30 results about "Zinc hyaluronate" patented technology

The invention provides a method for preparing ultra-small molecular zinc hyaluronate, and relates to the field of hyaluronate. The method comprises the following steps: carrying out enzymolysis on macromolecular sodium hyaluronate by using leech hyaluronidase to obtain ultra-small molecular sodium hyaluronate; the method comprises the following steps: adsorbing ultra-small molecular sodium hyaluronate by using anion exchange resin, eluting by using a zinc salt solution, and reacting the obtained eluent to obtain ultra-small molecular zinc hyaluronate; the average molecular weight of the ultra-small molecular sodium hyaluronate is 600 Da to 1000 Da. The whole process is simple, the obtained ultra-small molecular zinc hyaluronate is high in zinc content, free of sodium ion residues and high in preparation yield, an organic solvent is not needed in the whole production process, and the method is suitable for industrial production.

The invention provides a high-water-absorption sodium alginate hydrogel dressing which is composed of a solution A and a solution B. The solution A is a sodium alginate solution, and the solution B is a calcium ion solution which comprises poloxamer, zinc hyaluronate and carbomer 941. The mass concentration range of the sodium alginate solution is 1%-7%, and the concentration range of the calcium ion solution is 100-400 mM; the volume ratio of the solution A to the solution B is (1: 2)-(3: 1). The smooth and transparent moist dressing can be rapidly obtained, the dressing can be customized according to the shape and size of a wound, the moisture retention rate is 86% or above, the swelling rate is 4000% or above, wound seepage can be absorbed, the moist environment of the wound is kept, and therefore wound healing is promoted.

The invention belongs to the technical field of medical preparations for pets, and particularly relates to an aloe extract-probiotic composite hydrogel for pet dermatosis, a preparation method comprises the following steps: under an aseptic condition, animal combined lactobacillus ZYpet-012 with the preservation number of CGMCC No.32008 is subjected to solid slant culture medium recovery and liquid culture, and then the animal combined lactobacillus ZYpet-012 with the preservation number of CGMCC No.32008 is subjected to freeze-drying to obtain the aloe extract-probiotic composite hydrogel for pet dermatosis. Centrifugally washing to obtain a probiotic suspension; the preparation method comprises the following steps: preparing blank hydrogel from carbomer 940, triethanolamine, zinc hyaluronate and the like; and mixing the aloe extract solution with the blank hydrogel, and then adding the probiotic suspension to prepare the composite hydrogel. According to the present invention, by using the anti-inflammatory, antibacterial and prebiotic characteristics of the aloe extract and combining the skin micro-ecology adjusting effect of the animal and the lactobacillus ZYpet-012, the prepared composite hydrogel can effectively treat the skin diseases of pets, and has advantages of nature, safety, accurate targeting and the like.

The invention relates to a zinc ion battery electrolyte containing polysaccharide zinc chelate as well as a preparation method and application thereof, the electrolyte comprises a deionized water solvent, a soluble zinc salt solute and a polysaccharide zinc chelate additive, and the addition amount of the polysaccharide zinc chelate additive is 0.20 mmol / L to 1.35 mmol / L; the polysaccharide zinc chelate additive is any one or more of zinc hyaluronate, zinc tannate, algal polysaccharide zinc, rice bran polysaccharide zinc chelate and multiflower knotweed vine polysaccharide chelated zinc. A trace amount of green and safe polysaccharide zinc chelate additive is added into the zinc salt water electrolyte, so that on one hand, hydrogen evolution side reaction is effectively inhibited, and on the other hand, dendritic crystal growth on the surface of a negative electrode is inhibited; when the electrolyte is applied to the aqueous zinc ion battery, the cycle stability of the battery can be remarkably improved, and the cycle life of the zinc ion battery is effectively prolonged.

