The invention discloses a multi-mode co-location measuring
system and a multi-mode co-location measuring method for
birefringence and
blood flow detection of biological tissues, and the multi-mode co-location measuring
system for
birefringence and
blood flow detection of the biological tissues comprises a multi-mode co-location measuring
system and a multi-mode co-location measuring method, two technologies of measuring tissue
birefringence characteristics through speckle
interferometry and measuring micro
blood flow distribution through
speckle contrast imaging are fused on a single optical platform, and by controlling opening and closing of a reference light path, the system can realize high-sensitivity phase / birefringence
interferometry and closing of the reference light when the reference light is opened, so that high-sensitivity phase / birefringence
interferometry is realized. And the
dynamic speckle statistics is used for measuring blood flow distribution for switching. According to the two
modes, a homologous illumination light path and a shared core detection light path are used, it is ensured that after the
modes are switched, the same area of a biological sample is imaged,
image registration errors which are difficult to overcome in traditional subsystem imaging are eliminated,
fine structure information and
microcirculation hemodynamic information of tissue are synchronously obtained, and the imaging accuracy is improved. And a co-location and real-time imaging means is provided for researching space-
time correlation between tissue
microstructure change and local hemodynamic change.