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Compound norfloxacin sustained release tablet and preparation method

A technology of norfloxacin and sustained-release tablets, which is applied in the field of compound norfloxacin sustained-release tablets and its preparation, can solve the problems of rapid-release preparations, such as frequent medication, diarrhea, nausea or vomiting, and poor patient compliance, to achieve enhanced Immunity of the body, improvement of compliance, and maintenance of drug efficacy

Inactive Publication Date: 2015-11-04
QINGDAO HAIZHIYUAN INTELLIGENT TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, oral administration of norfloxacin can easily lead to abdominal discomfort or pain, diarrhea, nausea or vomiting, and may also cause dizziness, headache, drowsiness or insomnia, and the frequent use of immediate-release preparations leads to poor patient compliance

Method used

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  • Compound norfloxacin sustained release tablet and preparation method
  • Compound norfloxacin sustained release tablet and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A compound norfloxacin sustained-release tablet. The components and parts by weight of the sustained-release tablet include 4 parts of norfloxacin, 33 parts of frankincense, 38 parts of Guya, 35 parts of divine music, 27 parts of dried ginger, Lu Ying 12 parts, 18 parts of Atractylodes macrocephala, 13 parts of Morinda officinalis, 35 parts of red dates, 6 parts of Magnolia officinalis leaves, 19 parts of Citrus aurantii, 13 parts of sodium alginate, 8 parts of starch, 0.7 parts of polysorbate, and 0.8 parts of micronized silica gel.

[0027] A preparation method of compound norfloxacin sustained-release tablet, comprising the following steps:

[0028] 1) preparing materials, preparing materials according to the components and parts by weight of a kind of compound norfloxacin sustained-release tablet, wherein the pharmaceutical auxiliary materials are pulverized through 80 mesh sieves, and norfloxacin is pulverized through 120 mesh sieves;

[0029]2) Extraction of the e...

Embodiment 2

[0036] A compound norfloxacin sustained-release tablet, the components and parts by weight of the sustained-release tablet include 3 parts of norfloxacin, 30 parts of frankincense, 35 parts of Guya, 30 parts of divine music, 25 parts of dried ginger, Lu Ying 10 parts, 15 parts of Atractylodes macrocephala, 10 parts of Morinda officinalis, 30 parts of red dates, 5 parts of Magnolia officinalis leaves, 15 parts of Citrus aurantii, 10 parts of sodium alginate, 5 parts of starch, 0.5 parts of polysorbate, and 0.5 parts of micronized silica gel.

[0037] A preparation method of compound norfloxacin sustained-release tablet, comprising the following steps:

[0038] 1) preparing materials, preparing materials according to the components and parts by weight of a kind of compound norfloxacin sustained-release tablet, wherein the pharmaceutical auxiliary materials are pulverized through 80 mesh sieves, and norfloxacin is pulverized through 120 mesh sieves;

[0039] 2) Extraction of the ...

Embodiment 3

[0046] A compound norfloxacin sustained-release tablet. The components and parts by weight of the sustained-release tablet include 5 parts of norfloxacin, 35 parts of frankincense, 40 parts of Guya, 40 parts of divine music, 30 parts of dried ginger, Lu Ying 15 parts, 20 parts of Atractylodes macrocephala, 15 parts of Morinda officinalis, 40 parts of red dates, 10 parts of Magnolia officinalis leaves, 20 parts of Citrus aurantii, 15 parts of sodium alginate, 10 parts of starch, 1 part of polysorbate, and 1 part of micronized silica gel.

[0047] A preparation method of compound norfloxacin sustained-release tablet, comprising the following steps:

[0048] 1) preparing materials, preparing materials according to the components and parts by weight of a kind of compound norfloxacin sustained-release tablet, wherein the pharmaceutical auxiliary materials are pulverized through 80 mesh sieves, and norfloxacin is pulverized through 120 mesh sieves;

[0049] 2) Extraction of the effe...

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Abstract

The invention discloses a compound norfloxacin sustained release tablet and a preparation method. The sustained release tablet comprises the following components: norfloxacin, frankincense, fructus setariae germinatus, medicated leaven, dried ginger, Luying, largehead atractylodes rhizome, morinda root, red dates, leaves of officinal magnolia bark, bitter orange, sodium alginate, starch, polysorbate and aerosil. The preparation method comprises the steps of material preparation, extraction of active ingredients of traditional Chinese medicines, granulation, drying, granule integration and tabletting. The sustained release tablet has the beneficial effects that the medicines have obvious synergistic effects, not only have the effect of improving the bacteriostatic and antiphlogistic effects of norfloxacin but also have the effect of overcoming the side effects of norfloxacin on gastrointestinal tracts and have the effects of tonifying the spleen and nourishing the stomach, thus improving the compliance of patients; the efficacy is maintained, the frequency of release to peak of the medicines is reduced and the visceral organs of the patients are also protected to a certain extent by controlling the concentrations of the medicines in blood.

Description

technical field [0001] The invention belongs to the field of quinolone antibacterial drugs, in particular to a compound norfloxacin sustained-release tablet and a preparation method thereof. Background technique [0002] Norfloxacin is a third-generation quinolone antibacterial drug, its chemical name is 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolone Phyloline carboxylic acid can hinder the action of DNA gyrase (DNAGyrase) of pathogenic bacteria, hinder bacterial DNA replication, and have an inhibitory effect on bacteria. It has broad-spectrum antibacterial effect, especially high antibacterial activity against aerobic Gram-negative bacilli, and is suitable for urinary tract infection, gonorrhea, prostatitis, intestinal infection, typhoid fever and other Salmonella infections caused by sensitive bacteria. [0003] Oral absorption of norfloxacin on an empty stomach is rapid but incomplete, about 30% to 40% of the dose; it is widely distributed in various ti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9068A61K9/22A61P31/04A61P29/00A61P1/14A61P1/00A61K31/496
Inventor 袁国防赵秀霞李明孙梅梅
Owner QINGDAO HAIZHIYUAN INTELLIGENT TECH
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