The present application relates to a kind of zinc ion battery electrolyte containing polysaccharide zinc chelate and preparation method and application, the electrolyte includes deionized water solvent, soluble zinc salt solute and polysaccharide zinc chelate additive, the addition amount of the polysaccharide zinc chelate additive is 0.20 mmol / L~1.35 mmol / L;The polysaccharide zinc chelate additive is any one or multiple of zinc hyaluronate, zinc tannate, zinc alginic polysaccharide, rice bran polysaccharide zinc chelate, zinc chelate of radix mori polysaccharide.In the zinc salt aqueous electrolyte, a trace of green and safe polysaccharide zinc chelate additive is added, on the one hand, hydrogen evolution side reaction is effectively inhibited, on the other hand, the growth of negative electrode surface dendrite is inhibited;The electrolyte is applied to aqueous zinc ion battery, can significantly improve the cycle stability of battery, effectively prolong the cycle life of zinc ion battery.

The invention provides a multi-effect balanced private care hydrogel film as well as a preparation method and application thereof, and belongs to the technical field of medical biological materials. By integrating traditional Chinese medicine antibacterial components, inactivated probiotics and a hydrogel slow release technology, the hydrogel film with a three-layer structure, which has the functions of inhibiting bacteria, repairing mucous membranes and maintaining pH balance, is developed, and matrine inhibits staphylococcus aureus (the diameter of an inhibition zone is greater than or equal to 15mm); inactivated bacteria competitively inhibit the adhesion of pathogenic bacteria (the in-vitro adhesion inhibition rate is greater than or equal to 70%); zinc hyaluronate promotes mucous membrane repair (the cell migration rate is increased by 40%), and through the multi-target-point synergistic effect, good nursing and postoperative repair effects are achieved.

The present invention provides a natural skin care hydrogel for pet wounds and a preparation method and application thereof, wherein the raw materials for preparing the hydrogel include: a gel forming agent, a moisturizing agent, aloe polysaccharide, zinc hyaluronate, saccharic acid, laurocapron, zinc gluconate, vitamin E, vitamin B, PEG-40 castor oil, polyethylene glycol, triethanolamine, mint essence, ethyl hydroxybenzoate and deionized water. The natural hydrogel matrix screened out by the present invention can absorb and retain a large amount of water to form a soft, elastic and transparent gel-like substance; the gel has a uniform appearance and has the dual effects of hydration and absorption, and has good gel network mechanical properties, density, apparent viscosity, water absorption and moisturizing air permeability, can keep the wound surface moist and have the dual effects of hydration and absorption, autonomously moisturize the wound surface to promote epidermal growth and epithelial regeneration, prolong the contact time with the skin, and improve the absorption of effective substances; the physicochemical properties are stable, and it is a very ideal skin dressing for external use.

The invention discloses an oil-control and anti-dandruff composition and application thereof, and relates to the technical field of daily chemical products. The oil-controlling and anti-dandruff composition comprises polyol, an active component A and an active component B, the active ingredient A is selected from bioflavonoid and / or plankton extract; and the active ingredient B is selected from at least one of zinc gluconate, zinc lactate, zinc PCA, zinc cocoyl alcohol polyether sulfate and zinc hyaluronate. According to the oil-control and anti-dandruff composition, the active ingredient A can effectively reduce sebum secretion and regulate the sebum level; and the active component B has good antibacterial performance, can remove biological membranes, obviously improve oily scalp and enhance scalp barrier. All the components are compounded and can achieve mutual synergistic interaction, bacteriostasis and biofilm disintegration are achieved from the source, long-acting dandruff removal and oil control are achieved, meanwhile, the scalp barrier function is improved, and scalp discomfort is relieved.

The invention provides a composition for inhibiting activity of 5 alpha-reductase and application of the composition, the composition comprises zinc hyaluronate and vitamin B6, the mass ratio of the zinc hyaluronate to the vitamin B6 is (0.1-3.5): (0.005-1.3), the zinc hyaluronate and the vitamin B6 in the composition have a synergistic effect, the activity of the 5 alpha-reductase can be safely and effectively inhibited, and the activity of the 5 alpha-reductase is inhibited. When the composition is used for preparing a scalp care composite solution, the water content of scalp cuticle can be increased, scalp dryness can be relieved, excessive secretion of scalp sebum can be inhibited, and proliferation of hair papilla cells can be improved.

