The invention discloses a long-acting, harmless, washing-free and nonflammable high-molecular ethanol disinfectant, and belongs to the technical field of disinfectants. The long-acting, harmless, washing-free and nonflammable high-molecular ethanol disinfectant comprises, by volume, 100 parts of 70-80% medical alcohol, 2 parts of 91-99% butanediol, 10 parts of 0.2-1.8% sodium polyacrylate hydrogel, 3 parts of 0.4-2% amino acid humectant aqueous solution, 10 parts of 2.5-9.5 polyhexamethylene biguanidine hydrochloride aqueous solution, or 10 parts of 2-8% aloe hydrogel. The long-acting, harmless, washing-free and nonflammable high-molecular ethanol disinfectant is a liquid disinfectant or a gel disinfectant; the preparation ratio can be determined based on requirements; the adding amount isbetter than that of pure 75% alcohol; bacteria and virus killing range is wider; and the long-acting harmless washing-free nonflammable high-molecular ethanol disinfectant is excellent in killing effect, is capable of killing bacteria with double agents, is capable of inhibiting bacteria for a long time, is harmless, is nonflammable, is safe, is free of washing, and is widely suitable for disinfection of environment, office, medical treatment, home, life, and complete skin.