wide application area and mild conditions

Active Publication Date: 2013-02-27
ZHONGKAI UNIV OF AGRI & ENG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Limited by the type of polymer material of the capsule wall, the types of hydrophobic pesticides loaded by this method are limited and the amount of drug loading is limited

Method used

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  • Load-controllable hydrophobic pesticide sustained-release microcapsule and preparation method thereof
  • Load-controllable hydrophobic pesticide sustained-release microcapsule and preparation method thereof
  • Load-controllable hydrophobic pesticide sustained-release microcapsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] In a 500ml four-neck bottle equipped with a thermometer, a stirring device and a condenser, add 180ml of ethyl acetate and raise the temperature. After the temperature in the bottle rises to 75°C, start to drop the mixed solution of acrylate monomer and initiator. Its composition is 70g of methyl methacrylate, 10g of methyl acrylate, 10g of butyl methacrylate, 8g of hydroxyethyl acrylate, 2g of acrylic acid and 0.6g of azobisisobutyronitrile, which is dropped within 3 hours. After the monomers were added dropwise, 0.1 g of azobisisobutyronitrile was added, the temperature was lowered after continuing to keep warm for 2 hours, and a hydroxyacrylate solution with a mass fraction of 35% was obtained.

Embodiment 2

[0039] In a 500ml four-necked bottle equipped with a thermometer, a stirring device and a condenser, add 100ml of butyl acetate and raise the temperature. After the temperature in the bottle rises to 90°C, start to drop the mixed solution of acrylate monomer and initiator. Its composition is methyl methacrylate 60g, styrene 20g, methyl acrylate 5g, butyl acrylate 5g, hydroxyethyl methacrylate 10g, methacrylic acid 4g and benzoyl peroxide 0.6g, drop in 3 hours use up. After the monomers were added dropwise, 0.09 g of benzoyl peroxide was added, and the temperature was lowered after continuing to keep warm for 2 hours to obtain a hydroxyacrylate solution with a mass fraction of 50%.

Embodiment 3

[0041] In a 500ml four-neck bottle equipped with a thermometer, a stirring device and a condenser, add 100ml of propylene glycol methyl ether acetate and raise the temperature. After the temperature in the bottle rises to 100°C, start to add the mixture of acrylate monomer and initiator dropwise. Solution, its composition is methyl methacrylate 70g, styrene 15g, butyl methacrylate 5g, hydroxyethyl methacrylate 10g, acrylic acid 4g and benzoyl peroxide 0.8g, dripped in 3 hours. After the monomer was added dropwise, 0.1 g of benzoyl peroxide was added, and the temperature was lowered after continuing to keep warm for 2 hours to obtain a hydroxyacrylate solution with a mass fraction of 50%.

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Abstract

The invention discloses a load-controllable hydrophobic pesticide sustained-release microcapsule and a preparation method and applications thereof. The microcapsule comprises a core material and a wall material, wherein the wall material is prepared from hydroxyl acrylate polymers with carboxyl groups under the crosslinking of divalent metal ions, and the hydrophobic pesticide core material is fed into the microcapsule. The preparation method comprises the following steps of: firstly, dissolving a hydrophobic pesticide and hydroxyl acrylates so as to form a polymer solution; then, adding water into the polymer solution, and carrying out high-speed stirring on the obtained mixture so as to form an emulsion; and finally, adding a divalent metal ion solution into the emulsion so as to obtain a granular condensation product, and filtering and drying the obtained product. The size of the microcapsule can be flexibly controlled at 0.5-50 microns, and the mass of the core material accounts for 5-70% of the total weight of a sustained-release capsule. According to the sustained-release capsule disclosed by the invention, through adjusting parameters such as the compositions of the wall material, the solvent types, the ratio of the core material to the wall material, and the like, the effective loading of one or more hydrophobic pesticides can be realized, and the obtained drug-carrying microcapsule has an advantage that the drug-carrying capacity and the sustained-release performance are controllable, therefore, the preparation method is applicable to the preparation of multiple hydrophobic pesticide sustained-release microcapsules.

Description

technical field [0001] The invention belongs to the field of pesticide formulation processing, and particularly relates to a controllable loading hydrophobic pesticide slow-release microcapsule and a preparation method thereof, which are suitable for efficient and controllable loading of more than one hydrophobic pesticide. Background technique [0002] Pesticide control of crop diseases, insect pests and weeds is a necessary condition for modern large-scale agriculture and commercial agriculture. my country is now the second largest producer of pesticides in the world. At present, the main dosage form of hydrophobic pesticides is emulsifiable concentrate, which contains a large amount of organic solvents, wastes resources and pollutes the environment, has poor dispersion and low effective utilization rate, resulting in a large amount of pesticide residues. The utilization rate of conventional pesticide formulations is only 20% to 30%, and there are problems such as rapid re...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N25/28A01N57/16A01N53/08A01N51/00A01N43/90
Inventor 周新华罗璋肖文清龚圣刘其海崔英德
Owner ZHONGKAI UNIV OF AGRI & ENG
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