The invention provides multi-effect composite scar repair gel as well as a preparation method and application thereof, and belongs to the technical field of biological medicines. The invention develops a multi-effect composite scar repair gel with barrier protection, anti-inflammatory regeneration and long-acting permeation by integrating a silicone base material, traditional Chinese medicine active ingredients and an ionic liquid permeation promotion technology. Wherein the high-viscosity polydimethylsiloxane is used for reducing skin tension; the low-viscosity polydimethylsiloxane improves the skin comfort level; the traditional Chinese medicine extract inhibits fibroblast proliferation and promotes microcirculation; the Ectoin-allantoin microcapsule is capable of realizing 72-hour slow-release anti-inflammatory repair; the BPC157 polypeptide can promote angiogenesis and accelerate wound healing; the transdermal rate of the active ingredients is increased by more than 3 times by the arginine-malic acid ionic liquid; the zinc hyaluronate can synergistically moisturize and regulate the inflammation microenvironment. Through cooperation of multiple mechanisms, the effects of barrier protection, anti-inflammatory regeneration and long-acting permeation are achieved, and the anti-inflammatory and long-acting anti-inflammatory ointment is suitable for repairing hypertrophic scars, acne scars and postoperative incisions.

The application relates to the field of inorganic particle preparation, and particularly discloses modified inorganic particles and a preparation process thereof. The preparation raw materials comprise the following components by weight: component 1: at least one of spherical porous silica, bentonite and diatomite, 100 parts; component 2: at least one of hydrolyzed hyaluronic acid, sodium hyaluronate and zinc hyaluronate, 0.2-5 parts; and component 3: at least one of triethoxyl octyl silane, polydimethylsiloxane, polymethylsiloxane, polydimethylsiloxane alcohol, phenyl silicone oil, lauroyl lysine and hydrogenated lecithin, 0.5-10 parts. The preparation process comprises the following steps: component 2 and a film coating aid are added into deionized water to prepare a solution, and the solution is preserved at 10-15 DEG C; component 1 is placed in a boiling coating machine and suspended in hot air for boiling; the solution is sprayed on component 1, and the temperature is raised to 100-110 DEG C for treatment for 6-8 h to obtain a powder; the powder is added into a high-speed mixer, component 3 is further added and mixed for 20-30 min, and then drying and crushing are carried out to obtain the modified inorganic particles. The hydrolyzed hyaluronic acid and derivatives and the film coating aid are prepared into a solution and sprayed on the suspended and boiled particles to realize coating of the porous particles, compared with a conventional mixing process, the porous particles can be effectively coated, and the effect of reducing oil absorption is realized.

The invention discloses a self-healing pH-sensitive hydrogel and a preparation method and application thereof, the self-healing pH-sensitive hydrogel comprises a carrier and a bioactive compound loaded on the carrier, the carrier is a cationic guar gum / hyaluronic acid / zinc ion compound, and the bioactive compound is a ferulic acid / beta-cyclodextrin compound; the synergistic antibacterial effect is achieved through FA, Zn and CG, meanwhile, FA and CG provide oxidation resistance, the hydrogel is endowed with self-repairing performance through electrostatic interaction of carboxyl in HA and quaternary ammonium salt groups in CG, and the wound healing effect of the hydrogel is comprehensively improved.

The present invention provides an antibacterial composition and a preparation method and application thereof, wherein the antibacterial composition comprises peony extract, licorice extract and hydrolyzed zinc hyaluronate. The antibacterial composition of the present invention is added with a variety of natural Chinese medicine ingredients, and through scientific formula and proportion, the synergistic effect between the ingredients, especially the peony extract, licorice extract and hydrolyzed zinc hyaluronate, greatly improves the antibacterial, anti-inflammatory, repair and protective effects, and is particularly suitable for combating skin diseases caused by Staphylococcus pseudointermedius, which can not only inhibit the growth of bacteria, but also help alleviate skin inflammation caused by excessive bacterial growth.

