The invention discloses eye irritation-free cleansing bubble with functions of makeup removal and skin care, and a preparation method of the cleansing bubble. The cleansing bubble is mainly prepared from the following components: water, glycerin, sodium lauroyl oat amino acids, potassium cocoyl glycinate, ammonium lauryl sulfate, cocamide MEA, an acrylate/vinyl neodecanoate cross-linked polymer, cocamidopropyl betaine, sodium PEG-7 olive oil carboxylate, a hamamelis virginiana extract, an iris florentina root extract, a rosemary extract, a licorice root extract, dipotassium glycyrrhizinate, sodium hyaluronate, 1, 2-hexanediol, beta-glucan, disodium ethylene diamine tetraacetic acid (EDTA), fullerene, leuconostoc/radish root fermention product filtrate and neroli oil. The preparation methodcomprises the following preparation processes: weighing the raw material according to a proportion, heating for dissolving, mixing and stirring, cooling, detecting, filling, testing, and the like. The prepared cleansing bubble solves the problems that a great deal of active agent is added into the traditional cleanser, thus causing the skin to lose vitality, and after being used, oily makeup remover can not be cleaned at a time, thus easily enabling the skin pores to become larger and easily causing skin allergy.