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Novel mecobalamin sustained-release capsule and preparation method thereof

A technology for sustained-release capsules and methylcobalamin, which is applied in pharmaceutical formulations, medical preparations with inactive ingredients, and medical preparations containing active ingredients, etc., to achieve the effects of easy control, low investment and low cost

Inactive Publication Date: 2011-11-09
广州艾格生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Vitamin B 12 and steroid hormone therapy for PFP can achieve certain curative effect, but some patients still have sequelae of varying degrees

Method used

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  • Novel mecobalamin sustained-release capsule and preparation method thereof
  • Novel mecobalamin sustained-release capsule and preparation method thereof
  • Novel mecobalamin sustained-release capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Embodiment 1 (this sustained-release capsule is prepared under lucifuge condition)

[0037]

[0038]

[0039] (1) Adding povidone and methylcobalamin to 95% ethanol under the condition of avoiding light, stirring and dissolving into a transparent and clear solution;

[0040] (2) Under the condition of avoiding light, use an atomizing spray gun to spray the above-mentioned solution onto a blank pellet core with a diameter of 75-150 μm, and dry it to prepare methylcobalamin drug-containing pellets.

[0041] (3) Dissolve Eudragit and EC with an appropriate amount of solvent to dissolve the slow-release material, and at the same time, add triethyl citrate, talcum powder, magnesium stearate or colloidal silicon dioxide into an appropriate amount of solvent to form a suspension liquid, and then add this suspension to the above-mentioned slow-release material solution under stirring and mix evenly to make a slow-release coating solution;

[0042] (4) Use an atomizing sp...

Embodiment 2

[0044] Embodiment 2 (this sustained-release capsule is prepared under lucifuge condition)

[0045]

[0046] (1) Povidone and methylcobalamin are added in 95% ethanol under the condition of avoiding light, stirring and dissolving into a transparent and clear solution;

[0047] (2) Under the condition of avoiding light, use an atomizing spray gun to spray the above-mentioned solution onto a blank pellet core with a diameter of 150-300 μm, and dry it to prepare a drug-containing methylcobalamin pellet.

[0048](3) Dissolve Eudragit and EC with an appropriate amount of solvent to dissolve the slow-release material, and at the same time, add triethyl citrate, talcum powder, magnesium stearate or colloidal silicon dioxide into an appropriate amount of solvent to form a suspension liquid, and then add this suspension to the above-mentioned slow-release material solution under stirring and mix evenly to make a slow-release coating solution;

[0049] (4) Use an atomizing spray gun ...

Embodiment 3

[0051] Embodiment 3 (this sustained-release capsule is prepared under lucifuge condition)

[0052]

[0053] (1) Adding povidone and methylcobalamin to 95% ethanol under the condition of avoiding light, stirring and dissolving into a transparent and clear solution;

[0054] (2) Under the condition of avoiding light, use an atomizing spray gun to spray the above-mentioned solution onto a blank pellet core with a diameter of 100-200 μm, and dry it to prepare methylcobalamin drug-containing pellets.

[0055] (3) Dissolve Eudragit and EC with an appropriate amount of solvent to dissolve the slow-release material, and at the same time, add triethyl citrate, talcum powder, magnesium stearate or colloidal silicon dioxide into an appropriate amount of solvent to form a suspension liquid, and then add this suspension to the above-mentioned slow-release material solution under stirring and mix evenly to make a slow-release coating solution;

[0056] (4) Use an atomizing spray gun to ...

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PUM

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Abstract

The invention relates to a novel mecobalamin sustained-release capsule and a preparation method thereof. The mecobalamin sustained-release capsule comprises mecobalamin, povidone, eudragit and other commonly used auxiliary materials. The preparation method comprises the following steps of: preparing a medicated enveloping solution, coating medicated sustained-release membranes, preparing a sustained-release enveloping solution outside the medicated layer, coating the sustained-release membranes outside the medicated layer, preparing sustained-release pellets and capsules and filling. The novel mecobalamin sustained-release capsule can maintain a long-lasting and stable blood concentration after oral administration.

Description

technical field [0001] The invention relates to a novel methylcobalamin oral sustained-release capsule and a preparation method thereof, which are used for treating peripheral neuropathy or vitamin B deficiency 12 The megaloblastic anemia and other diseases caused by the invention belong to the field of pharmaceutical preparations. Background technique [0002] Methylcobalamin (Mecobalamin) is an endogenous coenzyme vitamin B developed by Eisai Co., Ltd. 12 Derivative preparations. Its chemical name is α-(5,6-dimethylbenzimidazolyl)-Co-methylcobamide, its English chemical name is a-(5,6-dinethylbenzimidazolyl)-Co-methyl-cobamide, and its molecular formula is C 63 h 91 CoN 13 o 14 P, molecular weight 1344.38. [0003] Clinical studies have shown that methylcobalamin has a good effect on the treatment of peripheral neuropathy such as diabetic neuropathy, polyneuritis, and megaloblastic anemia, and can treat some of the following diseases: [0004] 1. Peripheral facial p...

Claims

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Application Information

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IPC IPC(8): A61K9/58A61K9/62A61K9/56A61K31/714A61K47/34A61K47/38A61P25/02A61P7/06A61P3/02
Inventor 禹巧玲
Owner 广州艾格生物科技有限公司
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