The invention discloses a compound oral gargle composition and a preparation method thereof, and relates to the technical field of oral gargle. The compound oral gargle composition comprises the following components: a compound active component, a mucous membrane repairing agent, an anti-inflammatory synergist, a humectant, a solubilizer, a flavoring agent, a pH regulator and water, the content sum of the components is 100 wt%, the compound active component is povidone iodine and tinidazole, and the mucous membrane repairing agent is at least one of chitosan, zinc hyaluronate and silk fibroin. Through the synergistic effect of the composite active ingredients and the mucous membrane repairing agent, the curative effect is improved, the oral environment can be effectively improved, and the effects of diminishing inflammation, repairing mucous membranes and the like are achieved.

The application discloses a human soft tissue filling material and a preparation method thereof, wherein the human soft tissue filling material comprises the following components in parts by weight: 45-75 parts of cross-linked zinc hyaluronate gel, 30-50 parts of bioglass, 5-15 parts of hydroxyapatite, 0.5-5 parts of glycerol, 0.1-0.25 parts of lidocaine hydrochloride and 0.1-0.7 parts of dexamethasone. The preparation method of the human soft tissue filling material is simple in process, convenient in operation and low in cost, and the prepared human soft tissue filling material is slow in degradation speed, good in antibacterial property and biocompatibility and difficult to be displaced.

The invention belongs to the technical field of chemicals, and particularly relates to a zinc hyaluronate-containing wound repair spray as well as a preparation method and application thereof. The wound repair spray containing zinc hyaluronate is prepared from the following components in percentage by mass: 0.05 to 5 percent of low molecular weight zinc hyaluronate, 0.05 to 5 percent of high molecular weight zinc hyaluronate, 0.01 to 1 percent of synergistic component, 2.0 to 8.0 percent of glycerol, 1.0 to 5.0 percent of propylene glycol, 0.05 to 0.5 percent of alpha-glucan oligosaccharide, 0.1 to 1.0 percent of serine, 0.05 to 0.3 percent of water-soluble polymer and the balance of water. The prepared wound repairing spray containing the zinc hyaluronate can be combined with a vacuum sealing drainage technology for use, and can promote rapid healing of pressure injury.

The present invention provides a method for preparing zinc hyaluronate, comprising the following steps: adding sodium hyaluronate into an acidic aqueous organic medium containing a zinc salt for a first replacement to obtain a zinc hyaluronate precipitate; washing the precipitate with a washing solution; dehydrating the washed precipitate with a dehydrating solution and drying to obtain zinc hyaluronate powder. Based on the solid replacement method, the present invention optimizes the zinc salt concentration, the volume of the replacement solution, the replacement time, and the number of replacement times in the replacement solution, solves the problems of multiple replacement times, long time consumption, large molecular weight consumption, and low zinc salt utilization rate in the current zinc hyaluronate production process, greatly shortens the production cycle, improves the replacement efficiency, reduces the contact time between the raw materials and the acidic replacement solution, and avoids a significant reduction in the molecular weight of the product. The present invention provides a method for rapidly and efficiently producing zinc hyaluronate, which is applicable to the large-scale production of zinc hyaluronate.

The invention provides a preparation method of zinc hyaluronate, which comprises the following steps: adding sodium hyaluronate into an acidic water-containing organic medium containing zinc salt, and carrying out primary replacement to obtain a zinc hyaluronate precipitate; washing the precipitate with a washing liquid; and dehydrating the washed precipitate with a dehydration liquid, and drying to obtain the zinc hyaluronate powder. On the basis of a solid replacement method, the concentration of zinc salt in the replacement liquid, the volume of the replacement liquid, the replacement time and the number of replacement times are optimized, the problems that in an existing zinc hyaluronate production process, the number of replacement times is large, consumed time is long, molecular weight consumption is large, and the utilization rate of zinc salt is low are solved, the production period is greatly shortened, and the replacement efficiency is improved; the contact time of the raw material and the acid displacement liquid is reduced, and the great reduction of the molecular weight of the product is avoided. The invention provides a method for rapidly and efficiently producing zinc hyaluronate, which is suitable for large-scale production of zinc hyaluronate.

