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Compound norfloxacin composition and preparation method

A technology of norfloxacin and composition, applied in the field of compound norfloxacin composition and preparation, can solve the problems of poor patient compliance, abdominal discomfort, etc., achieve the effects of promoting absorption, improving antibacterial and anti-inflammatory, and simple formula

Inactive Publication Date: 2015-11-04
QINGDAO HAIZHIYUAN INTELLIGENT TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, oral administration of norfloxacin can easily lead to abdominal discomfort or pain, diarrhea, nausea or vomiting, and may also cause dizziness, headache, drowsiness or insomnia, and ultimately lead to poor patient compliance

Method used

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  • Compound norfloxacin composition and preparation method
  • Compound norfloxacin composition and preparation method

Examples

Experimental program
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Effect test

Embodiment 1

[0025] A compound norfloxacin composition, the components and parts by weight of the composition include 4 parts of norfloxacin, 33 parts of frankincense, 38 parts of Guya, 35 parts of divine music, 27 parts of dried ginger, and 12 parts of luying , 18 parts of Atractylodes macrocephala, 13 parts of Morinda officinalis, 35 parts of red dates, 6 parts of Magnolia officinalis leaves, 19 parts of Citrus aurantii, 7 parts of sodium carboxymethyl starch, 8 parts of low-substituted hydroxypropyl cellulose, 12 parts of starch, sucrose ester 0.7 parts, micronized silica gel 0.8 parts.

[0026] A preparation method of compound norfloxacin composition, comprises the following steps:

[0027] 1) preparing materials, preparing materials according to the components and parts by weight of a kind of compound norfloxacin composition, wherein the pharmaceutical adjuvant is pulverized through 80 mesh sieves, and norfloxacin is pulverized through 120 mesh sieves;

[0028] 2) Extraction of the e...

Embodiment 2

[0035] A compound norfloxacin composition, the components and parts by weight of the composition include 3 parts of norfloxacin, 30 parts of frankincense, 35 parts of Guya, 30 parts of divine music, 25 parts of dried ginger, and 10 parts of luying , 15 parts of Atractylodes macrocephala, 10 parts of Morinda officinalis, 30 parts of red dates, 5 parts of Magnolia officinalis leaves, 15 parts of Citrus aurantii, 5 parts of sodium carboxymethyl starch, 5 parts of low-substituted hydroxypropyl cellulose, 10 parts of starch, 0.5 parts of sucrose ester part, 0.5 part of micropowder silica gel.

[0036] A preparation method of compound norfloxacin composition, comprises the following steps:

[0037] 1) preparing materials, preparing materials according to the components and parts by weight of a kind of compound norfloxacin composition, wherein the pharmaceutical adjuvant is pulverized through 80 mesh sieves, and norfloxacin is pulverized through 120 mesh sieves;

[0038] 2) Extracti...

Embodiment 3

[0045] A compound norfloxacin composition, the components and parts by weight of the composition include 5 parts of norfloxacin, 35 parts of frankincense, 40 parts of Guya, 40 parts of divine music, 30 parts of dried ginger, and 15 parts of luying , 20 parts of Atractylodes macrocephala, 15 parts of Morinda officinalis, 40 parts of red dates, 10 parts of Magnolia officinalis leaves, 20 parts of Citrus aurantii, 10 parts of sodium carboxymethyl starch, 10 parts of low-substituted hydroxypropyl cellulose, 15 parts of starch, sucrose ester 1 part, 1 part of micropowder silica gel.

[0046] A preparation method of compound norfloxacin composition, comprises the following steps:

[0047] 1) preparing materials, preparing materials according to the components and parts by weight of a kind of compound norfloxacin composition, wherein the pharmaceutical adjuvant is pulverized through 80 mesh sieves, and norfloxacin is pulverized through 120 mesh sieves;

[0048] 2) Extraction of the ...

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Abstract

The invention discloses a compound norfloxacin composition and a preparation method. The composition comprises the following components: norfloxacin, frankincense, fructus setariae germinatus, medicated leaven, dried ginger, Luying, largehead atractylodes rhizome, morinda root, red dates, leaves of officinal magnolia bark, bitter orange, sodium carboxymethyl starch, low-substituted hydroxypropyl cellulose, starch, sucrose ester and aerosil. The preparation method comprises the steps of material preparation, extraction of active ingredients of active pharmaceutical ingredients of traditional Chinese medicines, granulation, drying, granule integration and tabletting / encapsulation. The composition has the beneficial effects that the medicines have obvious synergistic effects, not only have the effect of improving the bacteriostatic and antiphlogistic effects of norfloxacin but also have the effect of overcoming the side effects of norfloxacin on gastrointestinal tracts and have the effects of tonifying the spleen and nourishing the stomach, thus improving the compliance of patients; the composition is reasonable in usage amount of the medicinal auxiliary materials and usage amount selection and is simple in formula; the preparation process is reasonable and stable, has good reproducibility and easily achieves industrial production; the cost is low, thus being beneficial to reducing the product price.

Description

technical field [0001] The invention belongs to the field of quinolone antibacterial drugs, in particular to a compound norfloxacin composition and a preparation method. Background technique [0002] Norfloxacin is a third-generation quinolone antibacterial drug, its chemical name is 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolone Phenylcarboxylic acid can hinder the action of DNA gyrase (DNA Gyrase) of pathogenic bacteria, hinder bacterial DNA replication, and have an inhibitory effect on bacteria. It has broad-spectrum antibacterial effect, especially high antibacterial activity against aerobic Gram-negative bacilli, and is suitable for urinary tract infection, gonorrhea, prostatitis, intestinal infection, typhoid fever and other Salmonella infections caused by sensitive bacteria. [0003] Oral absorption of norfloxacin on an empty stomach is rapid but incomplete, about 30% to 40% of the dose; it is widely distributed in various tissues and body fluids, s...

Claims

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Application Information

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IPC IPC(8): A61K36/9068A61P31/04A61P29/00A61P1/14A61P1/00A61K31/496
Inventor 袁国防赵秀霞李明孙梅梅
Owner QINGDAO HAIZHIYUAN INTELLIGENT TECH
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