A selectable area high dynamic laser speckle blood flow imaging device and method

A laser speckle, imaging device technology, applied in blood flow measurement, medical science, sensors, etc., can solve problems such as inability to meet exposure time requirements and differences

Active Publication Date: 2019-01-04
FOSHAN UNIVERSITY
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Problems solved by technology

However, in the whole-body blood flow imaging of biological samples, since different parts of the biological sample often have different thicknesses, and the blood flow information of different parts is different, so a single exposure time may not be able to meet the imaging requirements of different parts. Exposure Time Requirements

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  • A selectable area high dynamic laser speckle blood flow imaging device and method
  • A selectable area high dynamic laser speckle blood flow imaging device and method
  • A selectable area high dynamic laser speckle blood flow imaging device and method

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Embodiment Construction

[0031] In order to facilitate those of ordinary skill in the art to better understand the essence of the present invention, the specific implementation manners of the present invention will be described in detail below in conjunction with the accompanying drawings.

[0032] combine figure 1 , an optional high dynamic laser speckle blood flow imaging device, including a laser light source 1, a sample fixing table 2, a beam expander 3, a half mirror 4, a first CCD camera 5, a second CCD camera 6 and a stepper The motor 7 firstly fixes the entire device on the vibration-isolation optical platform, then fixes the sample to be tested on the sample stage 2, turns on the laser light source 1 to emit the laser beam, and realizes the enlargement of the irradiation area of ​​the laser through the beam expander, and also makes the laser The irradiation is more uniform, and then the enlarged laser beam is irradiated on the sample to be tested, and the scattering particles in the sample to...

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Abstract

A selectable high dynamic laser speckle blood flow imaging device and method include a laser source, a sample fixing table, a beam expander, a half-mirror, a first CCD camera, a second CCD camera anda stepping motor. Continuous acquisition of original speckle images using multi-exposure acquisition is carried out, which solves the shortcoming of the traditional laser speckle contrast imaging method that the original speckle image is captured by a fixed exposure time. In addition, the present invention provides a dual imaging system. The whole body blood flow image is obtained by the focusingsystem, the local area is enlarged by the zoom system to obtain the angiographic image with more blood vessel information, and the images obtained by the two optical systems are fused to obtain the angiographic image with higher imaging resolution. It will be of great significance in the fields of early diagnosis of diseases, disease analysis and dynamic monitoring of drug efficacy in vivo.

Description

technical field [0001] The invention relates to the field of optical imaging, in particular to a high dynamic laser speckle blood flow imaging device and method with selectable regions. Background technique [0002] Laser speckle blood flow imaging technology is widely used in the field of biomedical research, providing a full-field optical blood flow imaging method without scanning. This imaging system uses a laser to irradiate the sample to generate speckle signals, and then uses a high-sensitivity coupling device (CCD) to receive the speckle signals emitted by the object to obtain a full-field two-dimensional blood flow distribution image. The speckle signal can be divided into dynamic speckle and static speckle. The speckle signal in which the intensity of the speckle signal in the region where the scattering particle is located is caused by the movement of the scattering particle to fluctuate randomly is called dynamic speckle. Otherwise, the intensity of the speckle si...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/026
CPCA61B5/0261
Inventor 王茗祎罗佳雄韩定安曾亚光
Owner FOSHAN UNIVERSITY
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