This invention discloses a composition containing myxobin and zinc hyaluronic acid and its application. The present invention combines myxobin and zinc hyaluronic acid in a specific ratio, which, when used alone, has a better effect on reducing DHT damage to hair follicles and also better promotes hair follicle angiogenesis, exhibiting a synergistic effect on hair growth and hair loss prevention.

The invention belongs to the field of pharmacy, and particularly discloses a salbutamol instant tablet based on a freeze drying-microsphere embedding technology and a preparation process. The tablet comprises a porous matrix formed by freeze drying and salbutamol-loaded microspheres dispersed in the porous matrix, the microspheres are formed by ionic crosslinking of zinc hyaluronate and pullulan polysaccharide (the mass ratio is 1: 0.5-1: 3), the diameter is 20-150 microns, and the zinc ion content is 0.5-5%. And the porous matrix contains a sorbitol-povidone K30 freeze-drying protective agent (3: 1-6: 1, 8-12%). The preparation process comprises the following steps: dissolving salbutamol and zinc hyaluronate in an acetic acid buffer solution, dropwise adding a pullulan solution containing calcium ions to form microspheres, quickly freezing with liquid nitrogen, and carrying out gradient freeze drying (-35 DEG C to-15 DEG C to 10 DEG C to 25 DEG C). The tablet disintegration time is less than or equal to 8 seconds, the dissolution rate in 5 minutes is greater than or equal to 90%, the increase of related substances accelerated for 6 months is less than or equal to 0.5%, the bitterness score is less than or equal to 1.5 score, and the tablet is suitable for first aid of children asthma and exercise asthma.

This invention discloses an antibacterial composition containing lysozyme and zinc hyaluronic acid and its application, wherein the mass ratio of the active ingredients lysozyme and zinc hyaluronic acid is 0.5-30:1. This invention combines zinc hyaluronic acid and lysozyme to achieve a synergistic antibacterial effect, simultaneously killing bacteria, Candida albicans, and Aspergillus niger, with a particularly significant effect on Aspergillus niger. It also possesses excellent preservative properties and can be used as a preservative in cosmetics and pharmaceuticals, serving as a good natural preservative that can replace chemical preservatives. Furthermore, zinc hyaluronic acid has moisturizing properties, providing both safe preservation and skin stabilization, promoting skin health. When used as a cosmetic preservative, it can replace chemical preservatives, while also offering moisturizing and anti-inflammatory effects with improved safety.

The invention provides a preparation method of monodisperse cross-linked hyaluronic acid microspheres. The preparation method comprises the following steps: (1) preparing an internal phase fluid which contains hyaluronic acid or zinc hyaluronate and a cross-linking agent and has a pH value of 4-6, preparing an external phase fluid containing an oil-soluble surfactant, and preparing a collecting solution containing the oil-soluble surfactant and an activating agent; and (2) preparing a monodisperse water-in-oil emulsion through a microfluidic technology, collecting the water-in-oil emulsion by adopting a container containing a collecting solution, activating carboxyl of hyaluronic acid or zinc hyaluronate in the water-in-oil emulsion by using an activating agent in the collecting solution, and further carrying out a cross-linking reaction with a cross-linking agent to convert the water-in-oil emulsion into microspheres, and washing and drying the obtained microspheres. The particle size variation coefficient of the cross-linked hyaluronic acid microspheres prepared by the method does not exceed 6%, and the cross-linked hyaluronic acid microspheres prepared by the method have good monodispersity.

