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Near-infrared fluorescent magnetic micro-emulsion nanometer particle, its preparation method and application

A technology of nanoparticles and magnetic particles, which is applied in the fields of nanoparticles and their preparation and application in tumor treatment, can solve the problems of tumors that do not have targeted therapy

Inactive Publication Date: 2005-11-23
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the thermal effect produced by the nanocomposite particles prepared by L.R.Hirsch et al. is formed by self-heating after absorbing light energy, and the heat needs to be transmitted through the tumor cells and their gaps to reach distant places. Moreover, this Nanocomposite particles do not have a good function of targeting tumor therapy
In addition, the main effect of killing tumors is the thermal effect, and there is no strong oxidizing and reducing substances produced under light excitation to kill tumors like semiconductor nanoparticles.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Under the protection of nitrogen, the brown transparent cadmium telluride (CdTe) nanoparticle solution is obtained by reacting in a certain molar ratio with sodium hydride telluride and a protective agent as raw materials in an aqueous solution of pH=10.0, further aging and After passivation treatment, the maximum emission wavelength of the obtained emission spectrum of CdTe is about 700nm, and the fluorescence tails to 840nm.

[0032] Under nitrogen protection, the FeCl 3 ·6H 2 O and FeCl 2 4H 2 O was co-dissolved in 50 mL of polyethylene glycol (PVA) aqueous solution with a concentration of 0.3w%, and sodium hydroxide solution was added dropwise to the mixed solution at 80° C. under magnetic stirring until the pH of the reaction solution reached 11. After the reaction liquid is cooled naturally, adopt magnetic separation and wash the black product, then disperse the product in 0.5w% PVA aqueous solution, and ultrasonically disperse to obtain black spherical ferric ...

Embodiment 2

[0035] With the CdTe and Fe that embodiment 1 obtains 3 o 4 raw materials for nanoparticles.

[0036] Dissolve an appropriate amount of egg yolk lecithin into 5mL of ethanol solution, then dissolve the solution into 15mL of isopropyl myristate, then add CdTe nanoparticle aqueous solution dropwise to the mixed solution, shake, and obtain a clear and transparent brown color CdTe microemulsion.

[0037] In addition, an appropriate amount of egg yolk lecithin was dissolved in 5 mL of ethanol solution, and then the solution was dissolved in 12 mL of isopropyl myristate, and then Fe was added dropwise to the mixed solution. 3 o 4 Aqueous solution, shaking, the result is a uniform Fe 3 o 4 Microemulsion.

[0038] Then the microemulsion of CdTe with Fe 3 o 4 The microemulsion is mixed in equal volume and oscillated to obtain simultaneous embedding of CdTe and Fe 3 o 4 microemulsion. Filter and sterilize through a 0.22 μm microporous membrane, and store in a nitrogen-sealed ...

Embodiment 3

[0040] Replace the CdTe in Example 1 with an appropriate concentration of near-infrared fluorescent silicon phthalocyanine derivatives (LaJolla Blue, the maximum emission wavelength is 680nm), and prepare simultaneously embedding LaJolla Blue and Fe by the same method as in Example 1. 3 o 4 microemulsion. As a result, a homogeneous emulsion is also obtained, which has strong magnetic properties.

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Abstract

The invention discloses a near-infrared fluorescent magnetic micro-emulsion nanometer particle, its preparation method and application in tumor treatment, wherein magnetic nano-particles and near-infrared luminescent quantum dot nano-particles or near-infrared luminescent organic dyestuff molecules are embedded into water-in-oil micro-emulsion, anti-cancer drugs can also be embedded into the micro-emulsion, the magnetic steering action of the magnetic nano particles will target the micro-emulsion embedded near-infrared fluorescent substances to tumor positions or secure them onto tumor positions under the excitation of near-infrared lights, the thermal effects produced by the near-infrared lights can kill tumor cells, the OH and O2 free radicals with high activity and the optical catalytic activity of the quantum dots can also have synergic actions in destroying tumor cells.

Description

technical field [0001] The present invention relates to a nanoparticle and its preparation and application in tumor treatment, especially to near-infrared fluorescent magnetic microemulsion nanoparticles and its preparation and application in tumor targeted therapy, belonging to nanotechnology and biomedicine cross field. Background of the invention [0002] Malignant tumors are frequently-occurring and common diseases that seriously threaten human health. According to the data released by the World Health Organization in 2003, there were 10 million malignant tumor patients in the world in 2000, including 5.3 million males and 4.7 million females; 6.2 million deaths due to malignant tumors, accounting for 12% of the total deaths, in most developed countries This figure can reach 25%. In developing countries, due to the acceleration of urbanization, the eating habits and the occurrence of tumors closely related to it will gradually change to the type of economically develop...

Claims

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Application Information

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IPC IPC(8): A61K9/107
CPCA61K47/48792A61K41/0057A61K41/0052A61K47/48861A61K47/6905A61K47/6923
Inventor 储茂泉
Owner TONGJI UNIV
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