The present invention belongs to the technical field of pharmaceutical preparations for pets, and particularly relates to an aloe vera extract-probiotic composite hydrogel for treating pet skin diseases. The preparation method comprises: under sterile conditions, resuscitating Lactobacillus zonitrosum ZYpet-012 (CGMCC No. 32008) in a solid slant culture medium, culturing in a liquid culture medium, and then centrifuging and washing to obtain a probiotic suspension; preparing a blank hydrogel using carbomer 940, triethanolamine, and zinc hyaluronate; mixing the aloe vera extract solution with the blank hydrogel, and then adding the probiotic suspension to produce the composite hydrogel. This invention utilizes the anti-inflammatory, antibacterial, and prebiotic properties of aloe vera extract, combined with the skin microbiome-regulating effects of Lactobacillus zonitrosum ZYpet-012, to prepare a composite hydrogel that is effective in treating pet skin diseases, offering advantages such as natural safety and precise targeting.

The invention belongs to the technical field of functional dressings, and discloses a liquid dressing for skin repair as well as a preparation method and application thereof, the liquid dressing for skin repair is prepared from the following raw materials in percentage by weight: 1-5% of zinc hyaluronate, 2-10% of giant salamander collagen, 1-8% of aloe polysaccharide, 0.5-6% of L-lactic acid, 0.5-2% of carbomer, 0.1-0.5% of preservative, 0.1-2% of pH regulator and the balance of purified water. The components of the dressing are reasonably proportioned and synergistically gained, and the dressing has the effects of resisting bacteria, resisting oxidation, promoting angiogenesis and the like, can effectively promote skin wound repair, and also has good safety and use comfort.

The invention discloses a preparation method and application of zinc hyaluronate, and belongs to the technical field of biomedicine. The preparation method comprises the following steps: mixing sodium hyaluronate and deionized water, stirring to obtain a sodium hyaluronate solution; dissolving zinc chloride in deionized water, stirring to obtain a zinc chloride aqueous solution; mixing the zinc chloride aqueous solution with the sodium hyaluronate solution, stirring, adding a hydrochloric acid solution to adjust the pH to 5-5.5, then heating to 40-45°C, stirring, then adding an accelerator, and adding a hydrochloric acid solution to continue adjusting the pH to 4-4.5, continuing stirring, filtering, and then adding anhydrous ethanol to the filtrate for precipitation, until no agglomeration is generated, washing the precipitate with anhydrous ethanol, dehydrating, granulating, and vacuum drying. The method has a mild reaction process, simple separation and purification steps, low production cost, is suitable for industrial production, and the prepared zinc hyaluronate has high zinc content, low sodium content, can be quickly dissolved in a solution, and has high light transmittance.

The invention provides a preparation method of a sodium alginate hydrogel mask with high water content, which comprises the following steps: smearing a solution A into a specific shape, then smearing a solution B onto the surface of the solution A with the specific shape, and carrying out cross-linking reaction on the solution A and the solution B to obtain the sodium alginate hydrogel mask with a self-defined shape, the solution A is a sodium alginate solution with the mass concentration range of 1%-7%; the solution B is a calcium ion solution with the concentration range of 100-400 mM, and comprises poloxamer, zinc hyaluronate and carbomer 941. The smooth and transparent wet mask can be rapidly obtained, the use shape and size of the mask are customized, and different whitening, anti-inflammatory and other components can be added according to the skin state. Besides, the mask has the moisturizing rate of 88% or above and the swelling rate of 4100% or above, and the skin moisture can be increased by 32% after the mask is used for 15 minutes, so that the skin water-oil state is improved, and a better using effect is achieved.

The present application provides a preparation method for zinc hyaluronate, comprising the following steps: adding sodium hyaluronate into an acidic water-comprising organic medium that contains a zinc salt, and carrying out primary replacement to obtain a zinc hyaluronate precipitate; washing the precipitate using a washing liquid; dehydrating the washed precipitate using a dehydration liquid and drying same to obtain a zinc hyaluronate powder. The present application optimizes, on the basis of a solid replacement method, the zinc salt concentration in the replacement liquid, the replacement liquid volume, the replacement time, and the number of replacements, and solves the problems of numerous replacements, long time, large molecular weight consumption, and low zinc salt utilization rate in existing zinc hyaluronate production processes. The production cycle is greatly shortened, the replacement efficiency is improved, the contact time between the raw materials and the acidic replacement liquid is reduced, and the molecular weight of the product is prevented from being greatly lowered. The present application provides a method for rapidly and efficiently producing zinc hyaluronate, which is suitable for large-scale production of zinc hyaluronate.

The invention discloses a preparation method of grapefruit hand cream, and belongs to the technical field of cosmetics. The method comprises the following steps: S1, mixing and stirring a first clathrate, a compound, a second clathrate, samara oil, beewax, polyglycerol-6 distearate and a composite microcapsule, the first clathrate is prepared by coating pomelo peel polyphenol with hydroxypropyl-beta-cyclodextrin and the like, and the compound comprises pomelo hydrolat and polyglycerol-10 laurate; the second inclusion compound is prepared by coating a ginger root-Chinese prickly ash extract with methyl-beta-cyclodextrin and the like; the composite microcapsule contains limonene, a grapefruit seed extract and the like; s2, dissolving hydrolyzed tremella polysaccharide and other components in deionized water, adding zinc hyaluronate and the composite system after enzymolysis, and shearing and emulsifying with the oil phase in S1; s3, cooling the emulsifying system, adding the grapefruit flower extract and vitamin E, uniformly stirring, refrigerating and shaping, and recovering to room temperature to obtain a finished product. The hand cream prepared by the invention can help to improve the problems that the hand cream is poor in component compounding compatibility, easy to degrade in efficacy, hard in paste at low temperature and the like.

The invention relates to the field of inorganic particle preparation, and particularly discloses a modified inorganic particle and a preparation process thereof. The preparation raw materials comprise the following components in parts by weight: a component 1: 100 parts of at least one of spherical porous silica, bentonite and diatomite; a component 2: 0.2-5 parts of at least one of hydrolyzed hyaluronic acid, sodium hyaluronate and zinc hyaluronate; a component 3: 0.5 to 10 parts of at least one of triethoxyoctyl silane, polydimethylsiloxane, polymethylsiloxane, polydimethylsiloxane alcohol, phenyl silicone oil, lauroyl lysine and hydrogenated lecithin; the preparation process comprises the following steps: adding the component 2 and the coating aid into deionized water to prepare a solution, and preserving heat at 10-15 DEG C; placing the component 1 in a boiling coating machine, and suspending and boiling in hot air; spraying the solution on the component 1, heating to 100-110 DEG C, treating for 6-8 hours to obtain powder, adding the powder into a high-speed mixer, adding the component 3, mixing for 20-30 minutes, drying, and crushing to obtain the modified inorganic particles. According to the present invention, the solution prepared from the hydrolyzed hyaluronic acid and the derivative thereof and the coating auxiliary agent is sprayed on the suspended boiling particles so as to coat the porous particles, such that the effective coating of the porous particles can be achieved compared with the conventional mixing process so as to achieve the oil absorption retarding effect;

The invention provides a trypsin inhibitor and application thereof, and relates to the technical field of molecular biology. According to the invention, it is found for the first time that zinc pyrithione, ketoconazole and / or selenium disulfide have an inhibition effect on trypsin activity, and new functional components which are convenient to obtain are provided for the trypsin inhibitor. The invention provides three compositions containing zinc hyaluronate, the zinc hyaluronate is respectively compounded with zinc pyrithione, ketoconazole or selenium disulfide according to a specific mass ratio, and it is found for the first time that the zinc hyaluronate and the zinc pyrithione, ketoconazole or selenium disulfide show the activity of synergistically inhibiting trypsin. The composition provided by the invention is simple to obtain, can be continuously compounded with other functional active components or auxiliary material components to obtain commercial products, and has a wide application prospect.